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Information on EC 1.14.20.8 - (-)-deoxypodophyllotoxin synthase

for references in articles please use BRENDA:EC1.14.20.8
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IUBMB Comments
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
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  • 1.14.20.8
  • lake
  • porphyria
  • erythropoietic
  • floating
  • aymaras
  • reed
  • amerindians
  • uroporphyrinogen
  • altiplano
  • andean
  • front
  • mtdna
  • amazon
  • peruvian
  • shore
  • synthesis
The expected taxonomic range for this enzyme is: Sinopodophyllum hexandrum
Synonyms
2-ODD, deoxypodophyllotoxin synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O
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