Reference on EC 1.14.16.4 - tryptophan 5-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kaufman, S.
Aromatic amino acid hydroxylases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
18
217-282
1987
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Rattus norvegicus
-
Koizumi, S.; Matsushima, Y.; Nagatsu, T.; Linuma, H.; Takeuchi, T.; Umezawa, H.
3,4-Dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases
Biochim. Biophys. Acta
789
111-118
1984
Rattus norvegicus
Fujisawa, H.; Nakata, H.
Tryptophan 5-monooxygenase from rat brain stem
Methods Enzymol.
142
83-87
1987
Rattus norvegicus
Hasegawa, H.; Ichiyama, A.
Tryptophan 5-monooxygenase from mouse mastocytoma: high-performance liquid chromatography assay
Methods Enzymol.
142
88-92
1987
Mus musculus
Fujisawa, H.; Nakata, H.
Tryptophan 5-monooxygenase from mouse mastocytoma clone P815
Methods Enzymol.
142
93-96
1987
Mus musculus
Nakata, H.; Fujisawa, H.
Simple and rapid purification of tryptophan 5-monooxygenase from rabbit brain by affinity chromatography
J. Biochem.
90
567-569
1981
Oryctolagus cuniculus, Rattus norvegicus
Nukiwa, T.; Tohyama, C.; Okita, C.; Kataoka, T.; Ichiyama, A.
Purification and some properties of bovine pineal tryptophan 5-monooxygenase
Biochem. Biophys. Res. Commun.
60
1029-1035
1974
Bos taurus
Nakata, H.; Fujisawa, H.
Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties
Eur. J. Biochem.
124
595-601
1982
Mus musculus
Nakata, H.; Fujisawa, H.
Purification and properties of tryptophan 5-monooxygenase from rat brain-stem
Eur. J. Biochem.
122
41-47
1982
Rattus norvegicus
Cash, C.D.; Vayer, P.; Mandel, P.; Maitre, M.
Tryptophan 5-hydroxylase. Rapid purification from whole rat brain and production of a specific antiserum
Eur. J. Biochem.
149
239-245
1985
Rattus norvegicus
Hosoda, S.; Nakamura, W.; Takatsuki, K.
Properties of tryptophan hydroxylase from human carcinoid tumor
Biochim. Biophys. Acta
482
27-34
1977
Homo sapiens
Friedman, P.A.; Kappelman, A.H.; Kaufman, S.
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain
J. Biol. Chem.
247
4165-4173
1972
Oryctolagus cuniculus
Ichiyama, A.; Nakamura, S.; Nishizuka, Y.; Hayaishi, O.
Enzymic studies on the biosynthesis of serotonin in mammalian brain
J. Biol. Chem.
245
1699-1709
1970
Bos taurus, Cavia porcellus
Joh, T.H.; Shikimi, T.; Pickel, V.M.; Reis, D.J.
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain
Proc. Natl. Acad. Sci. USA
72
3575-3579
1975
Rattus norvegicus
Tong, J.H.; Kaufman, S.
Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain
J. Biol. Chem.
250
4152-4158
1975
Oryctolagus cuniculus
Naoi, M.; Maruyama, W.; Takahashi, T.; Ota, M.; Parvez, H.
Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids
Biochem. Pharmacol.
48
207-211
1994
Mus musculus
Park, D.H.; Stone, D.M.; Kim, K.S.; Joh, T.H.
Characterization of recombinant mouse tryptophan hydroxylase expressed in Escherichia coli
Mol. Cell. Neurosci.
5
87-93
1994
Mus musculus, Rattus norvegicus
Nagai, T.; Hamada, M.; Kai, N.; Tanoue, Y.; Nagayama, F.
Characterization of yellowfin tuna (Thunnus albacares, Scombroidei) tryptophan hydroxylase
Comp. Biochem. Physiol. B
116
161-165
1997
Thunnus albacares
Moran, G.R.; Daubner, S.C.; Fitzpatrick, P.F.
Expression and characterization of the catalytic core of tryptophan hydroxylase
J. Biol. Chem.
273
12259-12266
1998
Oryctolagus cuniculus
Hamdan, F.F.; Ribeiro, P.
