Information on EC 1.2.1.107 - glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

for references in articles please use BRENDA:EC1.2.1.107
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EC Tree
IUBMB Comments
The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arseno-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
acylglyceraldehyde-3-phosphate dehydrogenase, AsV reductase, D-glyceraldehyde-3-phosphate dehydrogenase, FA-GPDH, G3P dehydrogenase, G3PD, G3PDH, GAPDH, glyceraldehyde-3-P dehydrogenase, GPD, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+
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PATHWAY SOURCE
PATHWAYS
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