Reference on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yoshida, T.; Kikuchi, G.
Purification and properties of heme oxygenase from rat liver microsomes
J. Biol. Chem.
254
4487-4491
1979
Rattus norvegicus
Maines, M.D.; Ibrahim, N.G.; Kappas, A.
Solubilization and partial purification of heme oxygenase from rat liver
J. Biol. Chem.
252
5900-5903
1977
Rattus norvegicus
Schacter, B.A.
Assay of microsomal heme oxygenase in liver and spleen
Methods Enzymol.
52
367-372
1978
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Bonkovsky, H.L.; Healy, J.F.; Pohl, J.
Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes
Eur. J. Biochem.
189
155-160
1990
Gallus gallus
Yoshinaga, T.; Sudo, Y.; Sano, S.
Enzymic conversion of alpha-oxyprotohaem IX into biliverdin IX alpha by haem oxygenase
Biochem. J.
270
659-664
1990
Bos taurus
Frydman, R.B.; Tomaro, M.L.; Buldain, G.; Awruch, J.; Diaz, L.; Frydman, B.
Specificity of heme oxygenase: a study with synthetic hemins
Biochemistry
20
5177-5182
1981
Rattus norvegicus
Tomaro, M.L.; Frydman, R.B.; Frydman, B.; Pandey, R.K.; Smith, K.M.
The oxidation of hemins by microsomal heme oxygenase. Structural requirements for the retention of substrate activity
Biochim. Biophys. Acta
791
342-349
1984
Rattus norvegicus
Maines, M.D.; Kappas, A.
Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action
Biochemistry
16
419-423
1977
Rattus norvegicus
Kutty, R.K.; Maines, M.D.
Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver
J. Biol. Chem.
257
9944-9952
1982
Rattus norvegicus
Yoshida, T.; Kikuchi, G.
Purification and properties of heme oxygenase from pig spleen microsomes
J. Biol. Chem.
253
4224-4229
1978
Sus scrofa
Matasek, P.; Solangi, K.; Goodman, A.I.; Levere, R.D.; Chernick, R.J.; Abraham, N.G.
Properties of human kidney heme oxygenase: inhibition by synthetic heme analogues and metalloporphyrins
Biochem. Biophys. Res. Commun.
157
480-487
1988
Homo sapiens
Yoshinaga, T.; Sassa, S.; Kappas, A.
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation
J. Biol. Chem.
257
7778-7785
1982
Bos taurus
Trakshel, G.M.; Kutty, R.K.; Maines, M.D.
Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform
J. Biol. Chem.
261
11131-11137
1986
Rattus norvegicus
Cornejo, J.; Beale, S.I.
Algal heme oxygenase from Cyanidium caldarium. Partial purification and fractionation into three required protein components
J. Biol. Chem.
263
11915-11921
1988
Cyanidium caldarium
Trakshel, G.M.; Maines, M.D.
Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit
J. Biol. Chem.
264
1323-1328
1989
Oryctolagus cuniculus, Rattus norvegicus
Kutty, R.K.; Maines, M.D.
Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria
Biochem. J.
246
467-474
1987
Bos taurus
Braggins, P.E.; Trakshel, G.M.; Kutty, R.K.; Maines, M.D.
Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver
Biochem. Biophys. Res. Commun.
141
528-533
1986
Rattus norvegicus
Rosenberg, D.W.; Kappas, A.
Characterization of heme oxygenase in the small intestinal epithelium
Arch. Biochem. Biophys.
274
471-480
1989
Rattus norvegicus
Yoshinaga, T.; Sassa, S.; Kappas, A.
The oxidative degradation of heme c by the microsomal heme oxygenase system
J. Biol. Chem.
257
7803-7807
1982
Bos taurus, Rattus norvegicus
Rhie, G.E.; Beale, S.I.
Regulation of heme oxygenase activity in Cyanidium caldarium by light, glucose, and phycobilin precursors
J. Biol. Chem.
269
9620-9626
1994
Cyanidium caldarium
Ishikawa, K.; Takeuchi, N.; Takahashi, S.; Matera, K.M.; Sato, M.; Shibahara, S.; Rousseau, D.L.; Ikeda-Saito, M.; Yoshida, T.
Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2
J. Biol. Chem.
270
6345-6350
1995
Homo sapiens
Wilks, A.; Black, S.M.; Miller, W.L.; Ortiz de Montellano, P.R.
Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase
Biochemistry
34
4421-4427
1995
Homo sapiens
Wilks, A.; de Montellano, P.R.O.; Sun, J.; Loehr, T.M.
Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis
Biochemistry
35
930-936
1996
Homo sapiens
Torpey, J.; Ortiz de Montellano, P.R.
Oxidation of alpha-meso-formylmesoheme by heme oxygenase. Electronic control of the reaction regiospecificity
J. Biol. Chem.
272
22008-22014
1997
Homo sapiens
Wilks, A.; Schmitt, M.P.
Expression and characterization of a heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Iron acquisition requires oxidative cleavage of the heme macrocyle
J. Biol. Chem.
273
837-841
1998
Corynebacterium diphtheriae
Chu, G.C.; Katakura, K.; Zhang, X.; Yoshida, T.; Ikeda-Saito, M.
Heme degradation as catalyzed by a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae
J. Biol. Chem.
274
21319-21325
1999
Corynebacterium diphtheriae
Schuller, D.J.; Wilks, A.; De Montellano, P.R.O.; Poulos, T.L.
Crystal structure of human heme oxygenase-1
Nat. Struct. Biol.
6
860-867
1999
Homo sapiens
Ding, Y.; McCoubrey, W.K., Jr.; Maines, M.D.
Interaction of heme oxygenase-2 with nitric oxide donors: is the oxygenase an intracellular sink for NO?
Eur. J. Biochem.
264
854-861
1999
Rattus norvegicus
Wilks, A.; Moenne-Loccoz, P.