Characterization of a stable form of tryptophan hydroxylase from the human parasite Schistosoma mansoni
J. Biol. Chem.
274
21746-21754
1999
Oryctolagus cuniculus, Schistosoma mansoni (O96370), Schistosoma mansoni
Moran, G.R.; Phillips, R.S.; Fitzpatrick, P.F.
Influence of steric bulk and electrostatics on the hHydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates
Biochemistry
38
16283-16289
1999
Oryctolagus cuniculus
Kowlessur, D.; Kaufman, S.
Cloning and expression of recombinant human pineal tryptophan hydroxylase in Escherichia coli: purification and characterization of the cloned enzyme
Biochim. Biophys. Acta
1434
317-330
1999
Homo sapiens
McKinney, J.; Teigen, K.; Froystein, N.A.; Salauen, C.; Knappskog, P.M.; Haavik, J.; Martinez, A.
Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity
Biochemistry
40
15591-15601
2001
Homo sapiens
Martinez, A.; Knappskog, P.M.; Haavik, J.
A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis
Curr. Med. Chem.
8
1077-1091
2001
Homo sapiens
Yohrling, I.G.; Jiang, G.C.; DeJohn, M.M.; Robertson, D.J.; Vrana, K.E.; Cha, J.H.
Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease
J. Neurochem.
82
1416-1423
2002
Mus musculus
Daubner, S.C.; Moran, G.R.; Fitzpatrick, P.F.
Role of tryptophan hydroxylase Phe313 in determining substrate specificity
Biochem. Biophys. Res. Commun.
292
639-641
2002
Homo sapiens
Khan, I.A.; Thomas, P.
Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain
Arch. Toxicol.
78
316-320
2004
Rattus norvegicus
Walther, D.J.; Bader, M.
A unique central tryptophan hydroxylase isoform
Biochem. Pharmacol.
66
1673-1680
2003
Homo sapiens
Wang, L.; Erlandsen, H.; Haavik, J.; Knappskog, P.M.; Stevens, R.C.
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neutrotransmitters serotonin and melatonin
Biochemistry
41
12569-12574
2002
Homo sapiens (P17752), Homo sapiens
Slominski, A.; Pisarchik, A.; Johansson, O.; Jing, C.; Semak, I.; Slugocki, G.; Wortsman, J.
Tryptophan hydroxylase expression in human skin cells
Biochim. Biophys. Acta
1639
80-86
2003
Homo sapiens
Sanchez, R.L.; Reddy, A.P.; Centeno, M.L.; Henderson, J.A.; Bethea, C.L.
A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques
Brain Res. Mol. Brain Res.
135
194-203
2005
Macaca mulatta
McKinney, J.; Knappskog, P.M.; Haavik, J.
Different properties of the central and peripheral forms of human tryptophan hydroxylase
J. Neurochem.
92
311-320
2005
Homo sapiens
Herrera, R.; Manjarrez, G.; Hernandez, J.
Inhibition and kinetic changes of brain tryptophan-5-hydroxylase during insulin-dependent diabetes mellitus in the rat
Nutr. Neurosci.
8
57-62
2005
Rattus norvegicus
McKinney, J.; Knappskog, P.M.; Pereira, J.; Ekern, T.; Toska, K.; Kuitert, B.B.; Levine, D.; Gronenborn, A.M.; Martinez, A.; Haavik, J.
Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris
Protein Expr. Purif.
33
185-194
2004
Homo sapiens
Walther, D.J.; Peter, J.U.; Bashammakh, S.; Hortnagl, H.; Voits, M.; Fink, H.; Bader, M.
Synthesis of serotonin by a second tryptophan hydroxylase isoform
Science
299
76
2003
Mus musculus (Q8CGV2)
Zhang, X.; Beaulieu, J.M.; Sotnikova, T.D.; Gainetdinov, R.R.; Caron, M.G.
Tryptophan hydroxylase-2 controls brain serotonin synthesis
Science
305
217
2004
Mus musculus (Q8CGV2), Mus musculus
Hasegawa, H.; Ichiyama, A.
Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron
Biochem. Biophys. Res. Commun.
