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Reference on EC 1.14.14.1 - unspecific monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lang, M.A.; Nebert, D.W.
Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes
J. Biol. Chem.
256
12058-12067
1981
Mus musculus
Manually annotated by BRENDA team
Lang, M.A.; Gielen, J.E.; Nebert, D.W.
Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice
J. Biol. Chem.
256
12068-12075
1981
Mus musculus
Manually annotated by BRENDA team
Theoharides, A.D.; Kupfer, D.
Evidence for different hepatic microsomal monooxygenases catalyzing omega- and (omega-1)-hydroxylations of prostaglandins E1 and E2. Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation
J. Biol. Chem.
256
2168-2175
1981
Rattus norvegicus
Manually annotated by BRENDA team
Oliver, C.F.; Modi, S.; Primrose, W.U.; Lian, L.Y.; Roberts, G.C.K.
Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds
Biochem. J.
327
537-544
1997
Priestia megaterium
-
Manually annotated by BRENDA team
Sevrioukova, I.F.; Li, H.; Zhang, H.; Peterson, J.A.; Poulos, T.L.
Structure of a cytochrome P450-redox partner electron-transfer complex
Proc. Natl. Acad. Sci. USA
96
1863-1868
1999
Priestia megaterium
Manually annotated by BRENDA team
Eschenfeldt, W.H.; Zhang, Y.; Samaha, H.; Stols, L.; Eirich, L.D.; Wilson, C.R.; Donnelly, M.I.
Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis
Appl. Environ. Microbiol.
69
5992-5999
2003
Candida tropicalis
Manually annotated by BRENDA team
Gewonyo, K.; Buckland, B.C.; Lilly, M.D.
Development of a large-scale continuous substrate to feed process for the biotransformation of simvastatin by Nocardia sp.
Biotechnol. Bioeng.
37
1101-1107
1991
Pseudonocardia autotrophica
Manually annotated by BRENDA team
Cashman, J.R.; Lattard, V.; Lin, J.
Effect of total parenteral nutrition and choline on hepatic flavin-containing and cytochrome P-450 monooxygenase activity in rats
Drug Metab. Dispos.
32
222-229
2004
Rattus norvegicus
Manually annotated by BRENDA team
Chen, J.S.; Berenbaum, M.R.; Schuler, M.A.
Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase
Insect Mol. Biol.
11
175-186
2002
Papilio polyxenes (Q04552), Papilio polyxenes
Manually annotated by BRENDA team
Hirose, S.; Kawahigashi, H.; Ozawa, K.; Shiota, N.; Inui, H.; Ohkawa, H.; Ohkawa, Y.
Transgenic rice containing human CYP2B6 detoxifies various classes of herbicides
J. Agric. Food Chem.
53
3461-3467
2005
Homo sapiens
Manually annotated by BRENDA team
Lentz, O.; Urlacher, V.; Schmid, R.D.
Substrate specificity of native and mutated cytochrome P450 (CYP102A3) from Bacillus subtilis
J. Biotechnol.
108
41-49
2004
Bacillus subtilis
Manually annotated by BRENDA team
Kikuta, Y.; Kusunose, E.; Kusunose, M.
Prostaglandin and leukotriene omega-hydroxylases
Prostaglandins
68-69
345-362
2002
Oryctolagus cuniculus
Manually annotated by BRENDA team
Baudry, J.; Li, W.; Pan, L.; Berenbaum, M.R.; Schuler, M.A.
Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome P450 monooxygenase
Protein Eng.
16
577-587
2003
Papilio polyxenes
Manually annotated by BRENDA team
Lee, S.K.; Basnet, D.B.; Hong, J.S.; Jung, W.S.; Choi, C.Y.; Lee, H.C.; Sohng, J.K.; Ryu, K.G.; Kim, D.J.; Ahn, J.S.; Kim, B.S.; Oh, H.C.; Sherman, D.H.; Yoon, Y.J.
Structural diversification of macrolactones by substrate-flexible cytochrome P450 monooxygenases
Adv. Synth. Catal.
347
1369-1378
2005
Streptomyces venezuelae
-
Manually annotated by BRENDA team
Henczova, M.; Deer, A.K.; Komlosi, V.; Mink, J.
Detection of toxic effects of Cd(2+) on different fish species via liver cytochrome P450-dependent monooxygenase activities and FTIR spectroscopy
Anal. Bioanal. Chem.
385
652-659
2006
Cyprinus carpio, Silurus glanis, Hypophthalmichthys molitrix
Manually annotated by BRENDA team
Jungmann, V.; Molnar, I.; Hammer, P.E.; Hill, D.S.; Zirkle, R.; Buckel, T.G.; Buckel, D.; Ligon, J.M.; Pachlatko, J.P.
Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes
Appl. Environ. Microbiol.
71
6968-6976
2005
Streptomyces sp., Streptomyces tubercidicus
Manually annotated by BRENDA team
Liu, L.; Schmid, R.D.; Urlacher, V.B.
