Disease on EC 1.14.15.16 - vitamin D3 24-hydroxylase
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Abortion, Spontaneous
Comparable vitamin D3 metabolism in the endometrium of patients with recurrent spontaneous abortion and fertile controls.
Acidosis
Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism.
Acidosis
Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.
Acute Kidney Injury
Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency.
Adenocarcinoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Adenoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Alopecia
Analysis of the relation between alopecia and resistance to 1,25-dihydroxyvitamin D.
Alzheimer Disease
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
Alzheimer Disease
Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.
Ascorbic Acid Deficiency
[Effect of ascorbic acid on 25-hydroxyvitamin D3 metabolism in the kidneys and 1,25-dihydroxyvitamin D3 reception in the small intestine mucosa of guinea pigs]
Bone Resorption
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease.
Bone Resorption
The effects of MC903 on 1,25-(OH)2D3 receptor binding, 24-hydroxylase activity and in vitro bone resorption.
Breast Neoplasms
25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer.
Breast Neoplasms
25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue.
Breast Neoplasms
A highly sensitive method for large-scale measurements of 1,25-dihydroxyvitamin D.
Breast Neoplasms
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Breast Neoplasms
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Breast Neoplasms
Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
Breast Neoplasms
The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.
Breast Neoplasms
Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter.
Breast Neoplasms
Vitamin D-1alpha-hydroxylase and vitamin D-24-hydroxylase in benign and malign breast tissue.
Breast Neoplasms
Vitamin D-24-hydroxylase in benign and malignant breast tissue and cell lines.
Carcinoma
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Carcinoma
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Carcinoma
In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D3.
Carcinoma
Responsiveness of human carcinoma cells of gynecologic origin to 1,25-dihydroxycholecalciferol.
Carcinoma
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.
Colonic Neoplasms
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Colonic Neoplasms
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
Colonic Neoplasms
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Colonic Neoplasms
Expression of 25-hydroxyvitamin D3-24-hydroxylase activity in Caco-2 cells. An in vitro model of intestinal vitamin D catabolism.
Colorectal Neoplasms
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Colorectal Neoplasms
Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
Dehydration
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Diabetic Nephropathies
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure.
Endometrial Neoplasms
Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.
Endometriosis
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Familial Hypophosphatemic Rickets
Abnormal 24-hydroxylation of 25-hydroxyvitamin D in the X-linked hypophosphatemic mouse.
Familial Hypophosphatemic Rickets
Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets.
Familial Hypophosphatemic Rickets
Plasma 24,25-dihydroxyvitamin D3 concentrations in X-linked hypophosphatemic mice: studies using mass fragmentographic and radioreceptor assays.
Genetic Diseases, Inborn
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Hypercalcemia
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Hypercalcemia
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Hypercalcemia
Do the Heterozygous Carriers of a CYP24A1 Mutation Display a Different Biochemical Phenotype Than Wild Types?
Hypercalcemia
Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia.
Hypercalcemia
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Hypercalcemia
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Hypercalcemia
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Hypercalcemia
Molecular characterization of a recurrent 10.9?kb CYP24A1 deletion in Idiopathic Infantile Hypercalcemia.
Hypercalcemia
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Hypercalcemia
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Hypercalcemia
Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.
Hypercalcemia
[Hypercalcemia and inactive mutation of CYP24A1. Case-study and literature review].
Hyperparathyroidism
Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin d.
Hyperparathyroidism, Secondary
E-pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for chronic kidney disease.
Hyperparathyroidism, Secondary
Early lethality in Hyp mice with targeted deletion of Pth gene.
Hyperparathyroidism, Secondary
Regulation of messenger ribonucleic acid expression of 1 alpha,25-dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts.
Hypoalbuminemia
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure.
Hypocalcemia
25-Hydroxyvitamin D 1 alpha- and 24-hydroxylase activities in pig kidney homogenates: effect of vitamin D deficiency.
Hypocalcemia
Regulation of renal vitamin D receptor is an important determinant of 1alpha,25-dihydroxyvitamin D(3) levels in vivo.
Hypoparathyroidism
24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs.
Hypophosphatemia
Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice.
Infections
In vivo activation of the intracrine vitamin d pathway in innate immune cells and mammary tissue during a bacterial infection.
Infections
Vitamin D receptor and 1?-hydroxylase are highly expressed in lungs of mice infected with H9N2 avian influenza viruses.
Kidney Calculi
Idiopathic infantile hypercalcemia: case report and review of the literature.
Kidney Calculi
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Kidney Failure, Chronic
Chronic hypercalcaemia from inactivating mutations of vitamin D 24-hydroxylase (CYP24A1): implications for mineral metabolism changes in chronic renal failure.
Kidney Failure, Chronic
Potentiated 1,25(OH)2D3-induced 24-hydroxylase gene expression in uremic rat intestine.
Leiomyoma
Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes.
Leukemia
Biological activities of 19-nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring.
Leukemia
Dibutyryl cAMP enhances the effect of 1,25-dihydroxyvitamin D3 on a human promyelocytic leukemia cell, HL-60, at both the receptor and the postreceptor steps.