338
277-284
2005
Homo sapiens, Mus musculus
Zhang, X.; Beaulieu, J.M.; Gainetdinov, R.R.; Caron, M.G.
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2
Cell. Mol. Life Sci.
63
6-11
2006
Danio rerio, Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Winge, I.; McKinney, J.A.; Knappskog, P.M.; Haavik, J.
Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2
J. Neurochem.
100
1648-1657
2007
Homo sapiens, Homo sapiens (Q8IWU9)
Cervo, L.; Canetta, A.; Calcagno, E.; Burbassi, S.; Sacchetti, G.; Caccia, S.; Fracasso, C.; Albani, D.; Forloni, G.; Invernizzi, R.W.
Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
J. Neurosci.
25
8165-8172
2005
Mus musculus
Ogawa, S.; Ichinose, H.
Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity
Neurosci. Lett.
401
261-265
2006
Homo sapiens (Q8IWU9), Homo sapiens
Hong, K.W.; Sugawara, Y.; Hasegawa, H.; Hayasaka, I.; Hashimoto, R.; Ito, S.; Inoue-Murayama, M.
A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats
Neurosci. Lett.
412
195-200
2007
Callithrix jacchus, Gorilla gorilla, Homo sapiens, Macaca fuscata, Pan troglodytes, Pongo pygmaeus, Rattus norvegicus, Cephalopachus bancanus, Otolemur crassicaudatus, Hylobates agilis, Mandrillus sphinx
Gacek, P.; Conner, T.S.; Tennen, H.; Kranzler, H.R.; Covault, J.
Tryptophan hydroxylase 2 gene and alcohol use among college students
Addict. Biol.
13
440-448
2008
Homo sapiens (P17752)
Wilson, S.T.; Stanley, B.; Brent, D.A.; Oquendo, M.A.; Huang, Y.Y.; Mann, J.J.
The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder
Am. J. Med. Genet.
150B
202-208
2008
Homo sapiens
Izikki, M.; Hanoun, N.; Marcos, E.; Savale, L.; Barlier-Mur, A.M.; Saurini, F.; Eddahibi, S.; Hamon, M.; Adnot, S.
Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice
Am. J. Physiol. Lung Cell. Mol. Physiol.
293
L1045-L1052
2007
Mus musculus
Lin, Y.M.; Chao, S.C.; Chen, T.M.; Lai, T.J.; Chen, J.S.; Sun, H.S.
Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese
Arch. Gen. Psychiatry
64
1015-1024
2007
Homo sapiens (P17752), Homo sapiens (Q8IWU9), Homo sapiens
Niimi, K.; Takahashi, E.; Itakura, C.
Emotional behavior and expression patterns of tyrosine hydroxylase and tryptophan hydroxylase in senescence-accelerated mouse (SAM) P6 mice
Behav. Brain Res.
188
329-336
2008
Mus musculus
Winge, I.; McKinney, J.A.; Ying, M.; DSantos, C.S.; Kleppe, R.; Knappskog, P.M.; Haavik, J.
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding
Biochem. J.
410
195-204
2008
Homo sapiens (Q8IWU9), Homo sapiens
Scheuch, K.; Lautenschlager, M.; Grohmann, M.; Stahlberg, S.; Kirchheiner, J.; Zill, P.; Heinz, A.; Walther, D.J.; Priller, J.
Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
Biol. Psychiatry
62
1288-1294
2007
Homo sapiens, Rattus norvegicus (Q8CGU9)
Lopez de Lara, C.; Brezo, J.; Rouleau, G.; Lesage, A.; Dumont, M.; Alda, M.; Benkelfat, C.; Turecki, G.
Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression
Biol. Psychiatry
62
72-80
2007
Homo sapiens (Q8IWU9), Homo sapiens
Reuter, M.; Esslinger, C.; Montag, C.; Lis, S.; Gallhofer, B.; Kirsch, P.
A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: A genetic imaging study
Biol. Psychol.
79
111-117
2008
Homo sapiens (Q8IWU9)
Canli, T.; Congdon, E.; Todd Constable, R.; Lesch, K.P.
Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing
Biol. Psychol.
79
118-125
2008
Homo sapiens (Q8IWU9)
Bao, X.; Tian, X.; Zhao, Z.; Qu, Y.; Wang, B.; Zhang, J.; Liu, T.; Yang, L.; Lv, J.; Song, C.
