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Information on EC 1.14.14.150 - costunolide synthase

for references in articles please use BRENDA:EC1.14.14.150

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IUBMB Comments

A cytochrome P-450 (heme-thiolate) protein from chicory plants. The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6α-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which spontaneously cyclises to form the lactone ring.

The enzyme appears in viruses and cellular organisms

Synonyms
costunolide synthase, cyp71bl1, (+)-costunolide synthase, cyp71bl3, cyp71bl2, cyp71bl5, cyp71bl9, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = (+)-costunolide + H2O
show the reaction diagram
(1b), spontaneous
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
overall reaction
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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