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Information on EC - leucoanthocyanidin reductase

for references in articles please use BRENDA:EC1.17.1.3
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EC Tree
     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.1 With NAD+ or NADP+ as acceptor
       leucoanthocyanidin reductase
IUBMB Comments
The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.
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Word Map
The enzyme appears in viruses and cellular organisms
anthocyanidin reductase, ptrlar3, cslar, palar3, mtlar, ptrlar1, leucocyanidin reductase, mdlar1, leucoanthocyanidin 4-reductase, vv lar1, more
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
show the reaction diagram
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