Reference on EC 1.2.1.105 - 2-oxoglutarate dehydrogenase system
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yeaman, S.J.
The mammalian 2-oxoacid dehydrogenases: a complex family
Trends Biochem. Sci.
11
293-296
1986
Sus scrofa
-
Reed, L.J.; Cox, D.J.
Multienzyme complexes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
1
213-240
1970
Bos taurus, Escherichia coli, Sus scrofa
-
Rutter, G.A.; Denton, R.M.
The binding of Ca2+ ions to pig heart NAD+-isocitrate dehydrogenase and the 2-oxoglutarate dehydrogenase complex
Biochem. J.
263
453-462
1989
Sus scrofa
Heckert, L.L.; Butler, M.H.; Reimers, J.M.; Albe, K.R.; Wright, B.E.
Purification and characterization of the 2-oxoglutarate dehydrogenase complex from Dictyostelium discoideum
J. Gen. Microbiol.
135
155-161
1989
Dictyostelium discoideum
Bessam, H.; Mareck, A.M.; Foucher, B.
Neurospora crassa alpha-ketoglutarate dehydrogenase complex: description, resolution of components and catalytic properties
Biochim. Biophys. Acta
990
66-72
1989
Neurospora crassa
Reed, L.J.; Mukherjee, B.B.
alpha-Ketoglutarate dehydrogenase complex from Escherichia coli
Methods Enzymol.
13
55-61
1969
Escherichia coli
-
Sanadi, D.R.
alpha-Ketoglutarate dehydrogenase from pig heart
Methods Enzymol.
13
52-55
1969
Sus scrofa
-
Murphy, A.N.; Kelleher, J.K.; Fiskum, G.
Calcium sensitive isocitrate and 2-oxoglutarate dehydrogenase activities in rat liver and AS-30D hepatoma mitochondria
Biochem. Biophys. Res. Commun.
157
1218-1255
1988
Rattus norvegicus
Iwata, H.; Tonomura, H.; Matsuda, T.
Transketolase and 2-oxoglutarate dehydrogenase activities in the brain and liver of the developing rat
Experientia
44
780-781
1988
Rattus norvegicus
Cho, H.Y.; Widholm, J.M.; Slife, F.W.
Haloxyfop inhibition of the pyruvate and the alpha-ketoglutarate dehydrogenase complexes of corn (Zea mays L.) and soybean (Glycine max [L.] Merr.)
Plant Physiol.
87
334-340
1988
Glycine max, Zea mays
Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latip, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate
Biochem. J.
229
127-133
1985
Sus scrofa
Meixner-Monori, B.; Kubicek, C.P.; Habison, A.; Kubicek-Pranz, E.M.; Roehr, M.
Presence and regulation of the alpha-ketoglutarate dehydrogenase multienzyme complex in the filamentous fungus Aspergillus niger
J. Bacteriol.
161
265-271
1985
Aspergillus niger
Lawlis, V.B.; Roche, T.E.
Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibition
Biochemistry
20
2319-2324
1981
Bos taurus
-
Shiio, I.; Ujigawa-Takeda, U.
Presence and regulation of alphe-ketoglutarate dehydrogenase complex in a glutamate-producing bacterium Brevibacterium flavum
Agric. Biol. Chem.
44
1897-1904
1980
[Brevibacterium] flavum
-
De Kok, A.; Kornfeld, S.; Benziman, M.; Milner, Y.
Subunit composition and partial reactions of the 2-oxoglutarate dehydrogenase complex of Acetobacter xylinum
Eur. J. Biochem.
106
49-58
1980
Komagataeibacter xylinus
Gupta, S.C.; Dekker, E.E.
Evidence for the identity and some comparative properties of alpha-ketoglutarate and 2-keto-4-hydroxyglutarate dehydrogenase activity
J. Biol. Chem.
255
1107-1112
1980
Escherichia coli, Sus scrofa
Gupta, S.C.; Dekker, E.E.
Oxidation of 2-keto-4-hydroxyglutarate by pig heart and Escherichia coli alpha-ketoglutarate dehydrogenase complex
Arch. Biochem. Biophys.
192
324-326
1979
Escherichia coli, Sus scrofa
Waskiewicz, D.E.; Hammes, G.G.
Elementary steps in the reaction mechanism of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli: kinetics of succinylation and desuccinylation
Biochemistry
23
3136-3143
1984
Escherichia coli
McMinn, C.L.; Ottaway, J.H.
Studies on the mechanism and kinetics of the 2-oxoglutarate dehydrogenase system from pig heart
Biochem. J.
