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Disease on EC 1.14.14.94 - leukotriene-B4 20-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Acute Coronary Syndrome
Factors associated with platelet reactivity during dual antiplatelet therapy in patients with diabetes after acute coronary syndrome.
The ABCB1, CYP2C19, CYP3A5 and CYP4F2 genetic polymorphisms and platelet reactivity in the early phases of acute coronary syndromes.
Adenocarcinoma
Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma.
Adrenoleukodystrophy
CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids.
Angina Pectoris
New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.
Angina, Stable
New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.
Atherosclerosis
Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene.
New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.
Atrial Fibrillation
A new algorithm to predict warfarin dose from polymorphisms of CYP4F2 , CYP2C9 and VKORC1 and clinical variables: derivation in Han Chinese patients with non valvular atrial fibrillation.
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Impact of VKORC1, CYP4F2 and NQO1 gene variants on warfarin dose requirement in Han Chinese patients with catheter ablation for atrial fibrillation.
The impact of CYP4F2, ABCB1, and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation.
Bacterial Infections
Signatures of selection reveal candidate genes involved in economic traits and cold acclimation in five Swedish cattle breeds.
Breast Neoplasms
CYP2W1, CYP4F11 and CYP8A1 polymorphisms and interaction of CYP2W1 genotypes with risk factors in Mexican women with breast cancer.
Carcinogenesis
Differential modulation of leukotriene B4 synthesis and degradation in human bronchoalveolar lavage cells by lipopolysaccharide and tobacco smoke.
Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
Carcinoma
Regulation of cytochrome P450 4F11 by nuclear transcription factor-?B.
Carcinoma, Hepatocellular
Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.
Genistein, Resveratrol, and 5-Aminoimidazole-4-carboxamide-1-{beta}-D-ribofuranoside Induce Cytochrome P450 4F2 Expression through an AMP-Activated Protein Kinase-Dependent Pathway.
Carcinoma, Non-Small-Cell Lung
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Cardiomegaly
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
Cardiovascular Diseases
Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.
Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
Celiac Disease
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cerebral Infarction
A Haplotype of the CYP4F2 Gene is Associated With Cerebral Infarction in Japanese Men.
Cerebrovascular Disorders
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases.
Colitis
CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a.
Colitis, Ulcerative
Altered leukotriene B4 metabolism in colonic mucosa with inflammatory bowel disease.
Leukotriene B4 omega-hydroxylase activity in polymorphonuclear leukocytes from patients with inflammatory bowel disease.
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Coronary Artery Disease
A Novel Polymorphism in the Promoter of the
Association of CYP4F2 and CTRP9 polymorphisms and serum selenium levels with coronary artery disease.
Coronary Disease
CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population.
The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.
Crohn Disease
Leukotriene B4 omega-hydroxylase activity in polymorphonuclear leukocytes from patients with inflammatory bowel disease.
Diabetes Mellitus
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Diabetic Nephropathies
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.
Drug-Related Side Effects and Adverse Reactions
Genetic Association of Drug Response to Erlotinib in Chinese Advanced Non-small Cell Lung Cancer Patients.
Dyslipidemias
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Essential Hypertension
Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.
[Correlation analysis and identification of G421C in regulatory region of CYP4F2 gene with essential hypertension]
Glioma
Genetic variants of CYP4F12 gene are associated with glioma susceptibility.
Granuloma
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Heart Diseases
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Heart Failure
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Hemorrhagic Stroke
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Hepatitis C
Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.
Hyperglycemia
20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3?/Glut2 pathway.
20-HETE Induces Hyperglycemia through the cAMP/PKA-PhK-GP Pathway.
Hypertension
20-HETE and Blood Pressure Regulation: Clinical Implications.
20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3?/Glut2 pathway.
Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??
Association Between the CYP4F2 Gene rs1558139 and rs2108622 Polymorphisms and Hypertension: A Meta-Analysis.
Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.
Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension.
Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Correction to: Association Between the CYP4F2 Gene rs1558139 and rs2108622 Polymorphisms and Hypertension: A Meta-Analysis by Geng H, Li B, Wang Y, and Wang L. Genet Test Mol Biomarkers 2019;23:342-347. DOI: 10.1089/gtmb.2018.0202.
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases.
Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice.
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.
Re: "Association Between the CYP4F2 Gene rs1558139 and rs2108622 Polymorphisms and Hypertension: A Meta-Analysis" by Geng et al. (Genet Test Mol Biomarkers 2019;23:342-347; DOI: 10.1089/gtmb.2018.0202).
Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1.
Response to Gholami and Mohammad Amoli: Re: Association Between the CYP4F2 Gene rs1558139 and rs2108622 Polymorphisms and Hypertension: A Meta-Analysis by Geng et al.(Genet Test Mol Biomarkers 2019;23:342-347; DOI: 10.1089/gtmb.2018.0202).
The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss.
The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.
Ichthyosis
An update on molecular aspects of the non-syndromic ichthyoses.
Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ?-Hydroxylase Crucial to Acylceramide Production.
Ichthyosis, Lamellar
LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22.
Infections
149 PRODUCTION OF KNOCK-DOWN MICE WITH shRNA CYTOCHROME P-450 4F16 GENE AND REDUCTION OF THE IMMUNE SYSTEM.
Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Inflammatory Bowel Diseases
Leukotriene B4 omega-hydroxylase activity in polymorphonuclear leukocytes from patients with inflammatory bowel disease.
Insulin Resistance
20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3?/Glut2 pathway.
Insulinoma
20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3?/Glut2 pathway.
Ischemic Stroke
Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Correlation between CYP4F2 gene rs2108622 polymorphism and susceptibility to ischemic stroke.
CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke.
CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population.
Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
Effect of CYP2C9 *11/*11 genotype on initial and long-term warfarin dose requirement and therapeutic response.
Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke.
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level.
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.
Latent Tuberculosis
Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks.
Leukemia
Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils.
Leukodystrophy, Metachromatic
Genome at juncture of early human migration: a systematic analysis of two whole genomes and thirteen exomes from Kuwaiti population subgroup of inferred Saudi Arabian tribe ancestry.
Liver Cirrhosis
Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis.
Liver Diseases
Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis.
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.
Liver Neoplasms
Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
Lung Neoplasms
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.
Macular Degeneration
Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age-related macular degeneration.
CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration.
Metabolic Syndrome
The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.
Myocardial Infarction
A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction.
[Association on the haplotypes of CYP4F2 gene and myocardial infarction]
Myocardial Ischemia
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Neoplasms
149 PRODUCTION OF KNOCK-DOWN MICE WITH shRNA CYTOCHROME P-450 4F16 GENE AND REDUCTION OF THE IMMUNE SYSTEM.
Cytochrome P450 ?-Hydroxylases in Inflammation and Cancer.
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells.
Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma.
Right and left-sided colon cancers - specificity of molecular mechanisms in tumorigenesis and progression.
The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
Non-alcoholic Fatty Liver Disease
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.
Obesity
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Optic Neuritis
Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration.
Osteosarcoma
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.
Periapical Abscess
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Periapical Granuloma
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Prostatic Neoplasms
Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.
Psoriasis
Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions.
Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions.
Pulmonary Disease, Chronic Obstructive
The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population.
Radicular Cyst
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Reperfusion Injury
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
Skin Diseases
149 PRODUCTION OF KNOCK-DOWN MICE WITH shRNA CYTOCHROME P-450 4F16 GENE AND REDUCTION OF THE IMMUNE SYSTEM.
Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications.
Stroke
Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.
Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design (Study protocol).
The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss.
Thrombosis
Impact of genetic and clinical factors on warfarin therapy in patients early after heart valve replacement surgery.
Prosthetic valve thrombosis - association of genetic polymorphisms of VKORC1, CYP2C9 and CYP4F2 genes.
Vascular Diseases
Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.
Venous Thromboembolism
A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.
Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial.
Virus Diseases
Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.