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Information on EC 1.14.99.46 - pyrimidine oxygenase

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IUBMB Comments
The enzyme participates in the Rut pyrimidine catabolic pathway. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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(Z)-3-ureidoacrylate
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(Z)-2-methylureidoacrylate
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Synonyms
RutA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+
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(1c), spontaneous; (2b), spontaneous
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thymine + FMNH2 + O2 + NADH = (Z)-2-methylureidoacrylate + H2O + FMN + NAD+ + H+
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(2) overall reaction
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thymine + FMNH2 + O2 = (Z)-2-methylureidoacrylate + FMN-N5-oxide
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(2a)
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uracil + FMNH2 + O2 + NADH = (Z)-3-ureidoacrylate + H2O + FMN + NAD+ + H+
show the reaction diagram
(1) overall reaction
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uracil + FMNH2 + O2 = (Z)-3-ureidoacrylate + FMN-N5-oxide
show the reaction diagram
(1a)
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PATHWAY SOURCE
PATHWAYS
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