161
569-581
1977
Komagataeibacter xylinus, Sus scrofa
Kornfeld, S.; Benziman, M.; Milner, Y.
alpha-Ketoglutarate dehydrogenase complex of Acetobacter xylinum. Purification and regulatory properties
J. Biol. Chem.
252
2940-2947
1977
Komagataeibacter xylinus
Parker, M.G.; Weitzman, P.D.J.
The purification and regulatory properties of alpha-oxoglutarate dehydrogenase from Acinetobacter lwoffi
Biochem. J.
135
215-223
1973
Acinetobacter lwoffii
Hirashima, M.; Hayakawa, T.; Koike, M.
Mammalian alpha-keto acid dehydrogenase complexes. II. An improved procedure for the preparation of 2-oxoglutarate dehydrogenase complex from pig heart muscle
J. Biol. Chem.
242
902-907
1967
Sus scrofa
Kanzaki, T.; Hayakawa, T.; Hamada, M.; Fukuyoshi, Y.; Koike, M.
Mammalian alpha-keto acid dehydrogenase complexes. IV. Substrate specificities and kinetic properties of the pig heart pyruvate and 2-oxoglutarate dehydrogenase complexes
J. Biol. Chem.
244
1183-1187
1969
Sus scrofa
Tanaka, N.; Koike, K.; Hamada, M.; Otsuka, K.; Suematsu, T.; Koike, M.
Mammalian alpha-keto acid dehydrogenase complexes. VII. Resolution and reconstitution of the pig heart 2-oxoglutarate dehydrogenase complex
J. Biol. Chem.
247
4043-4049
1972
Sus scrofa
Pettit, F.H.; Hamilton, L.; Munk, P.; Namihira, G.; Eley, M.H.; Willms, C.R.; Reed, L.J.
alpha-Keto acid dehydrogenase complexes. XIX. Subunit structure of the Escherichia coli alpha-ketoglutarate dehydrogenase complex
J. Biol. Chem.
248
5282-5290
1973
Escherichia coli
Hirabayashi, T.; Harada, T.
Inhibition of the alpha-ketoglutarate dehydrogenase complex from baker's yeast by acetaldehyde and glyoxylate
Agric. Biol. Chem.
36
1249-1251
1972
Saccharomyces cerevisiae
-
Weitzman, P.D.J.
Regulation of alpha-ketoglutarate dehydrogenase activity in Acinetobacter
FEBS Lett.
22
323-326
1972
Acinetobacter sp., Acinetobacter sp. 4B
Hirabayashi, T.; Harada, T.
Isolation and properties of alpha-ketoglutarate dehydrogenase complex from bakers yeast (Saccharomyces cerevisiae)
Biochem. Biophys. Res. Commun.
45
1369-1375
1971
Saccharomyces cerevisiae
Brown, A.M.; Kristal, B.S.; Effron, M.S.; Shestopalov, A.I.; Ullucci, P.A.; Sheu, K.F.; Blass, J.P.; Cooper, A.J.
Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex
J. Biol. Chem.
275
13441-13447
2000
Sus scrofa
Shen, X.M.; Li, H.; Dryhurst, G.
Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease
J. Neural Transm.
107
959-978
2000
Rattus norvegicus
Xin, W.; Shen, X.M.; Li, H.; Dryhurst, G.
Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes: possible implications for neurodegenerative brain disorders
Chem. Res. Toxicol.
13
749-760
2000
Rattus norvegicus
McNaught, K.S.; Altomare, C.; Cellamare, S.; Carotti, A.; Thull, U.; Carrupt, P.A.; Testa, B.; Jenner, P.; Marsden, C.D.
Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
NeuroReport
6
1105-1108
1995
Rattus norvegicus
Faff-Michalak, L.; Albrecht, J.
The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: Comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy
Neurochem. Res.
18
119-123
1993
Rattus norvegicus
Gibson, G.E.; Park, L.C.H.; Sheu, K.F.R.; Blass, J.P.; Calingasan, N.Y.
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration
Neurochem. Int.
36
97-112
2000
Saccharomyces cerevisiae, Homo sapiens
Aevarsson, A.; Chuang, J.L.; Wynn, R.M.; Turley, S.; Chuang, D.T.; Hol, W.G.J.
Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease
Structure
8
277-291
2000
Solanum tuberosum
Sheu, K.F.R.; Blass, J.P.
The alpha-ketoglutarate dehydrogenase complex
Ann. N. Y. Acad. Sci.