Identification of the proximal ligand His-20 in heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Oxidative cleavage of the heme macrocycle does not require the proximal histidine
J. Biol. Chem.
275
11686-11692
2000
Corynebacterium diphtheriae, Homo sapiens
Liu, Y.; Ortiz de Montellano, P.R.
Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme oxygenase-1
J. Biol. Chem.
275
5297-5307
2000
Homo sapiens
Zhou, H.; Migita, C.T.; Sato, M.; Sun, D.; Zhang, X.; Ikeda-Saito, M.; Fujii, H.; Yoshida, T.
Participation of Carboxylate Amino Acid Side Chain in Regiospecific Oxidation of Heme by Heme Oxygenase
J. Am. Chem. Soc.
122
8311-8312
2000
Rattus norvegicus
-
Botros, F.T.; Laniado-Schwartzmann, M.; Abraham, N.G.
Regulation of cyclooxygenase- and cytochrome P450-derived eicosanoids by heme oxygenase in the rat kidney
Hypertension
39
639-644
2002
Rattus norvegicus
Christova, T.Y.; Duridanova, D.B.; Setchenska, M.S.
Enhanced heme oxygenase activity increases the antioxidant defense capacity of guinea pig liver upon acute cobalt chloride loading: comparison with rat liver
Comp. Biochem. Physiol. C
131
177-184
2002
Cavia porcellus, Rattus norvegicus
Ryter, S.W.; Otterbein, L.E.; Morse, D.; Choi, A.M.K.
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Mol. Cell. Biochem.
234-235
249-263
2002
Mammalia, Rattus norvegicus
Sugishima, M.; Sakamoto, H.; Higashimoto, Y.; Omata, Y.; Hayashi, S.; Noguchi, M.; Fukuyama, K.
Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide. Implication for regiospecific hydroxylation of heme at the alpha-meso carbon
J. Biol. Chem.
277
45086-45090
2002
Rattus norvegicus (P06762)
Davydov, R.; Kofman, V.; Fujii, H.; Yoshida, T.; Ikeda-Saito, M.; Hoffman, B.M.
Catalytic mechanism of heme oxygenase through EPR and ENDOR of cryoreduced oxy-heme oxygenase and its Asp 140 mutants
J. Am. Chem. Soc.
124
1798-1808
2002
Rattus norvegicus
Schuller, D.J.; Zhu, W.; Stojiljkovic, I.; Wilks, A.; Poulos, T.L.
Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1
Biochemistry
40
11552-11558
2001
Neisseria meningitidis
Bruggemann, H.; Bauer, R.; Raffestin, S.; Gottschalk, G.
Characterization of a heme oxygenase of Clostridium tetani and its possible role in oxygen tolerance
Arch. Microbiol.
182
259-263
2004
Clostridium tetani
Balogun, E.; Foresti, R.; Green, C.J.; Motterlini, R.
Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells
Biochem. Biophys. Res. Commun.
308
950-955
2003
Sus scrofa
Noriega, G.O.; Balestrasse, K.B.; Batlle, A.; Tomaro, M.L.
Heme oxygenase exerts a protective role against oxidative stress in soybean leaves
Biochem. Biophys. Res. Commun.
323
1003-1008
2004
Glycine max
Zhang, X.; Fujii, H.; Matera, K.M.; Migita, C.T.; Sun, D.; Sato, M.; Ikeda-Saito, M.; Yoshida, T.
Stereoselectivity of each of the three steps of the heme oxygenase reaction: Hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin
Biochemistry
42
7418-7426
2003
Rattus norvegicus
Lad, L.; Friedman, J.; Li, H.; Bhaskar, B.; Ortiz de Montellano, P.R.; Poulos, T.L.
Crystal structure of human heme oxygenase-1 in a complex with biliverdin
Biochemistry
43
3793-3801
2004
Homo sapiens
Sugishima, M.; Hagiwara, Y.; Zhang, X.; Yoshida, T.; Migita, C.T.; Fukuyama, K.
Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme
Biochemistry
44
4257-4266
2005
Synechocystis sp.
Wagener, F.A.; van Beurden, H.E.; von den Hoff, J.W.; Adema, G.J.; Figdor, C.G.
The heme-heme oxygenase system: a molecular switch in wound healing
Blood
102
521-528
2003
Rattus norvegicus
Sugishima, M.; Migita, C.T.; Zhang, X.; Yoshida, T.; Fukuyama, K.
Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme
Eur. J. Biochem.
271
4517-4525
2004
Synechocystis sp.
Sugishima, M.; Sakamoto, H.; Higashimoto, Y.; Noguchi, M.; Fukuyama, K.
Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction
J. Biol. Chem.
278
32352-32358
2003
Rattus norvegicus (P06762)
Friedman, J.; Lad, L.; Deshmukh, R.; Li, H.; Wilks, A.; Poulos, T.L.
Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation
J. Biol. Chem.
278
34654-34659
2003
Neisseria meningitidis
Lad, L.; Schuller, D.J.; Shimizu, H.; Friedman, J.; Li, H.; Ortiz de Montellano, P.R.; Poulos, T.L.
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1
J. Biol. Chem.
278
7834-7843
2003
Homo sapiens
Hirotsu, S.; Chu, G.C.; Unno, M.; Lee, D.S.; Yoshida, T.; Park, S.Y.; Shiro, Y.; Ikeda-Saito, M.
The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae
J. Biol. Chem.
279
11937-11947
2004
Corynebacterium diphtheriae (P71119), Corynebacterium diphtheriae
Unno, M.; Matsui, T.; Chu, G.C.; Couture, M.; Yoshida, T.; Rousseau, D.L.; Olson, J.S.; Ikeda-Saito, M.
Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function
J. Biol. Chem.
279
21055-21061
2004
Corynebacterium diphtheriae (P71119), Corynebacterium diphtheriae
Boehning, D.; Sedaghat, L.; Sedlak, T.W.; Snyder, S.H.
