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Information on EC 1.14.14.105 - taxane 10beta-hydroxylase

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IUBMB Comments
This microsomal cytochrome-P-450 (heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
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The expected taxonomic range for this enzyme is: Taxus
Synonyms
5-alpha-taxadienol-10-beta-hydroxylase, cytochrome P450 reductase, NADPH:cytochrome P450 reductase, oxygenase, taxane 10beta-mono-, taxa-4(20),11-dien-5alpha-yl acetate 10beta-hydroxylase, taxadien-5alpha-yl-acetate 10beta-hydroxylase, taxane 10beta-hydroxylase, taxane 10beta-monooxygenase, taxoid 10beta-hydroxylase, THY10b, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taxa-4(20),11-dien-5alpha-yl acetate + [reduced NADPH-hemoprotein reductase] + O2 = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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