Immunohistochemical evidence for the presence of tryptophan hydroxylase in the brains of insects as revealed by sheep anti-tryptophan hydroxylase polyclonal antibody
Cell Tissue Res.
332
555-563
2008
Blattella germanica, Drosophila melanogaster, Antheraea pernyi, Harmonia axyridis, Childrena zenobia, Camponotus japonicus
Pennati, R.; Candiani, S.; Biggiogero, M.; Zega, G.; Groppelli, S.; Oliveri, D.; Parodi, M.; De Bernardi, F.; Pestarino, M.
Developmental expression of tryptophan hydroxylase gene in Ciona intestinalis
Dev. Genes Evol.
217
307-313
2007
Ciona intestinalis (A1Y9J6), Ciona intestinalis
Malek, Z.S.; Sage, D.; Pevet, P.; Raison, S.
Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity
Endocrinology
148
5165-5172
2007
Rattus norvegicus (Q8CGU9)
Cichon, S.; Winge, I.; Mattheisen, M.; Georgi, A.; Karpushova, A.; Freudenberg, J.; Freudenberg-Hua, Y.; Babadjanova, G.; Van Den Bogaert, A.; Abramova, L.I.; Kapiletti, S.; Knappskog, P.M.; McKinney, J.; Maier, W.; Jamra, R.A.; Schulze, T.G.; Schumacher, J.; Propping, P.; Rietschel, M.; Haavik, J.
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
Hum. Mol. Genet.
17
87-97
2008
Homo sapiens (Q8IWU9), Homo sapiens
Gizatullin, R.; Zaboli, G.; Joensson, E.G.; Asberg, M.; Leopardi, R.
The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression
J. Affect. Disord.
107
175-179
2008
Homo sapiens (P17752), Homo sapiens (Q8IWU9), Homo sapiens
Porter, R.J.; Mulder, R.T.; Joyce, P.R.; Miller, A.L.; Kennedy, M.
Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression
J. Affect. Disord.
109
209-212
2008
Homo sapiens (P17752), Homo sapiens
Patel, P.D.; Bochar, D.A.; Turner, D.L.; Meng, F.; Mueller, H.M.; Pontrello, C.G.
Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif
J. Biol. Chem.
282
26717-26724
2007
Rattus norvegicus (Q8CGU9), Homo sapiens (Q8IWU9), Homo sapiens
Murphy, K.L.; Zhang, X.; Gainetdinov, R.R.; Beaulieu, J.M.; Caron, M.G.
A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression
J. Biol. Chem.
283
13216-13224
2008
Homo sapiens (Q8IWU9)
Reuter, M.; Ott, U.; Vaitl, D.; Hennig, J.
Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene
J. Cogn. Neurosci.
19
401-408
2007
Homo sapiens (Q8IWU9)
Rhim, Y.T.; Kim, H.; Yoon, S.J.; Kim, S.S.; Chang, H.K.; Lee, T.H.; Lee, H.H.; Shin, M.C.; Shin, M.S.; Kim, C.J.
Effect of Acanthopanax senticosus on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats
J. Ethnopharmacol.
114
38-43
2007
Rattus norvegicus
Shi, Z.C.; Devasagayaraj, A.; Gu, K.; Jin, H.; Marinelli, B.; Samala, L.; Scott, S.; Stouch, T.; Tunoori, A.; Wang, Y.; Zang, Y.; Zhang, C.; Kimball, S.D.; Main, A.J.; Sun, W.; Yang, Q.; Nouraldeen, A.; Yu, X.Q.; Buxton, E.; Patel, S.; Nguyen, N.; Swaffield, J.; Powell, D.R.; Wilson, A.; Liu, Q.
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders
J. Med. Chem.
51
3684-3687
2008
Mus musculus
Tenner, K.; Walther, D.; Bader, M.
Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization
J. Neurochem.
102
1887-1894
2007
Homo sapiens
Calcagno, E.; Canetta, A.; Guzzetti, S.; Cervo, L.; Invernizzi, R.W.
Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity
J. Neurochem.
103
1111-1120
2007
Mus musculus
Kuhn, D.M.; Sakowski, S.A.; Geddes, T.J.; Wilkerson, C.; Haycock, J.W.
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II
J. Neurochem.
103
1567-1573
2007
Homo sapiens
Lenicov, F.R.; Lemonde, S.; Czesak, M.; Mosher, T.M.; Albert, P.R.
Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization
J. Neurochem.
103
2047-2057
2007
Rattus norvegicus, Homo sapiens (Q8IWU9)
Liu, Q.; Yang, Q.; Sun, W.; Vogel, P.; Heydorn, W.; Yu, X.Q.; Hu, Z.; Yu, W.; Jonas, B.; Pineda, R.; Calderon-Gay, V.; Germann, M.; ONeill, E.; Brommage, R.; Cullinan, E.; Platt, K.; Wilson, A.; Powell, D.; Sands, A.; Zambrowicz, B.; Shi, Z.C.
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
J. Pharmacol. Exp. Ther.
325
47-55
2008
Mus musculus
Barbosa, R.; Scialfa, J.H.; Terra, I.M.; Cipolla-Neto, J.; Simonneaux, V.; Afeche, S.C.
Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland
Life Sci.
82
529-535
2008
Rattus norvegicus
Peter, J.; Alenina, N.; Bader, M.; Walther, D.J.
Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
Mol. Cell. Biochem.
295
205-215
2007
Mus musculus
Nakamura, K.; Hasegawa, H.
Developmental role of tryptophan hydroxylase in the nervous system
Mol. Neurobiol.
35
45-54
2007
Mus musculus (P17532), Mus musculus (Q8CGV2), Homo sapiens (P17752), Homo sapiens (Q8IWU9)
Lim, J.E.; Pinsonneault, J.; Sadee, W.; Saffen, D.
Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons
Mol. Psychiatry
12
491-501
2007
Homo sapiens (Q8IWU9), Homo sapiens
Clark, J.A.; Flick, R.B.; Pai, L.Y.; Szalayova, I.; Key, S.; Conley, R.K.; Deutch, A.Y.; Hutson, P.H.; Mezey, E.
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice
Mol. Psychiatry
13
498-506
2008
Mus musculus, Rattus norvegicus (Q8CGU9), Homo sapiens (Q8IWU9), Homo sapiens, Mus musculus C57BL/6
Bach-Mizrachi, H.; Underwood, M.D.; Tin, A.; Ellis, S.P.; Mann, J.J.; Arango, V.
Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
Mol. Psychiatry
13
507-13, 465
2008
Homo sapiens (Q8IWU9)
Haghighi, F.; Bach-Mizrachi, H.; Huang, Y.Y.; Arango, V.; Shi, S.; Dwork, A.J.; Rosoklija, G.; Sheng, H.T.; Morozova, I.; Ju, J.; Russo, J.J.; Mann, J.J.
Genetic architecture of the human tryptophan hydroxylase 2 gene: existence of neural isoforms and relevance for major depression
Mol. Psychiatry
13
813-820
2008
Homo sapiens (Q8IWU9), Homo sapiens
Zill, P.; Preuss, U.W.; Koller, G.; Bondy, B.; Soyka, M.
SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
Neuropsychopharmacology
32
1687-1694
2007
Homo sapiens (Q8IWU9), Homo sapiens
Xu, C.X.; Liu, H.T.; Wang, J.
Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord
Neurosci. Bull.
24
29-33
2008
Rattus norvegicus
Nishimura, K.; Kitamura, Y.; Inoue, T.; Umesono, Y.; Yoshimoto, K.; Takeuchi, K.; Taniguchi, T.; Agata, K.
Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
Neurosci. Res.
59
101-106
2007
Dugesia japonica (A7VKD9), Dugesia japonica
Watanabe, Y.; Nunokawa, A.; Kaneko, N.; Someya, T.
The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia: a moderate-scale case-control study and meta-analysis
Neurosci. Res.
59
322-326
2007
Homo sapiens
Shishkina, G.T.; Kalinina, T.S.; Dygalo, N.N.
Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect
Neuroscience
150
404-412
2007
Rattus norvegicus (Q8CGU9)
Bonkale, W.L.; Austin, M.C.
