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Information on EC 1.14.19.4 - acyl-lipid (11-3)-desaturase

for references in articles please use BRENDA:EC1.14.19.4
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IUBMB Comments
The enzyme, characterized from the protist Euglena gracilis and the microalga Rebecca salina , introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing Delta11 desaturation. The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid. It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate.
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Word Map
  • 1.14.19.4
  • desaturases
  • polyunsaturated
  • desaturation
  • sphingolipids
  • delta6
  • arachidonic
  • front-end
  • euglena
  • sphingoid
  • eicosatrienoic
  • isochrysis
  • ozonolysis
  • tetraene
  • borago
  • dinitrophenyl
  • delta6-fatty
  • galbana
The enzyme appears in viruses and cellular organisms
Synonyms
delta8 desaturase, atsld1, delta8-desaturase, slsld, atsld2, boofd8, delta8-sphingolipid desaturase, delta8 sphingolipid desaturase, delta8 sphingobase desaturase, tpdesb, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an (11Z,14Z)-icosa-11,14-dienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(1)
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an (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(2)
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