Disease on EC 1.14.14.80 - long-chain fatty acid omega-monooxygenase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Ascorbic Acid Deficiency
Ascorbic acid deficiency decreases the expression of CYP4A1 in liver microsomes of guinea pigs.
Carcinoma, Hepatocellular
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha.
Carcinoma, Hepatocellular
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.
Cardiotoxicity
Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats.
Endotoxemia
NS-398 reverses hypotension in endotoxemic rats: Contribution of eicosanoids, NO, and peroxynitrite.
Fatty Liver
Effects of binge ethanol on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease.
Fatty Liver, Alcoholic
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Glioma
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
Hepatomegaly
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR? and CAR/PXR.
Hypercholesterolemia
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes.
Hyperlipidemias
Kaempferol Regulates the Lipid-Profile in High-Fat Diet-Fed Rats through an Increase in Hepatic PPAR? Levels.
Hyperlipidemias
Regulation of Obesity and Lipid Disorders by Extracts from Angelica acutiloba Root in High-fat Diet-induced Obese Rats.
Hypertension
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Hypertension
Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure.
Hypertension
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
Hypertension
Effects of rosuvastatin correlated with the down-regulation of CYP4A1 in spontaneously hypertensive rats.
Hypertension
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.
Hypertension
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
Hypertension
Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney.
Hypertension
Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats.
Hypertension
Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats.
Hypertension
Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension.
Hyperthyroidism
Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone.
Hypotension
A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.
Hypotension
Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure.
Hypotension
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Hypotension
Contribution of PPAR?/?/?, AP-1, importin-?3, and RXR? to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Hypotension
Piroxicam Reverses Endotoxin-Induced Hypotension in Rats: Contribution of Vasoactive Eicosanoids and Nitric Oxide.
Infarction, Middle Cerebral Artery
Hyperbaric oxygenation and 20-HETE inhibition reduce stroke volume in female diabetic Sprague-Dawley rats.
Malnutrition
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Neoplasms
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Neoplasms
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
Neoplasms
Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man.
Non-alcoholic Fatty Liver Disease
CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation.
Obesity
Characterization of hepatic cytochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone.
Obesity
Regulation of Obesity and Lipid Disorders by Extracts from Angelica acutiloba Root in High-fat Diet-induced Obese Rats.
Shock, Septic
A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.
Shock, Septic
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Shock, Septic
Contribution of PPAR?/?/?, AP-1, importin-?3, and RXR? to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Tachycardia
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Tachycardia
Contribution of PPAR?/?/?, AP-1, importin-?3, and RXR? to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
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