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Information on EC 1.14.19.67 - salutaridine synthase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
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The enzyme appears in viruses and cellular organisms
Synonyms
(R)-reticuline dehydrogenase, (R)-reticuline oxidase (C-C phenol-coupling), CYP719B1, dehydrogenase, (R)-reticuline, EC 1.1.3.35, PsSAS, SalSyn, salutaridine synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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