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Information on EC 1.14.18.7 - dihydroceramide fatty acyl 2-hydroxylase

for references in articles please use BRENDA:EC1.14.18.7
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IUBMB Comments
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxydihydroceramide + 2 ferricytochrome b5 + H2O
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PATHWAY SOURCE
PATHWAYS
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