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Information on EC 1.17.99.4 - uracil/thymine dehydrogenase

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IUBMB Comments
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (beta-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 .
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The enzyme appears in viruses and cellular organisms
Synonyms
dehydrogenase, uracil, EC 1.1.99.19, EC 1.2.99.1, uracil dehydrogenase, uracil oxidase, uracil-thymidine oxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor
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uracil + H2O + acceptor = barbiturate + reduced acceptor
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PATHWAY SOURCE
PATHWAYS
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