Cloning, expression, and characterization of a self-sufficient cytochrome P450 monooxygenase from Rhodococcus ruber DSM 44319
Appl. Microbiol. Biotechnol.
72
876-882
2006
Rhodococcus ruber (Q52TE7), Rhodococcus ruber
Manually annotated by BRENDA team
Johnson, E.F.; Stout, C.D.
Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases
Biochem. Biophys. Res. Commun.
338
331-336
2005
Homo sapiens
Manually annotated by BRENDA team
Cashman, J.R.
Some distinctions between flavin-containing and cytochrome P450 monooxygenases
Biochem. Biophys. Res. Commun.
338
599-604
2005
Homo sapiens
Manually annotated by BRENDA team
Roccatano, D.; Wong, T.S.; Schwaneberg, U.; Zacharias, M.
Toward understanding the inactivation mechanism of monooxygenase P450 BM-3 by organic cosolvents: a molecular dynamics simulation study
Biopolymers
83
467-476
2006
Priestia megaterium (P14779), Priestia megaterium
Manually annotated by BRENDA team
Vatsyayan, P.; Kumar, A.K.; Goswami, P.; Goswami, P.
Broad substrate cytochrome P450 monooxygenase activity in the cells of Aspergillus terreus MTCC 6324
Biores. Technol.
99
68-75
2007
Aspergillus terreus, Aspergillus terreus MTCC 6324
Manually annotated by BRENDA team
Gorinova, N.; Nedkovska, M.; Atanassov, A.
Cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Biotechnol. Biotechnol. Equip.
19
105-115
2005
Homo sapiens, Lolium rigidum, Nicotiana tabacum, Phelipanche ramosa, Rattus norvegicus, Solanum tuberosum, Sorghum sp., Triticum aestivum, Zea mays
-
Manually annotated by BRENDA team
Doddapaneni, H.; Chakraborty, R.; Yadav, J.S.
Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: Evidence for gene duplications and extensive gene clustering
BMC Genomics
6
92
2005
Phanerodontia chrysosporium, Phanerodontia chrysosporium (Q4G2S1), Phanerodontia chrysosporium (Q4G2S2), Phanerodontia chrysosporium (Q4G2S3), Phanerodontia chrysosporium (Q4L230), Phanerodontia chrysosporium (Q4L231), Phanerodontia chrysosporium BKM-F-1767, Phanerodontia chrysosporium BKM-F-1767 (Q4G2S1), Phanerodontia chrysosporium BKM-F-1767 (Q4G2S2), Phanerodontia chrysosporium BKM-F-1767 (Q4G2S3), Phanerodontia chrysosporium BKM-F-1767 (Q4L230), Phanerodontia chrysosporium BKM-F-1767 (Q4L231)
Manually annotated by BRENDA team
Haarmann, T.; Ortel, I.; Tudzynski, P.; Keller, U.
Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways
Chembiochem
7
645-652
2006
Claviceps purpurea, Claviceps purpurea P1
Manually annotated by BRENDA team
Arun, S.; Rajendran, A.; Subramanian, P.
Subcellular/tissue distribution and responses to oil exposure of the cytochrome P450-dependent monooxygenase system and glutathione S-transferase in freshwater prawns (Macrobrachium malcolmsonii, M. lamarrei lamarrei)
Ecotoxicology
15
341-346
2006
Macrobrachium lamarrei, Macrobrachium malcolmsonii
Manually annotated by BRENDA team
Chan, P.K.; Lu, S.Y.; Liao, J.W.; Wei, C.F.; Tsai, Y.; Ueng, T.H.
Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol
Food Chem. Toxicol.
44
2047-2057
2006
Rattus norvegicus
Manually annotated by BRENDA team
Alvarez, V.; Rodriguez-Saiz, M.; de la Fuente, J.L.; Gudina, E.J.; Godio, R.P.; Martin, J.F.; Barredo, J.L.
The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls
Fungal Genet. Biol.
43
261-272
2006
Phaffia rhodozyma
Manually annotated by BRENDA team
Hirao, J.; Arakawa, S.; Watanabe, K.; Ito, K.; Furukawa, T.
Effects of restricted feeding on daily fluctuations of hepatic functions including P450 monooxygenase activities in rats
J. Biol. Chem.
281
3165-3171
2006
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, Y.; White, M.A.; Muralidhara, B.K.; Sun, L.; Halpert, J.R.; Stout, C.D.
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction
J. Biol. Chem.
281
5973-5981
2006
Oryctolagus cuniculus
Manually annotated by BRENDA team
Eiben, S.; Kaysser, L.; Maurer, S.; Kuehnel, K.; Urlacher, V.B.; Schmid, R.D.
Preparative use of isolated CYP102 monooxygenases - a critical appraisal
J. Biotechnol.
124
662-669
2006
Priestia megaterium, Bacillus subtilis
Manually annotated by BRENDA team
Zeng, R.S.; Niu, G.; Wen, Z.; Schuler, M.A.; Berenbaum, M.R.
