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Information on EC 1.14.19.22 - acyl-lipid omega-6 desaturase (cytochrome b5)

for references in articles please use BRENDA:EC1.14.19.22
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IUBMB Comments
This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid omega-6 desaturase (ferredoxin).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fad2-1a, fad2-1b, delta12 desaturase, fad2-3, fad2a, omega-6 desaturase, microsomal oleate desaturase, fad2-4, oleoyl-pc desaturase, oleoyl phosphatidylcholine desaturase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
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; also desaturates phosphatidylcholines containing the oleoyl group on O-2 of the glycerol residue
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