Heme oxygenase-2 is activated by calcium-calmodulin
J. Biol. Chem.
279
30927-30930
2004
Rattus norvegicus
Wang, J.; Niemevz, F.; Lad, L.; Huang, L.; Alvarez, D.E.; Buldain, G.; Poulos, T.L.; de Montellano, P.R.
Human heme oxygenase oxidation of 5- and 15-phenylhemes
J. Biol. Chem.
279
42593-42604
2004
Homo sapiens (P09601), Homo sapiens
Wang, J.; Lad, L.; Poulos, T.L.; Ortiz de Montellano, P.R.
Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant
J. Biol. Chem.
280
2797-2806
2005
Homo sapiens (P09601), Homo sapiens
Matsui, T.; Furukawa, M.; Unno, M.; Tomita, T.; Ikeda-Saito, M.
Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO: A water-driven oxygen activation mechanism
J. Biol. Chem.
280
2981-2989
2005
Corynebacterium diphtheriae (P71119), Corynebacterium diphtheriae
Immenschuh, S.; Baumgart-Vogt, E.; Tan, M.; Iwahara, S.; Ramadori, G.; Fahimi, H.D.
Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver
J. Histochem. Cytochem.
51
1621-1631
2003
Rattus norvegicus
Lad, L.; Ortiz de Montellano, P.R.; Poulos, T.L.
Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: Catalytic implications for heme cleavage
J. Inorg. Biochem.
98
1686-1695
2004
Homo sapiens (P09601), Homo sapiens
Farhangkhoee, H.; Khan, Z.A.; Mukherjee, S.; Cukiernik, M.; Barbin, Y.P.; Karmazyn, M.; Chakrabarti, S.
Heme oxygenase in diabetes-induced oxidative stress in the heart
J. Mol. Cell. Cardiol.
35
1439-1448
2003
Rattus norvegicus
Xia, Z.W.; Zhou, W.P.; Cui, W.J.; Zhang, X.H.; Shen, Q.X.; Li, Y.Z.; Yu, S.C.
Structure prediction and activity analysis of human heme oxygenase-1 and its mutant
World J. Gastroenterol.
10
2352-2356
2004
Homo sapiens
Hsu, M.; Muchova, L.; Morioka, I.; Wong, R.J.; Schroeder, H.; Stevenson, D.K.
Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo
Biochem. Biophys. Res. Commun.
343
738-744
2006
Rattus norvegicus
Yasui, Y.; Nakamura, M.; Onda, T.; Uehara, T.; Murata, S.; Matsui, N.; Fukuishi, N.; Akagi, R.; Suematsu, M.; Akagi, M.
Heme oxygenase-1 inhibits cytokine production by activated mast cells
Biochem. Biophys. Res. Commun.
354
485-490
2007
Rattus norvegicus, Rattus norvegicus (P06762)
Liu, Y.; Ma, L.H.; Zhang, X.; Yoshida, T.; Satterlee, J.D.; La Mar, G.N.
Characterization of the spontaneous "aging" of the heme oxygenase from the pathological bacterium Neisseria meningitidis via cleavage of the C-terminus in contact with the substrate. Implications for functional studies and the crystal structure
Biochemistry
45
3875-3886
2006
Neisseria meningitidis
Wang, J.; Evans, J.P.; Ogura, H.; La Mar, G.N.; Ortiz de Montellano, P.R.
Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network
Biochemistry
45
61-73
2006
Homo sapiens (P09601), Homo sapiens
Sugishima, M.; Higashimoto, Y.; Oishi, T.; Takahashi, H.; Sakamoto, H.; Noguchi, M.; Fukuyama, K.
X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase
Biochemistry
46
1860-1867
2007
Rattus norvegicus (P06762)
Roman, G.; Riley, J.G.; Vlahakis, J.Z.; Kinobe, R.T.; Brien, J.F.; Nakatsu, K.; Szarek, W.A.
Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring
Bioorg. Med. Chem.
15
3225-3234
2007
Rattus norvegicus
Hu, H.B.; Wang, W.; Han, L.; Zhou, W.P.; Zhang, X.H.
An improved method for purification of recombinant truncated heme oxygenase-1 by expanded bed adsorption and gel filtration
Bioprocess Biosyst. Eng.
30
87-90
2007
Homo sapiens
Han, Y.; Platonov, A.G.; Akhalaia, M.I.a.; Akhalaia, M.Y.; Song, J.Y.; Ahn, J.Y.; Yun, Y.S.
Tissue-specific changes in heme oxygenase activity and level of nonprotein thiols in C57Bl/6 mice after whole-body gamma-irradiation
Bull. Exp. Biol. Med.
140
341-344
2005
Mus musculus
McDaid, J.; Yamashita, K.; Chora, A.; Ollinger, R.; Strom, T.B.; Li, X.C.; Bach, F.H.; Soares, M.P.
Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
FASEB J.
19
458-480
2005
Mus musculus
Gohya, T.; Zhang, X.; Yoshida, T.; Migita, C.T.
Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean)--coordination structure of the heme complex and catabolism of heme
FEBS J.
273
5384-5399
2006
Glycine max
Hirai, K.; Sasahira, T.; Ohmori, H.; Fujii, K.; Kuniyasu, H.
Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice
Int. J. Cancer
120
500-505
2007
Mus musculus
Kawakami, T.; Takahashi, T.; Shimizu, H.; Nakahira, K.; Takeuchi, M.; Katayama, H.; Yokoyama, M.; Morita, K.; Akagi, R.; Sassa, S.
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity
Int. J. Mol. Med.
18
537-546
2006
Rattus norvegicus
Liu, Y.; Zhang, X.; Yoshida, T.; La Mar, G.N.