893
61-78
1999
Saccharomyces cerevisiae, Homo sapiens
Biryukov, A.I.; Bunik, V.I.; Zhukov, Y.N.; Khurs, E.N.; Khomutov, R.M.
Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle
FEBS Lett.
382
167-170
1996
Escherichia coli, Pigeon
Bunik, V.; Westphal, A.H.; de Kok, A.
Kinetic properties of the 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii evidence for the formation of a precatalytic complex with 2-oxoglutarate
Eur. J. Biochem.
267
3583-3591
2000
Azotobacter vinelandii
Perham, R.N.; Jones, D.D.; Chauhan, H.J.; Howard, M.J.
Substrate channeling in 2-oxo acid dehydrogenase multienzyme complexes
Biochem. Soc. Trans.
30
47-51
2002
Azotobacter vinelandii, Geobacillus stearothermophilus, Escherichia coli, Pseudomonas putida
Huang, H.M.; Zhang, H.; Xu, H.; Gibson, G.E.
Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation
Biochim. Biophys. Acta
1637
119-126
2003
Homo sapiens
Jiang, X.R.; Dryhurst, G.
Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione
Chem. Res. Toxicol.
15
1242-1247
2002
Rattus norvegicus
Kumar, M.J.; Nicholls, D.G.; Andersen, J.K.
Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease
J. Biol. Chem.
278
46432-46439
2003
Homo sapiens
Habelhah, H.; Laine, A.; Erdjument-Bromage, H.; Tempst, P.; Gershwin, M.E.; Bowtell, D.D.; Ronai, Z.
Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah
J. Biol. Chem.
279
53782-53788
2004
Homo sapiens
Strumilo, S.; Czygier, M.; Kondracikowska, J.; Dobrzyn, P.; Czerniecki, J.
Kinetic and spectral investigation of allosteric interaction of coenzymes with 2-oxo acid dehydrogenase complexes
J. Mol. Struct.
614
221-226
2002
Bos taurus
-
Jeitner, T.M.; Xu, H.; Gibson, G.E.
Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine
J. Neurochem.
92
302-310
2005
Homo sapiens, Mus musculus, Sus scrofa
Bunik, V.I.; Denton, T.T.; Xu, H.; Thompson, C.M.; Cooper, A.J.; Gibson, G.E.
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells
Biochemistry
44
10552-10561
2005
Bos taurus, Homo sapiens
Zhang, L.; Cooper, A.J.; Krasnikov, B.F.; Xu, H.; Bubber, P.; Pinto, J.T.; Gibson, G.E.; Hanigan, M.H.
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells
Biochemistry
45
8959-8971
2006
Sus scrofa
Strumilo, S.
Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors
Biochemistry
70
726-729
2005
Bison bison, Bos taurus, Columba livia, Escherichia coli, Homo sapiens, Rattus norvegicus, Solanum tuberosum, Sus scrofa
Bunik, V.I.; Raddatz, G.; Wanders, R.J.; Reiser, G.
Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid
FEBS Lett.
580
3551-3557
2006
Rattus norvegicus
Waagepetersen, H.S.; Hansen, G.H.; Fenger, K.; Lindsay, J.G.; Gibson, G.; Schousboe, A.
Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase
Glia
53
225-231
2006
Mus musculus
Santos, S.S.; Gibson, G.E.; Cooper, A.J.; Denton, T.T.; Thompson, C.M.; Bunik, V.I.; Alves, P.M.; Sonnewald, U.
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons
J. Neurosci. Res.
83
450-458
2006
Mus musculus
Gibson, G.E.; Blass, J.P.; Beal, M.F.; Bunik, V.
The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration
Mol. Neurobiol.
31
43-63
2005
Bos taurus, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa
Tretter, L.; Adam-Vizi, V.
alpha-Ketoglutarate dehydrogenase: a target and generator of oxidative stress
Philos. Trans. R. Soc. Lond. B Biol. Sci.
360
2335-2345
2005
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Applegate, M.A.; Humphries, K.M.; Szweda, L.I.
Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid
Biochemistry
47
473-478
2008
Rattus norvegicus
Shi, Q.; Xu, H.; Kleinman, W.A.; Gibson, G.E.
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimers disease
Biochim. Biophys. Acta
1782
229-238
2008
Homo sapiens
Hasegawa, T.; Hashimoto, K.; Kawasaki, H.; Nakamatsu, T.
Changes in enzyme activities at the pyruvate node in glutamate-overproducing Corynebacterium glutamicum
J. Biosci. Bioeng.
105
12-19
2008
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13869
Bunik, V.I.; Degtyarev, D.
Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins
Proteins
71
874-890
2008
Geobacillus stearothermophilus, Homo sapiens (Q96HY7), Homo sapiens (Q9ULD0)
Shi, Q.; Risa, O.; Sonnewald, U.; Gibson, G.E.
Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis
J. Neurochem.
109 Suppl 1
214-221
2009
Homo sapiens
Pankotai, E.; Lacza, Z.; Muranyi, M.; Szabo, C.
Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase
Mitochondrion
9
159-164
2009
Rattus norvegicus
Zuendorf, G.; Kahlert, S.; Bunik, V.I.; Reiser, G.
alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ
Neuroscience
158
610-616
2009
Rattus norvegicus
Araujo, W.L.; Nunes-Nesi, A.; Trenkamp, S.; Bunik, V.I.; Fernie, A.R.
Inhibition of 2-oxoglutarate dehydrogenase in potato tuber suggests the enzyme is limiting for respiration and confirms its importance in nitrogen assimilation,
Plant Physiol.
148
1782-1796
2008
Solanum tuberosum
Sykes, S.E.; Hajduk, S.L.
Dual functions of alpha-ketoglutarate dehydrogenase E2 in the Krebs cycle and mitochondrial DNA inheritance in Trypanosoma brucei
Eukaryot. Cell
12
78-90
2013
Trypanosoma brucei
Gibson, G.E.; Xu, H.; Chen, H.L.; Chen, W.; Denton, T.T.; Zhang, S.
alpha-Ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines
J. Neurochem.
134
86-96
2015
Mus musculus
Araujo, W.L.; Trofimova, L.; Mkrtchyan, G.; Steinhauser, D.; Krall, L.; Graf, A.; Fernie, A.R.; Bunik, V.I.
On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism
Amino Acids
44
683-700
2013
Arabidopsis thaliana, Rattus norvegicus
Millar, A.H.; Hill, S.A.; Leaver, C.J.
Plant mitochondrial 2-oxoglutarate dehydrogenase complex purification and characterization in potato
Biochem. J.
343 Pt 2
327-334
1999
Solanum tuberosum (P81895 and P81896 and P80503)
Armstrong, C.T.; Anderson, J.L.; Denton, R.M.
Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site
Biochem. J.
459
369-381
2014
Sus scrofa, Homo sapiens (Q02218)
Robien, M.A.; Clore, G.M.; Omichinski, J.G.; Perham, R.N.; Appella, E.; Sakaguchi, K.; Gronenborn, A.M.
Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli
Biochemistry
31
3463-3471
1992
Escherichia coli (P0AFG6)
Shim, d.a. .J.; Nemeria, N.S.; Balakrishnan, A.; Patel, H.; Song, J.; Wang, J.; Jordan, F.; Farinas, E.T.
Assignment of function to histidines 260 and 298 by engineering the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase complex; substitutions that lead to acceptance of substrates lacking the 5-carboxyl group
Biochemistry
50
7705-7709
2011
Escherichia coli (P0AFG3)
Nemeria, N.S.; Gerfen, G.; Yang, L.; Zhang, X.; Jordan, F.
Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the L-lysine, L-hydroxylysine and L-tryptophan degradation pathways from studies in vitro
Biochim. Biophys. Acta Bioenerg.
1859
932-939
2018
Homo sapiens (A0A024R713 and A0A024R6C9)
Mareck, A.; Bessam, H.; Delattre, P.; Foucher, B.
Purification of the 2-oxoglutarate dehydrogenase and pyruvate dehydrogenase complexes of Neurospora crassa mitochondria
Biochimie
68
1175-1180
1986
Neurospora crassa
Pawelczyk, T.; Angielski, S.
Effect of ionic strength on the regulatory properties of 2-oxoglutarate dehydrogenase complex
Biochimie
74
171-176
1992
Sus scrofa
Nemeria, N.S.; Gerfen, G.; Guevara, E.; Nareddy, P.R.; Szostak, M.; Jordan, F.
The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate
Free Radic. Biol. Med.
108
644-654
2017
Homo sapiens (A0A024R713 and A0A024R6C9 and Q02218), Homo sapiens (Q02218)
Koike, K.; Tanaka, N.; Hamada, M.; Otsuka, K.; Suematsu, T.; Koike, M.
