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Disease on EC 1.14.15.3 - alkane 1-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.
Inhibition of 25-hydroxyvitamin D3-1-hydroxylase by chronic metabolic acidosis.
Adenocarcinoma
Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma.
Overexpression of the heme oxygenase gene in renal cell carcinoma.
Albuminuria
Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats.
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
alkane 1-monooxygenase deficiency
Association of a CYP4A11 variant and blood pressure in black men.
Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans.
Ascorbic Acid Deficiency
[Effect of ascorbic acid on 25-hydroxyvitamin D3 metabolism in the kidneys and 1,25-dihydroxyvitamin D3 reception in the small intestine mucosa of guinea pigs]
Asthma
Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.
Bacterial Infections
Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes.
Brain Ischemia
Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke.
Breast Neoplasms
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Carcinogenesis
An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action.
Carcinoma
Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition.
Carcinoma, Hepatocellular
CYP4A11 is repressed by retinoic acid in human liver cells.
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors.
Genistein, Resveratrol, and 5-Aminoimidazole-4-carboxamide-1-{beta}-D-ribofuranoside Induce Cytochrome P450 4F2 Expression through an AMP-Activated Protein Kinase-Dependent Pathway.
Carcinoma, Renal Cell
Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
Cardiomegaly
3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats.
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
Cardiovascular Diseases
Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice.
Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.
Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications.
Cerebral Infarction
Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject.
Cerebrovascular Disorders
Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases.
Colitis
Mice Deficient in Cyp4a14 Have An Increased Number of Goblet Cells and Attenuated Dextran Sulfate Sodium-Induced Colitis.
Coronary Artery Disease
A Novel Polymorphism in the Promoter of the
A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease.
CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease-The ENCORE Trials.
Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.
Craniocerebral Trauma
Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia.
Death, Sudden, Cardiac
Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia.
Diabetes Mellitus, Type 1
Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.
Diabetes Mellitus, Type 2
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Diabetic Nephropathies
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.
SiRNA-Cyp4a14 and diabetic nephropathy: silencing of Cyp4a14 by siRNA inhibits proliferation and fibrosis of mesangial cells.
Dyslipidemias
The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction.
Endotoxemia
Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent.
Essential Hypertension
A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men.
Association between the CYP4A11 T8590C variant and essential hypertension: new data from han chinese and a meta-analysis.
Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population.
CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population.
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
Fatty Liver
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Etiopathogenesis of nonalcoholic steatohepatitis.
MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement.
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
The direction of cross affects [corrected] obesity after puberty in male but not female offspring.
Glioma
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.
Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma.
Gliosarcoma
9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.
Glucose Intolerance
The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction.
Gout
Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout.
Hematuria
Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease.
Hemorrhagic Stroke
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Hepatitis, Chronic
Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein.
Hepatomegaly
Bifonazole, but not the structurally-related clotrimazole, induces both peroxisome proliferation and members of the cytochrome P4504A sub-family in rat liver.
Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat.
Hypercalcemia
Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy.
Hyperglycemia
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
Hyperparathyroidism
[Serum concentrations of 1,25-dihydroxyvitamin D in cases of osteomalacia, parathyroid dysfunction and idiopathic hypercalciuria]
Hyperparathyroidism, Primary
Substrate-product relation of 1-hydroxylase activity in primary hyperparathyroidism.
Hypertension
20-HETE and Blood Pressure Regulation: Clinical Implications.
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.
A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men.
A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population.
A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.
Aging Increases Cytochrome P450 4A Modulation of alpha1-Adrenergic Vasoconstriction in Mesenteric Arteries.
Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes.
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Altered vitamin D metabolism in the kidney of the spontaneously hypertensive rat.
Arachidonic acid ?-hydroxylase CYP4A11: inter-ethnic variations in the 8590T>C loss-of-function variant.
Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.
Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China.
Association of a CYP4A11 variant and blood pressure in black men.
Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction.
Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy.
Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension.
CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow.
Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney.
Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension.
Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ?-hydroxylation.
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Genetic associations with hypertension: meta-analyses of six candidate genetic variants.
Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.
Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases.
Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans.
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice.
Lifelong inorganic arsenic compounds consumption affected blood pressure in rats.
Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.
Peroxisome Proliferator Activated Receptor-? Agonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice.
Peroxisome Proliferator-Activated Receptor-? Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension.
Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity.
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.
Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats.
Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat.
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
T8590C polymorphism of CYP4A11 is a risk factor for hypertension: a meta-analysis.
The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance.
The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss.
The relationship between CYP4A11 and human hypertension.
The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis.
The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction.
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.
[Altered expressions of alkane monooxygenase and hypoxia inducible factor-1? expression in lung tissue of rat hypoxic pulmonary hypertension].
Hyperthyroidism
Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone.
Hypocalcemia
Effect of vitamin D3 administration on serum 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and osteocalcin in vitamin D-deficient elderly people.
Hypoparathyroidism
Vitamin D metabolism in hyperthyroidism.
[Serum concentrations of 1,25-dihydroxyvitamin D in cases of osteomalacia, parathyroid dysfunction and idiopathic hypercalciuria]
Hypophosphatemia
Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity.
Infections
Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Insulin Resistance
Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population.
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats.
Ischemic Stroke
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Kidney Diseases
Association of a CYP4A11 variant and blood pressure in black men.
Liver Cirrhosis
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Liver Diseases
CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
Toxicogenomics directory of chemically exposed human hepatocytes.
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Liver Diseases, Alcoholic
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Liver Neoplasms
Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study).
Lung Diseases
Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease.
Lung Injury
The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.
Melanoma
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Metabolic Diseases
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Myocardial Infarction
Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction.
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
Haplotype-based case-control study of CYP4A11 gene and myocardial infarction.
Neoplasm Metastasis
Co-expression network analysis identified six hub genes in association with metastasis risk and prognosis in hepatocellular carcinoma.
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Neoplasms
20-HETE-producing enzymes are up-regulated in human cancers.
9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.
Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action.
Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats.
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation.
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Cytochrome P450 ?-Hydroxylases in Inflammation and Cancer.
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity.
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma.
Integrated Proteomics and Bioinformatics to Identify Potential Prognostic Biomarkers in Hepatocellular Carcinoma.
On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.
Overexpression of the heme oxygenase gene in renal cell carcinoma.
Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy.
Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats.
Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.
The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance.
The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages.
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
Nephrosclerosis
Association of a CYP4A11 variant and blood pressure in black men.
Non-alcoholic Fatty Liver Disease
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.
Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model.
Obesity
Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Osteomalacia
Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity.
Pre-Eclampsia
Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia.
Proteinuria
Association of a CYP4A11 variant and blood pressure in black men.
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.
Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease.
Pulmonary Arterial Hypertension
[Altered expressions of alkane monooxygenase and hypoxia inducible factor-1? expression in lung tissue of rat hypoxic pulmonary hypertension].
Renal Insufficiency
Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease.
Reperfusion Injury
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
Rickets
Normal 24-hydroxylation of vitamin D metabolites in patients with vitamin D-dependency rickets type I. Structural implications for the vitamin D hydroxylases.
The effects of 1,25-dihydroxyvitamin D-3 deficiency on Ca(2+)-transport and Ca(2+)-uptake into brush-border membrane vesicles from pig small intestine.
[Insufficiency and excess of vitamin D activity (author's transl)]
Starvation
Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes.
Stroke
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss.
Tuberculosis
Functional analysis of alkane hydroxylases from gram-negative and gram-positive bacteria.
The alkane hydroxylase gene of Burkholderia cepacia RR10 is under catabolite repression control.
Uremia
1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Clinical studies on prophylaxis and treatment of secondary hyperparathyroidism in uremic patients on chronic dialysis.
Varicose Veins
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis.
Vitamin B 6 Deficiency
[Vitamin D and calcium metabolism in relation to different levels of vitamins B6 and D]
Vitamin D Deficiency
Deficiency of vitamin D metabolites directly stimulates renal 25-hydroxyvitamin D3-1-hydroxylase activity in rats.
Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats.
Regulation of the ferredoxin component of renal hydroxylases at transcriptional and postranslational levels and of the protein inhibitor of cyclic AMP-dependent kinase.
Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice.
Vitamin D deficiency in rats with normal serum calcium concentrations.