Reference on EC 1.14.14.139 - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jahan, A.; Chiang, J.Y.
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene
Am. J. Physiol.
288
G685-695
2005
Homo sapiens
Yang, Y.; Eggertsen, G.; Gafvels, M.; Andersson, U.; Einarsson, C.; Bjorkhem, I.; Chiang, J.Y.
Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1)
Biochem. Biophys. Res. Commun.
320
1204-1210
2004
Mus musculus, Rattus norvegicus
Andersson, U.; Eggertsen, G.; Bjorkhem, I.
Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity
Biochim. Biophys. Acta
1389
150-154
1998
Oryctolagus cuniculus
Andersson, U.; Yang, Y.Z.; Bjorkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene
Biochim. Biophys. Acta
1438
167-174
1999
Rattus norvegicus
Yang, Y.; Zhang, M.; Eggertsen, G.; Chiang, J.Y.
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha
Biochim. Biophys. Acta
1583
63-73
2002
Rattus norvegicus
Lundell, K.; Wikvall, K.
Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)
Biochim. Biophys. Acta
1634
86-96
2003
Sus scrofa
Kimura, K.; Ogura, M.
Effect of streptozotocin-induced diabetes on the activity of 7alpha-hydroxy-4-cholesten-3-one-specific 12alpha-hydroxylase in rats
Biol. Chem. Hoppe-Seyler
369
1117-1120
1988
Rattus norvegicus
Vlahcevic, Z.R.; Eggertsen, G.; Bjorkhem, I.; Hylemon, P.B.; Redford, K.; Pandak, W.M.
Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat
Gastroenterology
118
599-607
2000
Rattus norvegicus
Wang, J.; Greene, S.; Eriksson, L.C.; Rozell, B.; Reihner, E.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Human sterol 12alpha-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern
Histochem. Cell Biol.
123
441-446
2005
Homo sapiens
Hansson, R.; Wikvall, K.
Hydroxylations in biosynthesis and metabolism of bile acids. Catalytic properties of different cytochrome P-450
J. Biol. Chem.
255
1643-1649
1980
Oryctolagus cuniculus
Murakami, K.; Okada, Y.; Okuda, K.
Purification and characterization of 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase
J. Biol. Chem.
257
8030-8035
1982
Oryctolagus cuniculus
Ishida, H.; Noshiro, M.; Okuda, K.; Coon, M.J.
Purification and characterization of 7alpha-hydroxy-4-cholesten-3-one 12alpha-hydroxylase
J. Biol. Chem.
267
21319-21323
1992
Oryctolagus cuniculus
Eggertsen, G.; Olin, M.; Andersson, U.; Ishida, H.; Kubota, S.; Hellman, U.; Okuda, K.I.; Bjorkhem, I.
Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase
J. Biol. Chem.
271
32269-32275
1996
Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
del Castillo-Olivares, A.; Gil, G.
alpha1-Fetoprotein transcription factor is required for the expression of sterol 12alpha-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription
J. Biol. Chem.
275
17793-17799
2000
Rattus norvegicus
Zhang, M.; Chiang, J.Y.
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression
J. Biol. Chem.
276
41690-41699
2001
Homo sapiens
Gustafsson, J.
Bile acid synthesis during development. Mitochondrial 12alpha-hydroxylation in human fetal liver
J. Clin. Invest.
75
604-607
1985
Homo sapiens
Inoue, Y.; Yu, A.M.; Yim, S.H.; Ma, X.; Krausz, K.W.; Inoue, J.; Xiang, C.C.; Brownstein, M.J.; Eggertsen, G.; Bjorkhem, I.; Gonzalez, F.J.
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha
J. Lipid Res.
47
215-227
2006
Mus musculus
Noshiro, M.; Ishida, H.; Hayashi, S.; Okuda, K.
Assays for cholesterol 7alpha-hydroxylase and 12alpha-hydroxylase using high performance liquid chromatography
Steroids
45
539-550
1985
Rattus norvegicus
Murphy, C.; Parini, P.; Wang, J.; Bjoerkhem, I.; Eggertsen, G.; Gafvels, M.
Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
Biochim. Biophys. Acta
1735
167-175
2005
Mus musculus
Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse
Histochem. Cell Biol.
127
253-261
2007
Mus musculus
Sehayek, E.; Hagey, L.R.; Fung, Y.Y.; Duncan, E.M.; Yu, H.J.; Eggertsen, G.; Bjoerkhem, I.; Hofmann, A.F.; Breslow, J.L.
Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit
J. Lipid Res.
47
2020-2027
2006
Mus musculus
Chen, W.; Suruga, K.; Nishimura, N.; Gouda, T.; Lam, V.N.; Yokogoshi, H.
Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats
Life Sci.
77
746-757
2005
Mus musculus, Rattus norvegicus
Abrahamsson, A.; Gafvels, M.; Reihner, E.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.
Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile
Scand. J. Clin. Lab. Invest.
65
595-600
2005
Homo sapiens
Ellis, E.C.
Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes
World J. Gastroenterol.
12
4640-4645
2006
Homo sapiens
Lundell, K.; Wikvall, K.
Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis
Curr. Drug Metab.
9
323-331
2008
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Li, Y.; Mezei, O.; Shay, N.F.
Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones
J. Nutr.
137
1705-1712
2007
Homo sapiens, Mus musculus
Zollner, G.; Wagner, M.; Fickert, P.; Silbert, D.; Gumhold, J.; Zatloukal, K.; Denk, H.; Trauner, M.
Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
Liver Int.
27
920-929
2007
Homo sapiens
Lee, Y.K.; Schmidt, D.R.; Cummins, C.L.; Choi, M.; Peng, L.; Zhang, Y.; Goodwin, B.; Hammer, R.E.; Mangelsdorf, D.J.; Kliewer, S.A.
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis
Mol. Endocrinol.
22
1345-1356
2008
Mus musculus
Sanyal, S.; Bavner, A.; Haroniti, A.; Nilsson, L.M.; Lundasen, T.; Rehnmark, S.; Witt, M.R.; Einarsson, C.; Talianidis, I.; Gustafsson, J.A.; Treuter, E.
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
Proc. Natl. Acad. Sci. USA
104
15665-15670
2007
Homo sapiens
Wooton-Kee, C.; Cohen, D.; Vore, M.
Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat
Am. J. Physiol. Gastrointest. Liver Physiol.
294
G1009-G1016
2008
Rattus norvegicus
Liu, Y.; Havinga, R.; VAN DER Leij, F.R.; Boverhof, R.; Sauer, P.J.; Kuipers, F.; Stellaard, F.
Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics
Pediatr. Res.
63
375-381
2008
Rattus norvegicus
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