noncompetitive inhibition, binding structure analysis, strongest interaction between terbinafine and enzyme stems from hydrogen bonding between hydrogen-bond donors, hydroxyl group of Tyr90 and amine nitrogen atom of terbinafine, mechanism of squalene epoxidase inhibition, overview. Inhibitor identification via docking studies followed by molecular dynamics simulations, based on PDB IDS 2QA1 and 1PBE templates, and quantum interaction energy calculations, overview
PgSQE1 mRNA abundantly accumulates in all organs. PgSQE1 mRNA accumulates preferentially in vascular bundle tissue and resin ducts of petioles; PgSQE2 is only weakly expressed and preferentially in petioles and flower buds. PgSQE2 mRNAs accumulates preferentially in vascular bundle tissue and resin ducts of petioles
PgSQE1 mRNA abundantly accumulates in all organs. PgSQE1 mRNA accumulates preferentially in vascular bundle tissue and resin ducts of petioles; PgSQE2 is only weakly expressed and preferentially in petioles and flower buds. PgSQE2 mRNAs accumulates preferentially in vascular bundle tissue and resin ducts of petioles
squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner; squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner, and that PgSQE1 regulates ginsenoside biosynthesis, but not that of phytosterols in Panax ginseng
RNA interference of PgSQE1 in transgenic Panax ginseng plants completely suppresses PgSQE1 transcription. Concomitantly, the interference of PgSQE1 results in reduction of ginsenoside production
RNA interference of PgSQE1 in transgenic Panax ginseng plants completely suppresses PgSQE1 transcription. Concomitantly, the interference of PgSQE1 results in reduction of ginsenoside production
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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
gene PgSQE1, DNA and amino acid sequence determination and analysis, phylogenetic analysis; gene PgSQE2, DNA and amino acid sequence determination and analysis, phylogenetic analysis
squalene treatment coordinately upregulates the expression of PgSQE1, and methyl jasmonate treatment enhances the accumulation of PgSQE1 mRNA in roots. Silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation; squalene treatment coordinately upregulates the expression of PgSQE2. Silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation
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1.14.99.7 squalene monooxygenase
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