Solution 1H NMR characterization of the distal H-bond network and the effective axial field in the resting-state, high-spin ferric, substrate-bound complex of heme oxygenase from N. meningitidis
J. Am. Chem. Soc.
127
6409-6422
2005
Neisseria meningitidis
Ma, L.H.; Liu, Y.; Zhang, X.; Yoshida, T.; Langry, K.C.; Smith, K.M.; La Mar, G.N.
Modulation of the axial water hydrogen-bonding properties by chemical modification of the substrate in resting state, substrate-bound heme oxygenase from Neisseria meningitidis; coupling to the distal H-bond network via ordered water molecules
J. Am. Chem. Soc.
128
6391-6399
2006
Neisseria meningitidis
Suits, M.D.; Jaffer, N.; Jia, Z.
Structure of the Escherichia coli O157:H7 heme oxygenase ChuS in complex with heme and enzymatic inactivation by mutation of the heme coordinating residue His-193
J. Biol. Chem.
281
36776-36782
2006
Escherichia coli
Lad, L.; Koshkin, A.; de Montellano, P.R.; Poulos, T.L.
Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity
J. Biol. Inorg. Chem.
10
138-146
2005
Homo sapiens (P09601), Homo sapiens
Vlahakis, J.Z.; Kinobe, R.T.; Bowers, R.J.; Brien, J.F.; Nakatsu, K.; Szarek, W.A.
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors
J. Med. Chem.
49
4437-4441
2006
Homo sapiens, Rattus norvegicus
Yannarelli, G.G.; Noriega, G.O.; Batlle, A.; Tomaro, M.L.
Heme oxygenase up-regulation in ultraviolet-B irradiated soybean plants involves reactive oxygen species
Planta
224
1154-1162
2006
Glycine max (Q94FX1), Glycine max
Furci, L.M.; Lopes, P.; Eakanunkul, S.; Zhong, S.; MacKerell, A.D.; Wilks, A.
Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets
J. Med. Chem.
50
3804-3813
2007
Neisseria meningitidis
Mingone, C.J.; Ahmad, M.; Gupte, S.A.; Chow, J.L.; Wolin, M.S.
Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide
Am. J. Physiol. Heart Circ. Physiol.
294
H1244-H1250
2008
Bos taurus (Q5E9F2), Bos taurus
Muz, B.; Kontny, E.; Marcinkiewicz, J.; Maslinski, W.
Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine
Amino Acids
35
397-402
2008
Homo sapiens (P09601)
Joung, E.J.; Li, M.H.; Lee, H.G.; Somparn, N.; Jung, Y.S.; Na, H.K.; Kim, S.H.; Cha, Y.N.; Surh, Y.J.
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target
Antioxid. Redox Signal.
9
2087-2098
2007
Homo sapiens (P09601)
Kroenke, G.; Kadl, A.; Ikonomu, E.; Blueml, S.; Fuernkranz, A.; Sarembock, I.J.; Bochkov, V.N.; Exner, M.; Binder, B.R.; Leitinger, N.
Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors
Arterioscler. Thromb. Vasc. Biol.
27
1276-1282
2007
Homo sapiens (P09601), Homo sapiens
Lin, C.C.; Liu, X.M.; Peyton, K.; Wang, H.; Yang, W.C.; Lin, S.J.; Durante, W.
Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1
Arterioscler. Thromb. Vasc. Biol.
28
739-745
2008
Homo sapiens (P09601), Homo sapiens
Pae, H.O.; Jeong, S.O.; Koo, B.S.; Ha, H.Y.; Lee, K.M.; Chung, H.T.
Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages
Biochem. Biophys. Res. Commun.
371
361-365
2008
Mus musculus (P14901)
Ogborne, R.M.; Rushworth, S.A.; OConnell, M.A.
Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2
Biochem. Biophys. Res. Commun.
373
584-588
2008
Homo sapiens (P09601)
Huber, W.J.; Backes, W.L.
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
Biochemistry
46
12212-12219
2007
Homo sapiens (P09601), Homo sapiens
Iyer, A.K.; Greish, K.; Fang, J.; Murakami, R.; Maeda, H.
High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor
Biomaterials
28
1871-1881
2007
Homo sapiens (P09601), Homo sapiens
Kim, K.M.; Pae, H.O.; Zhung, M.; Ha, H.Y.; Ha, Y.A.; Chai, K.Y.; Cheong, Y.K.; Kim, J.M.; Chung, H.T.
Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages
Biomed. Pharmacother.
62
630-636
2008
Mus musculus (P14901)
Nowis, D.; Bugajski, M.; Winiarska, M.; Bil, J.; Szokalska, A.; Salwa, P.; Issat, T.; Was, H.; Jozkowicz, A.; Dulak, J.; Stoklosa, T.; Golab, J.
Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
BMC Cancer
8
197
2008
Homo sapiens (P09601), Homo sapiens, Mus musculus (P14901), Mus musculus
Kinobe, R.T.; Dercho, R.A.; Nakatsu, K.
Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic?
Can. J. Physiol. Pharmacol.
86
577-599
2008
Mus musculus (O70252), Mus musculus (P14901), Homo sapiens (P09601), Homo sapiens (P30519)
Liu, X.M.; Azam, M.A.; Peyton, K.J.; Ensenat, D.; Keswani, A.N.; Wang, H.; Durante, W.
Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries
Cardiovasc. Res.
74
169-179
2007
Rattus norvegicus (P06762)
Wen, F.; Brown, K.E.; Britigan, B.E.; Schmidt, W.N.
Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity
Cell Biol. Toxicol.
24
175-188
2008
Homo sapiens (P09601), Homo sapiens
Li, H.Y.; Zhong, Y.F.; Wu, S.Y.; Shi, N.
NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells
Chem. Res. Toxicol.
20
1242-1251
2007
Rattus norvegicus (P06762)
Sawle, P.; Moulton, B.E.; Jarzykowska, M.; Green, C.J.; Foresti, R.; Fairlamb, I.J.; Motterlini, R.
