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Information on EC 1.14.18.5 - sphingolipid C4-monooxygenase

for references in articles please use BRENDA:EC1.14.18.5
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IUBMB Comments
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase .
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
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