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Information on EC 1.14.99.37 - taxadiene 5alpha-hydroxylase

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IUBMB Comments
This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.
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The expected taxonomic range for this enzyme is: Taxus
Synonyms
cyp725a4, taxa-4(5),11(12)-diene 5alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taxa-4,11-diene + reduced acceptor + O2 = taxa-4(20),11-dien-5alpha-ol + acceptor + H2O
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