Leukemia
Effect of uremic serum on 1,25-dihydroxyvitamin D3-induced differentiation of human promyelocytic leukemia cell, HL-60.
Leukemia
Effects of uremic serum on 1,25-dihydroxyvitamin D3-induced differentiation of a human promyelocytic leukemia cell line, HL-60.
Leukemia
Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60).
Leukemia, Myeloid
Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60).
Lung Neoplasms
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
Melanoma
Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro.
Melanoma
In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.
Neoplasm Metastasis
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Neoplasms
25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer.
Neoplasms
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Neoplasms
A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cells.
Neoplasms
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
Neoplasms
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
Neoplasms
Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.
Neoplasms
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
Neoplasms
Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells.
Neoplasms
MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways.
Neoplasms
Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention.
Neoplasms
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients.
Neoplasms
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
Neoplasms
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Neoplasms
Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
Neoplasms
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Neoplasms
Responsiveness of human carcinoma cells of gynecologic origin to 1,25-dihydroxycholecalciferol.
Neoplasms
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Neoplasms
Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.
Nephrocalcinosis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Nephrocalcinosis
Idiopathic infantile hypercalcemia: case report and review of the literature.
Nephrocalcinosis
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Nephrocalcinosis
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Nephrolithiasis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Nephrolithiasis
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Nephrolithiasis
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Osteosarcoma
A highly sensitive method for large-scale measurements of 1,25-dihydroxyvitamin D.
Osteosarcoma
Biological activity profiles of 1alpha,25-dihydroxyvitamin D2, D3, D4, D7, and 24-epi-1alpha,25-dihydroxyvitamin D2.
Osteosarcoma
Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement.
Osteosarcoma
Retinoid X receptor isotype identity directs human vitamin D receptor heterodimer transactivation from the 24-hydroxylase vitamin D response elements in yeast.
Ovarian Neoplasms
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Ovarian Neoplasms
Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells.
Premature Birth
Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births.
Prostatic Neoplasms
Androgen enhances the antiproliferative activity of vitamin D3 by suppressing 24-hydroxylase expression in LNCaP cells.
Prostatic Neoplasms
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
Prostatic Neoplasms
Liarozole Acts Synergistically with 1?,25-Dihydroxyvitamin D3 to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity.
Prostatic Neoplasms
Liarozole acts synergistically with 1alpha,25-dihydroxyvitamin D3 to inhibit growth of DU 145 human prostate cancer cells by blocking 24-hydroxylase activity.
Prostatic Neoplasms
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.
Proteinuria
Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.
Renal Insufficiency
Effect of vitamin D metabolites on calcitriol degradative enzymes in renal failure.
Renal Insufficiency
Idiopathic infantile hypercalcemia: case report and review of the literature.
Renal Insufficiency, Chronic
Assessment of 24,25(OH)(2)D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Rickets
25-Hydroxyvitamin D-24-hydroxylase in phytohemagglutinin-stimulated lymphocytes: intermediate bioresponse to 1,25-dihydroxyvitamin D3 of cells from parents of patients with vitamin D-dependent rickets type II.
Rickets
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.
Rickets
Impaired stimulation of 25-hydroxyvitamin D-24-hydroxylase in fibroblasts from a patient with vitamin D-dependent rickets, type II. A form of receptor-positive resistance to 1,25-dihydroxyvitamin D3.
Rickets
Normal 24-hydroxylation of vitamin D metabolites in patients with vitamin D-dependency rickets type I. Structural implications for the vitamin D hydroxylases.
Rickets
Vitamin D-dependent rickets type II. Defective induction of 25-hydroxyvitamin D3-24-hydroxylase by 1,25-dihydroxyvitamin D3 in cultured skin fibroblasts.
Sarcoidosis
Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis.
Sarcoidosis
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Thyroid Neoplasms
Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism.
Tooth Resorption
Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats.
Tuberculosis
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Uremia
Potentiated 1,25(OH)2D3-induced 24-hydroxylase gene expression in uremic rat intestine.
Vitamin D Deficiency
25-Hydroxyvitamin D 1 alpha- and 24-hydroxylase activities in pig kidney homogenates: effect of vitamin D deficiency.
Vitamin D Deficiency
Regulation of 25-OH-D3 1 alpha-hydroxylase and 24-hydroxylase activities along the rat nephron and in isolated kidney cells.
Vitamin D Deficiency
Regulation of calf renal 25-hydroxyvitamin D-hydroxylase activities by calcium-regulating hormones.
Vitamin D Deficiency
Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.
Vitamin D Deficiency
[Hypercalcemia and inactive mutation of CYP24A1. Case-study and literature review].
vitamin d3 24-hydroxylase deficiency
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
vitamin d3 24-hydroxylase deficiency
Simultaneous determination of 24,25- and 25,26-dihydroxyvitamin D3 in serum samples with liquid-chromatography mass spectrometry - A useful tool for the assessment of vitamin D metabolism.
Wilms Tumor
VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells.
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