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Information on EC 1.14.19.72 - (-)-pluviatolide synthase

for references in articles please use BRENDA:EC1.14.19.72
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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
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The enzyme appears in viruses and cellular organisms
Synonyms
CYP719A23, CYP719A24, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-matairesinol + [reduced NADPH-hemoprotein reductase] + O2 = (-)-pluviatolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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