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Disease on EC 1.14.14.17 - squalene monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer.
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer.
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.
Carcinogenesis
Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells.
Carcinoma
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling.
Carcinoma, Hepatocellular
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC.
Regulation of squalene epoxidase in HepG2 cells.
Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells.
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.
Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells.
Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.
Carcinoma, Squamous Cell
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling.
Chagas Disease
Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action.
Cholelithiasis
Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse.
Colorectal Neoplasms
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis.
Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
Demyelinating Diseases
Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls.
Primary demyelination induced by exposure to tellurium alters mRNA levels for nerve growth factor receptor, SCIP, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteolipid protein in rat sciatic nerve.
Role of organotellurium species in tellurium neuropathy.
Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis.
Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression.
Dermatitis
Squalene epoxidase as hypocholesterolemic drug target revisited.
Dermatomycoses
In Silico Analog Design for Terbinafine Against Trichophyton rubrum: A Preliminary Study.
Potential anti-alopecia constituents from Theobroma cacao: An in silico study.
Gallstones
Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse.
Hypercholesterolemia
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells.
Squalene monooxygenase - a target for hypercholesterolemic therapy.
Hypersensitivity
Identification of the Arabidopsis dry2/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species.
Squalene epoxidase as a target for manipulation of squalene levels in the yeast Saccharomyces cerevisiae.
Infections
The Emerging Terbinafine-Resistant Trichophyton Epidemic: What Is the Role of Antifungal Susceptibility Testing?
Lymphoma
Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Lymphoma, Large-Cell, Anaplastic
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Muscular Diseases
Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts.
Mycoses
Genome-wide expression profiling of the response to terbinafine in Candida albicans using a cDNA microarray analysis.
The efficacy and safety of terbinafine in children.
Neoplasm Metastasis
Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis.
Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling.
Neoplasms
Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
Cholesterol Metabolism and Prostate Cancer Lethality.
Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissues.
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC.
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Squalene epoxidase as a promising metabolic target in cancer treatment.
Sterol synthesis pathway inhibition as a target for cancer treatment.
The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.
The shape of human squalene epoxidase expands the arsenal against cancer.
Neuroendocrine Tumors
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Non-alcoholic Fatty Liver Disease
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC.
Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target.
Onychomycosis
Drug Sensitivity Profile of Fungi Isolated from Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton mentagrophytes Species.
Prostatic Neoplasms
Cholesterol uptake and regulation in high-grade and lethal prostate cancers.
Squamous Cell Carcinoma of Head and Neck
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma.
Tinea
Checkerboard Analysis To Evaluate Synergistic Combinations of Existing Antifungal Drugs and Propylene Glycol Monocaprylate in Isolates from Recalcitrant Tinea Corporis and Cruris Patients Harboring Squalene Epoxidase Gene Mutation.
[Terbinafine-resistant dermatophytoses and onychomycosis due to Trichophyton rubrum].
Tooth Wear
Proteomic profile of the acquired enamel pellicle of professional wine tasters with erosive tooth wear.