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Information on EC 1.14.99.12 - androst-4-ene-3,17-dione monooxygenase

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IUBMB Comments
Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC 1.14.13.54, ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.4, progesterone monooxygenase.
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The enzyme appears in viruses and cellular organisms
Synonyms
androstenedione monooxygenase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
androstenedione + reduced acceptor + O2 = testololactone + acceptor + H2O
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FNR is able to transfer electrons between one-electron carriers, ferredoxin or flavodoxin, and two-electron carriers, NADP+ and NADPH, involving its redox cofactor FAD, involvement of Glu312 in the FNR catalytic mechanism not only as a proton donor but also as a key residue for stabilizing and destabilizing reaction intermediates, reaction mechanism and catalytic cycle, overview
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PATHWAY SOURCE
PATHWAYS
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