Resolution and reconstitution of pig heart 2-oxoglutarate dehydrogenase complex
J. Biochem.
69
1143-1147
1971
Sus scrofa
Zhou, J.; Yang, L.; Ozohanics, O.; Zhang, X.; Wang, J.; Ambrus, A.; Arjunan, P.; Brukh, R.; Nemeria, N.S.; Furey, W.; Jordan, F.
A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex
J. Biol. Chem.
293
19213-19227
2018
Homo sapiens (A0A024R713 and A0A024R6C9)
Koike, K.
Human pyruvate and 2-oxoglutarate dehydrogenase complexes Tissue-specific expression
J. Clin. Biochem. Nutr.
30
67-77
2001
Homo sapiens
-
Strumilo, S.; Bielska, M.; Kazaniecki, L.; Tylicki, A.
Kinetic properties of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes from a new source - the heart of wild boar Sus scrofa
J. Evol. Biochem. Physiol.
51
438-440
2015
Sus scrofa
-
Knapp, J.E.; Mitchell, D.T.; Yazdi, M.A.; Ernst, S.R.; Reed, L.J.; Hackert, M.L.
Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex
J. Mol. Biol.
280
655-668
1998
Escherichia coli (P0AFG6)
Kinugawa, H.; Kondo, N.; Komine-Abe, A.; Tomita, T.; Nishiyama, M.; Kosono, S.
In vitro reconstitution and characterization of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase hybrid complex from Corynebacterium glutamicum
MicrobiologyOpen
9
e1113
2020
Corynebacterium glutamicum (Q8NRC3 and Q8NNJ2 and Q8NTE1), Corynebacterium glutamicum DSM 20300 (Q8NRC3 and Q8NNJ2 and Q8NTE1)
Bailey, P.S.J.; Ortmann, B.M.; Martinelli, A.W.; Houghton, J.W.; Costa, A.S.H.; Burr, S.P.; Antrobus, R.; Frezza, C.; Nathan, J.A.
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
Nat. Commun.
11
4046
2020
Homo sapiens (Q02218 and P36957 and P09622)
Condori-Apfata, J.A.; Batista-Silva, W.; Medeiros, D.B.; Vargas, J.R.; Valente, L.M.L.; Heyneke, E.; Perez-Diaz, J.L.; Fernie, A.R.; Araujo, W.L.; Nunes-Nesi, A.
The Arabidopsis E1 subunit of the 2-oxoglutarate dehydrogenase complex modulates plant growth and seed production
Plant Mol. Biol.
101
183-202
2019
Arabidopsis thaliana (F4IWV2), Arabidopsis thaliana (Q9FLH2)
Murphy, G.; Jensen, G.
Electron cryotomography of the E. coli pyruvate and 2-oxoglutarate dehydrogenase complexes
Structure
13
1765-1773
2005
Escherichia coli
Tsepkova, P.M.; Artiukhov, A.V.; Boyko, A.I.; Aleshin, V.A.; Mkrtchyan, G.V.; Zvyagintseva, M.A.; Ryabov, S.I.; Ksenofontov, A.L.; Baratova, L.A.; Graf, A.V.; Bunik, V.I.
Thiamine induces long-term changes in amino acid profiles and activities of 2-oxoglutarate and 2-oxoadipate dehydrogenases in rat brain
Biochemistry
82
723-736
2017
Rattus norvegicus
Green, S.R.; Storey, K.B.
Regulation of the alpha-ketoglutarate dehydrogenasecomplex during hibernation in a small mammal, the Richardsons ground squirrel (Urocitellus richardsonii)
Biochim. Biophys. Acta Proteins Proteom.
1868
140448
2020
Urocitellus richardsonii
Lu, X.; Yang, P.; Zhao, X.; Jiang, M.; Hu, S.; Ouyang, Y.; Zeng, L.; Wu, J.
OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer
Exp. Cell Res.
382
111483
2019
Homo sapiens
Nemeria, N.S.; Gerfen, G.; Nareddy, P.R.; Yang, L.; Zhang, X.; Szostak, M.; Jordan, F.
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
Free Radic. Biol. Med.
115
136-145
2018
Homo sapiens (Q96HY7 and Q02218)
Baldi, N.; Dykstra, J.C.; Luttik, M.A.H.; Pabst, M.; Wu, L.; Benjamin, K.R.; Vente, A.; Pronk, J.T.; Mans, R.
Functional expression of a bacterial alpha-ketoglutarate dehydrogenase in the cytosol of Saccharomyces cerevisiae
Metab. Eng.
56
190-197
2019
Escherichia coli (P0AFG3 and P0AFG6 and P0A9P0)
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