Structure-activity relationships of methoxychalcones as inducers of heme oxygenase-1
Chem. Res. Toxicol.
21
1484-1494
2008
Mus musculus (P14901)
Kim, K.M.; Pae, H.O.; Zheng, M.; Park, R.; Kim, Y.M.; Chung, H.T.
Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress
Circ. Res.
101
919-927
2007
Homo sapiens (P09601), Homo sapiens
Chen-Roetling, J.; Li, Z.; Regan, R.F.
Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity
Curr. Neurovasc. Res.
5
193-198
2008
Mus musculus
Jeong, G.S.; Pae, H.O.; Jeong, S.O.; Kim, Y.C.; Kwon, T.O.; Lee, H.S.; Kim, N.S.; Park, S.D.; Chung, H.T.
The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells
Eur. J. Pharmacol.
565
37-44
2007
Homo sapiens (P09601)
Horvath, K.; Varga, C.; Berko, A.; Posa, A.; Laszlo, F.; Whittle, B.J.
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis
Eur. J. Pharmacol.
581
315-323
2008
Rattus norvegicus (P06762)
Pae, H.O.; Jeong, G.S.; Jeong, S.O.; Kim, H.S.; Kim, S.A.; Kim, Y.C.; Yoo, S.J.; Kim, H.D.; Chung, H.T.
Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
Exp. Mol. Med.
39
267-277
2007
Rattus norvegicus (P06762), Homo sapiens (P09601), Homo sapiens
Kang, K.A.; Lee, K.H.; Park, J.W.; Lee, N.H.; Na, H.K.; Surh, Y.J.; You, H.J.; Chung, M.H.; Hyun, J.W.
Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor
FEBS Lett.
581
2000-2008
2007
Cricetulus griseus
Lin, Q.S.; Weis, S.; Yang, G.; Zhuang, T.; Abate, A.; Dennery, P.A.
Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress
Free Radic. Biol. Med.
44
847-855
2008
Rattus norvegicus (P06762)
Chen, N.; Shao, W.; Lv, P.; Zhang, S.; Chen, Y.; Zhu, L.; Lu, Y.; Shen, Y.
Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells
Free Radic. Res.
41
990-996
2007
Homo sapiens (P09601), Homo sapiens
Gong, Q.; Yin, H.; Fang, M.; Xiang, Y.; Yuan, C.L.; Zheng, G.Y.; Yang, H.; Xiong, P.; Chen, G.; Gong, F.L.; Zheng, F.
Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice
Int. Immunopharmacol.
8
792-798
2008
Mus musculus (P14901)
Sass, G.; Leukel, P.; Schmitz, V.; Raskopf, E.; Ocker, M.; Neureiter, D.; Meissnitzer, M.; Tasika, E.; Tannapfel, A.; Tiegs, G.
Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice
Int. J. Cancer
123
1269-1277
2008
Mus musculus (P14901), Mus musculus, Mus musculus C3H/HEN (P14901)
Frank, J.; Lornejad-Schaefer, M.R.; Schoeffl, H.; Flaccus, A.; Lambert, C.; Biesalski, H.K.
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy
Int. J. Oncol.
31
1539-1545
2007
Homo sapiens (P09601)
Gruber, F.; Oskolkova, O.; Leitner, A.; Mildner, M.; Mlitz, V.; Lengauer, B.; Kadl, A.; Mrass, P.; Kroenke, G.; Binder, B.R.; Bochkov, V.N.; Leitinger, N.; Tschachler, E.
Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells
J. Biol. Chem.
282
16934-16941
2007
Homo sapiens (P09601)
Lin, Q.; Weis, S.; Yang, G.; Weng, Y.H.; Helston, R.; Rish, K.; Smith, A.; Bordner, J.; Polte, T.; Gaunitz, F.; Dennery, P.A.
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
J. Biol. Chem.
282
20621-20633
2007
Mus musculus, Rattus norvegicus (P06762)
Lee, G.H.; Kim, H.K.; Chae, S.W.; Kim, D.S.; Ha, K.C.; Cuddy, M.; Kress, C.; Reed, J.C.; Kim, H.R.; Chae, H.J.
Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression
J. Biol. Chem.
282
21618-21628
2007
Homo sapiens (P09601)
Bianchetti, C.M.; Yi, L.; Ragsdale, S.W.; Phillips, G.N.
Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2
J. Biol. Chem.
282
37624-37631
2007
Homo sapiens (P30519), Homo sapiens
Koizumi, S.; Gong, P.; Suzuki, K.; Murata, M.
Cadmium-responsive element of the human heme oxygenase-1 gene mediates heat shock factor 1-dependent transcriptional activation
J. Biol. Chem.
282
8715-8723
2007
Homo sapiens
Grion, N.; Repetto, E.M.; Pomeraniec, Y.; Calejman, C.M.; Astort, F.; Sanchez, R.; Pignataro, O.P.; Arias, P.; Cymeryng, C.B.
Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production
J. Endocrinol.
194
11-20
2007
Rattus norvegicus
Kim, B.C.; Jeon, W.K.; Hong, H.Y.; Jeon, K.B.; Hahn, J.H.; Kim, Y.M.; Numazawa, S.; Yosida, T.; Park, E.H.; Lim, C.J.
The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1
J. Ethnopharmacol.
113
240-247
2007
Mus musculus (P14901)
Hagiya, Y.; Adachi, T.; Ogura, S.; An, R.; Tamura, A.; Nakagawa, H.; Okura, I.; Mochizuki, T.; Ishikawa, T.
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
J. Exp. Ther. Oncol.
7
153-167
2008
Homo sapiens (P09601), Homo sapiens
Li, X.; Schwacha, M.G.; Chaudry, I.H.; Choudhry, M.A.
Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2-production in a two-hit model of alcohol intoxication and burn injury
J. Immunol.
180
6933-6940
2008
Rattus norvegicus (P06762)
Mashreghi, M.F.; Klemz, R.; Knosalla, I.S.; Gerstmayer, B.; Janssen, U.; Buelow, R.; Jozkowicz, A.; Dulak, J.; Volk, H.D.; Kotsch, K.
Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3
J. Immunol.
180
7919-7930
2008
Mus musculus (P14901), Mus musculus, Mus musculus C57BL/6 (P14901)
Naidu, S.; Wijayanti, N.; Santoso, S.; Kietzmann, T.; Immenschuh, S.
An atypical NF-kappaB-regulated pathway mediates phorbol ester-dependent heme oxygenase-1 gene activation in monocytes
J. Immunol.
181
4113-4123
2008
Mus musculus (P14901), Rattus norvegicus (P06762)
Lee, S.; Li, R.; Kim, B.; Palvolgyi, R.; Ho, T.; Yang, Q.Z.; Xu, J.; Szeto, W.L.; Honda, H.; Berliner, J.A.
Ox-PAPC activation of plasma membrane electron transport (PMET) system increases expression of heme oxygenase 1 (HO-1) in human aortic endothelial cell (HAEC)
J. Lipid Res.
50
265-274
2008
Homo sapiens (P09601), Homo sapiens
Egea, J.; Rosa, A.O.; Cuadrado, A.; Garcia, A.G.; Lopez, M.G.
Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress
J. Neurochem.
102
1842-1852
2007
Bos taurus (Q5E9F2), Bos taurus
Chen, M.; Regan, R.F.
Time course of increased heme oxygenase activity and expression after experimental intracerebral hemorrhage: correlation with oxidative injury
J. Neurochem.
103
2015-2021
2007
Mus musculus (P14901), Mus musculus
Kivelae, A.M.; Kansanen, E.; Jyrkkaenen, H.K.; Nurmi, T.; Ylae-Herttuala, S.; Levonen, A.L.
Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells
J. Nutr.
138
1263-1268
2008
Homo sapiens (P09601), Homo sapiens
Aziz, M.T.A.; Mostafa, T.; Atta, H.; Rashed, L.; Marzouk, S.A.; Obaia, E.M.; Sabry, D.; Hassouna, A.A.; El-Shehaby, A.M.; Aziz, A.T.
The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues
J. Sex Med.
5
1636-1645
2008
Rattus norvegicus
Jin, Y.C.; Gam, S.C.; Jung, J.H.; Hyun, J.S.; Chang, K.C.; Hyun, J.S.
Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues
J. Sex Med.
5
1876-1882
2008
Rattus norvegicus (P06762)
Eipel, C.; Eisold, M.; Schuett, H.; Vollmar, B.
Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers
J. Surg. Res.
139
113-120
2007
Rattus norvegicus (P06762)
Chung, H.T.; Choi, B.M.; Kwon, Y.G.; Kim, Y.M.
Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation
Methods Enzymol.
441
329-338
2008
Homo sapiens (P09601)
Chen, T.H.; Hsu, Y.T.; Chen, C.H.; Kao, S.H.; Lee, H.M.
Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells
Mitochondrion
7
101-105
2007
Mus musculus (P14901)
Lin, C.W.; Shen, S.C.; Hou, W.C.; Yang, L.Y.; Chen, Y.C.
Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9
Mol. Cancer Ther.
7
1195-1206
2008
Homo sapiens (P09601), Homo sapiens
Hartung, R.; Parapuram, S.K.; Ganti, R.; Hunt, D.M.; Chalam, K.V.; Hunt, R.C.
Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells
Mol. Vis.
13
66-78
2007
Homo sapiens (P09601), Homo sapiens
Park, C.; Cho, I.H.; Kim, D.; Jo, E.K.; Choi, S.Y.; Oh, S.B.; Park, K.; Kim, J.S.; Lee, S.J.
Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury
Neurosci. Lett.
431
123-128
2008
Mus musculus (P14901), Mus musculus, Mus musculus C57BL/6 (P14901)
Mores, N.; Errico, S.; Pusateri, A.; Barone, E.; Mancuso, C.
Heme oxygenase expression and activity in immortalized hypothalamic neurons GT1-7
Neurosci. Lett.
444
106-108
2008
Mus musculus
Reichard, J.F.; Motz, G.T.; Puga, A.
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1
Nucleic Acids Res.
35
7074-7086
2007
Homo sapiens (P09601)
Li, X.Y.; Zhang, C.; Wang, S.F.; Ji, Y.L.; Wang, H.; Zhao, L.; Xu, D.X.
Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species
Toxicol. Lett.
176
169-177
2008
Mus musculus (P14901), Mus musculus
Chow, J.M.; Huang, G.C.; Lin, H.Y.; Shen, S.C.; Yang, L.Y.; Chen, Y.C.
Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1
Toxicol. Lett.
177
97-107
2008
Homo sapiens (P09601), Rattus norvegicus (P06762)
Hsieh, C.H.; Jeng, S.F.; Hsieh, M.W.; Chen, Y.C.; Rau, C.S.; Lu, T.H.; Chen, S.S.
Statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide
Toxicol. Sci.
102
150-159
2008
Rattus norvegicus (P06762), Mus musculus (P14901)
Li Volti, G.; Sorrenti, V.; Murabito, P.; Galvano, F.; Veroux, M.; Gullo, A.; Acquaviva, R.; Stacchiotti, A.; Bonomini, F.; Vanella, L.; Di Giacomo, C.
Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury
Transplant. Proc.
39
2986-2991
2007
Rattus norvegicus (P06762)
Huber III, W.; Backes, W.
Quantitation of heme oxygenase 1: Heme titration increases yield of purified protein
Anal. Biochem.
373
167-169
2008
Homo sapiens
Abdel Aziz, M.T.; Mostafa, T.; Roshdy, N.; Hosni, H.; Rashed, L.; Sabry, D.; Abdel Nasser, T.; Abdel Azim, O.; Abdel Gawad, O.
