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Information on EC - acyl-lipid omega-3 desaturase (cytochrome b5)

for references in articles please use BRENDA:EC1.14.19.25
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IUBMB Comments
This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into alpha-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on gamma-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively . cf. EC, acyl-lipid omega-3 desaturase (ferredoxin).
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The enzyme appears in viruses and cellular organisms
omega-3 fatty acid desaturase, fad3b, fatty acid desaturase 3, fad3c, sdd17, lefad3, msdd17, omega-3 fad, omega-3 fa desaturase, er-type desaturase, more
a linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an alpha-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
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