3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus
Neuroscience
155
270-276
2008
Rattus norvegicus
Chen, G.L.; Miller, G.M.
Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability
Neuroscience
155
485-491
2008
no activity in Rattus norvegicus, Macaca mulatta (Q2HZ26), Macaca mulatta
Tzvetkov, M.V.; Brockmoeller, J.; Roots, I.; Kirchheiner, J.
Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment
Pharmacogenet. Genomics
18
495-506
2008
Homo sapiens (Q8IWU9), Homo sapiens
Ham, B.; Lee, B.; Paik, J.; Kang, R.; Choi, M.; Choi, I.; Lee, M.
Association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population
Prog. Neuropsychopharmacol. Biol. Psychiatry
31
104-107
2007
Homo sapiens (P17752), Homo sapiens
Nielsen, M.S.; Petersen, C.R.; Munch, A.; Vendelboe, T.V.; Boesen, J.; Harris, P.; Christensen, H.E.
A simple two step procedure for purification of the catalytic domain of chicken tryptophan hydroxylase 1 in a form suitable for crystallization
Protein Expr. Purif.
57
116-126
2008
Gallus gallus (P70080), Gallus gallus
Saitoh, A.; Yamaguchi, K.; Tatsumi, Y.; Murasawa, H.; Nakatani, A.; Hirose, N.; Yamada, M.; Yamada, M.; Kamei, J.
Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats
Psychopharmacology
191
857-865
2007
Rattus norvegicus
Kulikov, A.V.; Osipova, D.V.; Popova, N.K.
The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain
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Mus musculus (Q8CGV2)
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Hofto, L.R.; Lee, C.E.; Cafiero, M.
The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactionsin tryptophan hydroxylase and aromatic amino acid decarboxylase
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synthetic construct
Kino, K.; Hara, R.; Nozawa, A.
Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum
J. Biosci. Bioeng.
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2009
Homo sapiens (P17752)
Windahl, M.S.; Petersen, C.R.; Christensen, H.E.; Harris, P.
Crystal structure of tryptophan hydroxylase with bound amino acid substrate
Biochemistry
47
12087-12094
2008
Gallus gallus (P70080), Gallus gallus
Jin, H.; Cianchetta, G.; Devasagayaraj, A.; Gu, K.; Marinelli, B.; Samala, L.; Scott, S.; Stouch, T.; Tunoori, A.; Wang, Y.; Zang, Y.; Zhang, C.; David Kimball, S.; Main, A.J.; Ding, Z.M.; Sun, W.; Yang, Q.; Yu, X.Q.; Powell, D.R.; Wilson, A.; Liu, Q.; Shi, Z.C.
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors
Bioorg. Med. Chem. Lett.
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5229-5232
2009
Mus musculus, Homo sapiens (P17752)
Heydendael, W.; Jacobson, L.
Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphe tryptophan hydroxylase gene expression
Brain Res.
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2009
Mus musculus
McKinney, J.A.; Turel, B.; Winge, I.; Knappskog, P.M.; Haavik, J.
Functional properties of missense variants of human tryptophan hydroxylase 2
Hum. Mutat.
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Homo sapiens (P17752), Homo sapiens
Kurosawa, N.; Hirata, T.; Suzuki, H.
Characterization of putative tryptophan monooxygenase from Ralstonia solanacearum
J. Biochem.
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2009
Ralstonia solanacearum
Rahman, M.S.; Thomas, P.
Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia
Neuroscience
158
751-765
2009
Micropogonias undulatus (B3VBU9), Micropogonias undulatus (B3VBV0), Micropogonias undulatus
Windahl, M.; Boesen, J.; Karlsen, P.; Christensen, H.
Expression, purification and enzymatic characterization of the catalytic domains of human tryptophan hydroxylase isoforms
Protein J.
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400-406
2009
Homo sapiens (P17752), Homo sapiens (Q8IWU9), Homo sapiens
Pavon, J.A.; Eser, B.; Huynh, M.T.; Fitzpatrick, P.F.