Heme oxygenase enzyme activity in human seminal plasma of fertile and infertile males
Andrologia
40
292-297
2008
Homo sapiens
Gisk, B.; Yasui, Y.; Kohchi, T.; Frankenberg-Dinkel, N.
Characterization of the heme oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions
Biochem. J.
425
425-434
2010
Arabidopsis thaliana
Peng, D.; Ogura, H.; Zhu, W.; Ma, L.H.; Evans, J.P.; Ortiz de Montellano, P.R.; La Mar, G.N.
Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase
Biochemistry
48
11231-11242
2009
Homo sapiens
Ogura, H.; Evans, J.P.; Peng, D.; Satterlee, J.D.; Ortiz de Montellano, P.R.; La Mar, G.N.
The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism
Biochemistry
48
3127-3137
2009
Homo sapiens
Badyal, S.K.; Eaton, G.; Mistry, S.; Pipirou, Z.; Basran, J.; Metcalfe, C.L.; Gumiero, A.; Handa, S.; Moody, P.C.; Raven, E.L.
Evidence for heme oxygenase activity in a heme peroxidase
Biochemistry
48
4738-4746
2009
Homo sapiens (P09601)
Evans, J.P.; Kandel, S.; Ortiz de Montellano, P.R.
Isocyanides inhibit human heme oxygenases at the verdoheme stage
Biochemistry
48
8920-8928
2009
Candida albicans, Homo sapiens
Vlahakis, J.Z.; Hum, M.; Rahman, M.N.; Jia, Z.; Nakatsu, K.; Szarek, W.A.
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring
Bioorg. Med. Chem.
17
2461-2475
2009
Rattus norvegicus
Huber, W.J.; Marohnic, C.C.; Peters, M.; Alam, J.; Reed, J.R.; Masters, B.S.; Backes, W.L.
Measurement of membrane-bound human heme oxygenase-1 activity using a chemically defined assay system
Drug Metab. Dispos.
37
857-864
2009
Homo sapiens
Bilban, M.; Haslinger, P.; Prast, J.; Klinglmueller, F.; Woelfel, T.; Haider, S.; Sachs, A.; Otterbein, L.E.; Desoye, G.; Hiden, U.; Wagner, O.; Knoefler, M.
Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma
Endocrinology
150
1000-1013
2009
Homo sapiens
Zheng, J.; Tian, Q.; Hou, W.; Watts, J.A.; Schrum, L.W.; Bonkovsky, H.L.
Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol
FEBS Lett.
582
1829-1834
2008
Rattus norvegicus
Zhou, W.P.; Zhong, W.W.; Zhang, X.H.; Ding, J.P.; Zhang, Z.L.; Xia, Z.W.
Comparison of the crystal structure and function to wild-type and His25Ala mutant human heme oxygenase-1
Int. J. Mol. Med.
23
379-387
2009
Homo sapiens
Nakao, A.; Kaczorowski, D.J.; Sugimoto, R.; Billiar, T.R.; McCurry, K.R.
Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury
J. Clin. Biochem. Nutr.
42
78-88
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Andersen, M.H.; Sorensen, R.B.; Brimnes, M.K.; Svane, I.M.; Becker, J.C.; thor Straten, P.
Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients
J. Clin. Invest.
119
2245-2256
2009
Homo sapiens
Hu, C.M.; Liu, Y.H.; Cheah, K.P.; Li, J.S.; Lam, C.S.; Yu, W.Y.; Choy, C.S.
Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide
J. Ethnopharmacol.
121
79-85
2009
Mus musculus
Rahman, M.N.; Vlahakis, J.Z.; Roman, G.; Vukomanovic, D.; Szarek, W.A.; Nakatsu, K.; Jia, Z.
Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors
J. Inorg. Biochem.
104
324-330
2010
Rattus norvegicus (P06762), Rattus norvegicus (P23711), Homo sapiens (P09601), Homo sapiens
Rahman, M.N.; Vlahakis, J.Z.; Szarek, W.A.; Nakatsu, K.; Jia, Z.
X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors
J. Med. Chem.
51
5943-5952
2008
Homo sapiens (P09601), Homo sapiens
Weis, N.; Weigert, A.; von Knethen, A.; Bruene, B.
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants
Mol. Biol. Cell
20
1280-1288
2009
Homo sapiens
Chen-Roetling, J.; Li, Z.; Chen, M.; Awe, O.O.; Regan, R.F.
Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway
Neuropharmacology
56
922-928
2009
Mus musculus
Nath, K.A.; Hernandez, M.C.; Croatt, A.J.; Katusic, Z.S.; Juncos, L.A.
Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II
Am. J. Physiol. Regul. Integr. Comp. Physiol.
299
R1183-R1191
2010
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Ishikado, A.; Nishio, Y.; Morino, K.; Ugi, S.; Kondo, H.; Makino, T.; Kashiwagi, A.; Maegawa, H.
Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells
Biochem. Biophys. Res. Commun.
402
99-104
2010
Homo sapiens
Gisk, B.; Bregier, F.; Krueger, R.A.; Broering, M.; Frankenberg-Dinkel, N.
Enzymatic ring opening of an iron corrole by plant-type heme oxygenases: unexpected substrate and protein selectivities
Biochemistry
49
10042-10044
2010
Synechocystis sp., Arabidopsis thaliana
Roman, G.; Rahman, M.; Vukomanovic, D.; Jia, Z.; Nakatsu, K.; Szarek, W.
Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone
Chem. Biol. Drug Des.
75
68-90
2010
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Park, S.Y.; Kim, Y.H.; Kim, E.K.; Ryu, E.Y.; Lee, S.J.
Heme oxygenase-1 signals are involved in preferential inhibition of pro-inflammatory cytokine release by surfactin in cells activated with Porphyromonas gingivalis lipopolysaccharide
Chem. Biol. Interact.
