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Information on EC 1.14.14.87 - 2-hydroxyisoflavanone synthase

for references in articles please use BRENDA:EC1.14.14.87
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IUBMB Comments
Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.
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The enzyme appears in viruses and cellular organisms
Synonyms
isoflavone synthase, gmifs1, 2-his, cyp93c2, gmifs, cyp93c, cyp93c18, ifs2-12, 2-hydroxyisoflavanone synthase 1, isoflavone synthase 2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-naringenin + O2 + [reduced NADPH-hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH-hemoprotein reductase]
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(2)
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liquiritigenin + O2 + [reduced NADPH-hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH-hemoprotein reductase]
show the reaction diagram
(1)
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