Single turnover kinetics of tryptophan hydroxylase: evidence for a new intermediate in the reaction of the aromatic amino acid hydroxylases
Biochemistry
49
7563-7571
2010
Oryctolagus cuniculus
Calvo, A.C.; Scherer, T.; Pey, A.L.; Ying, M.; Winge, I.; McKinney, J.; Haavik, J.; Thoeny, B.; Martinez, A.
Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2
J. Neurochem.
114
853-863
2010
Homo sapiens
Kuhn, D.M.; Sykes, C.E.; Geddes, T.J.; Jaunarajs, K.L.; Bishop, C.
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinsons disease
J. Neurochem.
116
426-437
2011
Mus musculus
Matthes, S.; Mosienko, V.; Bashammakh, S.; Alenina, N.; Bader, M.
Tryptophan hydroxylase as novel target for the treatment of depressive disorders
Pharmacology
85
95-109
2010
Homo sapiens, Mus musculus
Ren, G.; Li, S.; Zhong, H.; Lin, S.
Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase
J. Biol. Chem.
288
22451-22459
2013
Danio rerio
Rotberg, B.; Kronenberg, S.; Carmel, M.; Frisch, A.; Brent, D.; Zalsman, G.; Apter, A.; Weizman, A.
Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders
J. Child Adolesc. Psychopharmacol.
23
117-122
2013
Homo sapiens
Nowak, E.C.; de Vries, V.C.; Wasiuk, A.; Ahonen, C.; Bennett, K.A.; Le Mercier, I.; Ha, D.G.; Noelle, R.J.
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
J. Exp. Med.
209
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2012
Mus musculus
Zhang, S.; Hinck, C.S.; Fitzpatrick, P.F.
The regulatory domain of human tryptophan hydroxylase 1 forms a stable dimer
Biochem. Biophys. Res. Commun.
476
457-461
2016
Homo sapiens
Laurent, L.; Deroy, K.; St-Pierre, J.; Cote, F.; Sanderson, J.T.; Vaillancourt, C.
Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase
Biochimie
140
159-165
2017
Homo sapiens, Mus musculus
Goldberg, D.R.; De Lombaert, S.; Aiello, R.; Bourassa, P.; Barucci, N.; Zhang, Q.; Paralkar, P.; Valentine, J.; Zavadoski, W.
Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors
Bioorg. Med. Chem. Lett.
26
1124-1129
2016
Rattus norvegicus
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Goldberg, D.R.; De Lombaert, S.; Aiello, R.; Bourassa, P.; Barucci, N.; Zhang, Q.; Paralkar, V.; Stein, A.J.; Valentine, J.; Zavadoski, W.
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
Bioorg. Med. Chem. Lett.
26
2855-2860
2016
Homo sapiens
Tidemand, K.; Christensen, H.; Hoeck, N.; Harris, P.; Boesen, J.; Peters, G.
Stabilization of tryptophan hydroxylase 2 by L-phenylalanine-induced dimerization
FEBS Open Bio
6
987-999
2016
Homo sapiens
Petrassi, M.; Barber, R.; Be, C.; Beach, S.; Cox, B.; DSouza, A.M.; Duggan, N.; Hussey, M.; Fox, R.; Hunt, P.; Jarai, G.; Kosaka, T.; Oakley, P.; Patel, V.; Press, N.; Rowlands, D.; Scheufler, C.; Schmidt, O.; Srinivas, H.; Turner, M.; Turner, R.; Westwick, J.; Wolfreys, A.; Pathan, N.; Watson, S.; Thomas, M.
Identification of a novel allosteric inhibitory site on tryptophan hydroxylase 1 enabling unprecedented selectivity over all related hydroxylases
Front. Pharmacol.
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240
2017
Homo sapiens
Iida, H.; Ogihara, T.; Min, M.K.; Hara, A.; Kim, Y.G.; Fujimaki, K.; Tamaki, M.; Fujitani, Y.; Kim, H.; Watada, H.
Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy
J. Mol. Endocrinol.
55
41-53
2015
Mus musculus
Lambrus, B.G.; Cochet-Escartin, O.; Gao, J.; Newmark, P.A.; Collins, E.M.; Collins, J.J.
Tryptophan hydroxylase is required for eye melanogenesis in the planarian Schmidtea mediterranea
PLoS ONE
10
e0127074
2015
Schmidtea mediterranea
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