188
437-445
2010
Homo sapiens
Matsui, T.; Iwasaki, M.; Sugiyama, R.; Unno, M.; Ikeda-Saito, M.
Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase
Inorg. Chem.
49
3602-3609
2010
Corynebacterium diphtheriae, Homo sapiens, Rattus norvegicus (P06762)
Lai, W.; Chen, H.; Matsui, T.; Omori, K.; Unno, M.; Ikeda-Saito, M.; Shaik, S.
Enzymatic ring-opening mechanism of verdoheme by the heme oxygenase: a combined X-ray crystallography and QM/MM study
J. Am. Chem. Soc.
132
12960-12970
2010
Corynebacterium diphtheriae (Q54AI1), Corynebacterium diphtheriae
Hu, Y.; Jiang, F.; Guo, Y.; Shen, X.; Zhang, Y.; Zhang, R.; Guo, G.; Mao, X.; Zou, Q.; Wang, D.C.
Crystal structure of HugZ, a novel heme oxygenase from Helicobacter pylori
J. Biol. Chem.
286
1537-1544
2011
Helicobacter pylori
Piantadosi, C.A.; Withers, C.M.; Bartz, R.R.; Macgarvey, N.C.; Fu, P.; Sweeney, T.E.; Welty-Wolf, K.E.; Suliman, H.B.
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
J. Biol. Chem.
286
16374-16385
2011
Mus musculus, Mus musculus C57/BL6
Lin, H.H.; Lai, S.C.; Chau, L.Y.
Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1
J. Biol. Chem.
286
3829-3838
2011
Homo sapiens
Gardner, J.D.; Yi, L.; Ragsdale, S.W.; Brunold, T.C.
Spectroscopic insights into axial ligation and active-site H-bonding in substrate-bound human heme oxygenase-2
J. Biol. Inorg. Chem.
15
1117-1127
2010
Homo sapiens
Jin, Q.; Yuan, X.; Cui, W.; Han, B.; Feng, J.; Xu, S.; Shen, W.
Isolation and characterization of a heme oxygenase-1 gene from Chinese cabbage
Mol. Biotechnol.
50
8-17
2012
Brassica rapa subsp. pekinensis (H8XZ68), Brassica rapa subsp. pekinensis
Fu, G.Q.; Xu, S.; Xie, Y.J.; Han, B.; Nie, L.; Shen, W.B.; Wang, R.
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Influence of substrate modification and C-terminal truncation on the active site structure of substrate-bound heme oxygenase from Neisseriae meningitidis. A 1H NMR study
Biochemistry
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Neisseria meningitidis
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Biochemistry
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Neisseria meningitidis
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Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): exploration of the effects of substituents at the N-1 position
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Rattus norvegicus (P23711), Rattus norvegicus Sprague-Dawley (P23711)
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Evaluation of imidazole-based compounds as heme oxygenase-1 inhibitors
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Homo sapiens (P09601), Homo sapiens (P30519), Homo sapiens
Rousset, F.; Nguyen, M.V.; Grange, L.; Morel, F.; Lardy, B.
Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes
PLoS ONE
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Homo sapiens (P09601), Homo sapiens
Lee, P.J.; Shin, I.; Seo, S.Y.; Kim, H.; Kim, H.P.
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Homo sapiens
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Structure-activity relationships of 1,2-disubstituted benzimidazoles: selective inhibition of heme oxygenase-2 activity
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Rattus norvegicus
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Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice
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Mus musculus
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Homo sapiens, Mus musculus
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Mus musculus
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Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation
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Homo sapiens
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Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease
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Homo sapiens
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Noguchi, M.; Yoshida, T.; Kikuchi, G.
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Homo sapiens (P09601), Homo sapiens (P30519)
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The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease Its time for reconciliation
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Homo sapiens
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Cloning and characterization of a heme oxygenase-2 gene from rice (Oryza sativa L.), and its expression analysis in response to some abiotic stresses
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Oryza sativa (U3PTC5)
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Sigala, P.A.; Morante, K.; Tsumoto, K.; Caaveiro, J.M.; Goldberg, D.E.
In-cell enzymology to probe His-heme ligation in heme oxygenase catalysis
Biochemistry
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Homo sapiens (P09601), Homo sapiens, Synechocystis sp. PCC 6803 (P72849)
Davydov, R.; Fleischhacker, A.S.; Bagai, I.; Hoffman, B.M.; Ragsdale, S.W.
Comparison of the mechanisms of heme hydroxylation by heme oxygenases-1 and -2 Kinetic and cryoreduction studies
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Homo sapiens (P30519), Homo sapiens
Hettiarachchi, N.; Dallas, M.; Al-Owais, M.; Griffiths, H.; Hooper, N.; Scragg, J.; Boyle, J.; Peers, C.
Heme oxygenase-1 protects against Alzheimers amyloid-beta(1-42)-induced toxicity via carbon monoxide production
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Rattus norvegicus (P06762), Homo sapiens (P09601)
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Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication
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Sus scrofa (P32394), Sus scrofa
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Iminoguanidines as allosteric inhibitors of the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa
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Pseudomonas aeruginosa (O69002), Pseudomonas aeruginosa
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Ectopic over-expression of BoHO1, a cabbage heme oxygenase gene, improved salt tolerance in Arabidopsis A case study on proteomic analysis
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Brassica oleracea
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Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism
PLoS ONE
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Leptospira interrogans serovar Icterohaemorrhagiae, Leptospira interrogans serovar Icterohaemorrhagiae serovar Lai 56601
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Human heme oxygenase 1 is a potential host cell factor against dengue virus replication
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Homo sapiens (Q96DI8), Homo sapiens
Holowiecki, A.; OShields, B.; Jenny, M.J.
Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio) Basal expression and response to pro-oxidant exposures
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