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Information on EC 1.14.19.54 - 1,2-dehydroreticuline synthase

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IUBMB Comments
A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.
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The expected taxonomic range for this enzyme is: Papaver
Synonyms
CYP82Y2, DRS, STORR, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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