Reference on EC 1.14.99.38 - cholesterol 25-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Russell, D.W.
Oxysterol biosynthetic enzymes
Biochim. Biophys. Acta
1529
126-135
2000
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
Lukyanenko, Y.O.; Chen, J.J.; Hutson, J.C.
Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells
Biol. Reprod.
64
790-796
2001
Rattus norvegicus
Chen, J.J.; Lukyanenko, Y.; Hutson, J.C.
25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro
Biol. Reprod.
66
1336-1341
2002
Rattus norvegicus
Lukyanenko, Y.; Chen, J.J.; Hutson, J.C.
Testosterone regulates 25-hydroxycholesterol production in testicular macrophages
Biol. Reprod.
67
1435-1438
2002
Rattus norvegicus
Lund, E.G.; Kerr, T.A.; Sakai, J.; Li, W.P.; Russell, D.W.
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
J. Biol. Chem.
273
34316-34327
1998
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
Shibata, N.; Kawarai, T.; Lee, J.H.; Lee, H.S.; Shibata, E.; Sato, C.; Liang, Y.; Duara, R.; Mayeux, R.P.; St George-Hyslop, P.H.; Rogaeva, E.
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
Neurosci. Lett.
391
142-146
2006
Homo sapiens
Papassotiropoulos, A.; Lambert, J.C.; Wavrant-De Vrieze, F.; Wollmer, M.A.; von der Kammer, H.; Streffer, J.R.; Maddalena, A.; Huynh, K.D.; Wolleb, S.; Lutjohann, D.; Schneider, B.; Thal, D.R.; Grimaldi, L.M.; Tsolaki, M.; Kapaki, E.; Ravid, R.; Konietzko, U.; Hegi, T.; Pasch, T.; Jung, H.; Braak, H.
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimers disease
Neurodegener. Dis.
2
233-241
2005
Homo sapiens
Diczfalusy, U.; Olofsson, K.; Carlsson, A.; Gong, M.; Golenbock, D.; Rooyackers, O.; Flring, U.; Bjrkbacka, H.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
J. Lipid Res.
50
2258-2264
2009
Homo sapiens, Mus musculus
Bauman, D.R.; Bitmansour, A.D.; McDonald, J.G.; Thompson, B.M.; Liang, G.; Russell, D.W.
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
Proc. Natl. Acad. Sci. USA
106
16764-16769
2009
Mus musculus
Park, K.; Scott, A.L.
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
J. Leukoc. Biol.
88
1081-1087
2010
Mus musculus, Mus musculus BALB/cJ
Holmes, R.S.; Vandeberg, J.L.; Cox, L.A.
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)
3 Biotech
1
99-109
2011
Canis lupus familiaris, Gallus gallus, Xenopus tropicalis, Equus caballus (F6T000), Macaca mulatta (F7EC50), Homo sapiens (O95992), Homo sapiens, Bos taurus (Q0P599), Rattus norvegicus (Q4QQV7), Mus musculus (Q9Z0F5)
Diczfalusy, U.
On the formation and possible biological role of 25-hydroxycholesterol
Biochimie
95
455-460
2013
Rattus norvegicus, Sus scrofa, Homo sapiens (Q02318), Mus musculus (Q64459)
Liu, S.Y.; Aliyari, R.; Chikere, K.; Li, G.; Marsden, M.D.; Smith, J.K.; Pernet, O.; Guo, H.; Nusbaum, R.; Zack, J.A.; Freiberg, A.N.; Su, L.; Lee, B.; Cheng, G.
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
Immunity
38
92-105
2013
Mus musculus (Q9Z0F5)
Honda, A.; Miyazaki, T.; Ikegami, T.; Iwamoto, J.; Maeda, T.; Hirayama, T.; Saito, Y.; Teramoto, T.; Matsuzaki, Y.
Cholesterol 25-hydroxylation activity of CYP3A
J. Lipid Res.
52
1509-1516
2011
Homo sapiens (P05177), Homo sapiens (P08684), Homo sapiens (P10635), Homo sapiens (P11712), Mus musculus (Q9Z0F5)
Li, Z.; Martin, M.; Zhang, J.; Huang, H.Y.; Bai, L.; Zhang, J.; Kang, J.; He, M.; Li, J.; Maurya, M.R.; Gupta, S.; Zhou, G.; Sangwung, P.; Xu, Y.J.; Lei, T.; Huang, H.D.; Jain, M.; Jain, M.K.; Subramaniam, S.; Shyy, J.Y.
Krueppel-like factor 4 regulation of cholesterol-25-hydroxylase and liver X receptor mitigates atherosclerosis susceptibility
Circulation
136
1315-1330
2017
Mus musculus (Q9Z0F5)
Anggakusuma, G.; Romero-Brey, I.; Berger, C.; Colpitts, C.C.; Boldanova, T.; Engelmann, M.; Todt, D.; Perin, P.M.; Behrendt, P.; Vondran, F.W.; Xu, S.; Goffinet, C.; Schang, L.M.; Heim, M.H.; Bartenschlager, R.; Pietschmann, T.; Steinmann, E.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Hepatology
62
702-714
2015
Homo sapiens (Q95992), Homo sapiens
Noebauer, B.; Jais, A.; Todoric, J.; Gossens, K.; Sutterluety-Fall, H.; Einwallner, E.
Hepatic cholesterol-25-hydroxylase overexpression improves systemic insulin sensitivity in mice
J. Diabetes Res.
2017
4108768
2017
Mus musculus
Wang, J.; Zeng, L.; Zhang, L.; Guo, Z.Z.; Lu, S.F.; Ming, S.L.; Li, G.L.; Wan, B.; Tian, K.G.; Yang, G.Y.; Chu, B.B.
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication
J. Gen. Virol.
98
1467-1476
2017
Sus scrofa
Mukherjee, P.; Hough, G.; Chattopadhyay, A.; Navab, M.; Fogelman, H.R.; Meriwether, D.; Williams, K.; Bensinger, S.; Moller, T.; Faull, K.F.; Lusis, A.J.; Iruela-Arispe, M.L.; Bostrom, K.I.; Tontonoz, P.; Reddy, S.T.; Fogelman, A.M.
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-beta and cholesterol 25-hydroxylase in jejunum
J. Lipid Res.
58
1636-1647
2017
Mus musculus
Xiang, Y.; Tang, J.J.; Tao, W.; Cao, X.; Song, B.L.; Zhong, J.
Identification of cholesterol 25-hydroxylase as a novel host restriction factor and a part of the primary innate immune responses against hepatitis C virus infection
J. Virol.
89
6805-6816
2015
Homo sapiens
Ke, W.; Fang, L.; Jing, H.; Tao, R.; Wang, T.; Li, Y.; Long, S.; Wang, D.; Xiao, S.
Cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication through enzyme activity-dependent and -independent mechanisms
J. Virol.
91
e00827-17
2017
Sus scrofa
Chen, Y.; Wang, S.; Yi, Z.; Tian, H.; Aliyari, R.; Li, Y.; Chen, G.; Liu, P.; Zhong, J.; Chen, X.; Du, P.; Su, L.; Qin, F.X.; Deng, H.; Cheng, G.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
Sci. Rep.
4
7242
2014
Homo sapiens (Q95992)
Tsujioka, T.; Yokoi, A.; Itano, Y.; Takahashi, K.; Ouchida, M.; Okamoto, S.; Kondo, T.; Suemori, S.; Tohyama, Y.; Tohyama, K.
Five-aza-2-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
Sci. Rep.
5
16709
2015
Homo sapiens (Q95992)
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