Toxicity of aflatoxin B1 to Helicoverpa zea and bioactivation by cytochrome P450 monooxygenases
J. Chem. Ecol.
32
1459-1471
2006
Helicoverpa zea
Manually annotated by BRENDA team
Ito, O.; Nakamura, Y.; Tan, L.; Ishizuka, T.; Sasaki, Y.; Minami, N.; Kanazawa, M.; Ito, S.; Sasano, H.; Kohzuki, M.
Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human
Mol. Cell. Biochem.
284
141-148
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Yun, M.; Yogo, Y.; Miura, R.; Yamasue, Y.; Fischer, A.J.
Cytochrome P-450 monooxygenase activity in herbicide-resistant and -susceptible late watergrass (Echinochloa phyllopogon)
Pestic. Biochem. Physiol.
83
107-114
2005
Echinochloa phyllopogon
-
Manually annotated by BRENDA team
Zhu, Y.; Nomura, T.; Xu, Y.; Zhang, Y.; Peng, Y.; Mao, B.; Hanada, A.; Zhou, H.; Wang, R.; Li, P.; Zhu, X.; Mander, L.N.; Kamiya, Y.; Yamaguchi, S.; He, Z.
Elongated uppermost internode encodes a cytochrome P450 monooxygenase that epoxidizes gibberellins in a novel deactivation reaction in rice
Plant Cell
18
442-456
2006
Oryza sativa (Q5KQH7), Oryza sativa
Manually annotated by BRENDA team
Siminszky, B.; Gavilano, L.; Bowen, S.W.; Dewey, R.E.
Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase
Proc. Natl. Acad. Sci. USA
102
14919-14924
2005
Nicotiana tabacum (Q38Q84), Nicotiana tabacum (Q38Q85), Nicotiana tabacum (Q38Q86), Nicotiana tabacum (Q38Q87), Nicotiana tabacum
Manually annotated by BRENDA team
Kranendonk, M.; Marohnic, C.C.; Panda, S.P.; Duarte, M.P.; Oliveira, J.S.; Masters, B.S.; Rueff, J.
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
475
93-99
2008
Homo sapiens
Manually annotated by BRENDA team
Henczova, M.; Deer, A.K.; Filla, A.; Komlosi, V.; Mink, J.
Effects of Cu(2+) and Pb(2+) on different fish species: liver cytochrome P450-dependent monooxygenase activities and FTIR spectra
Comp. Biochem. Physiol. C
148
53-60
2008
Cyprinus carpio, Silurus glanis, Hypophthalmichthys molitrix
Manually annotated by BRENDA team
Panicco, P.; Astuti, Y.; Fantuzzi, A.; Durrant, J.R.; Gilardi, G.
P450 versus P420: Correlation between Cyclic Voltammetry and Visible Absorption Spectroscopy of the Immobilized Heme Domain of Cytochrome P450 BM3
J. Phys. Chem. B
112
14063
2008
Priestia megaterium (P14779), Priestia megaterium
Manually annotated by BRENDA team
Branco, R.J.; Seifert, A.; Budde, M.; Urlacher, V.B.; Ramos, M.J.; Pleiss, J.
Anchoring effects in a wide binding pocket: The molecular basis of regioselectivity in engineered cytochrome P450 monooxygenase from B. megaterium
Proteins
73
597-607
2008
Priestia megaterium (P14779), Priestia megaterium
Manually annotated by BRENDA team
Liu, J.F.; Guiguen, Y.; Liu, S.J.
Aromatase (P450arom) and 11beta-hydroxylase (P45011beta) genes are differentially expressed during the sex change process of the protogynous rice field eel, Monopterus albus
Fish Physiol. Biochem.
35
511-518
2009
Monopterus albus (Q2I129), Monopterus albus
Manually annotated by BRENDA team
Pachecka, J.; Tomaszewski, P.; Kubiak-Tomaszewska, G.
Cytochrome P450 polymorphism--molecular, metabolic and pharmacogenetic aspects. I. Mechanisms of activity of cytochrome P450 monooxygenases
Acta Pol. Pharm.
65
303-306
2008
Homo sapiens
Manually annotated by BRENDA team
Subramanian, V.; Yadav, J.S.
Role of P450 monooxygenases in the degradation of the endocrine-disrupting chemical nonylphenol by the white rot fungus Phanerochaete chrysosporium
Appl. Environ. Microbiol.
75
5570-5580
2009
Phanerodontia chrysosporium, Phanerodontia chrysosporium BKM-F-1767
Manually annotated by BRENDA team
Dietrich, M.; Eiben, S.; Asta, C.; Do, T.A.; Pleiss, J.; Urlacher, V.B.
Cloning, expression and characterisation of CYP102A7, a self-sufficient P450 monooxygenase from Bacillus licheniformis
Appl. Microbiol. Biotechnol.
79
931-940
2008
Bacillus licheniformis, Bacillus licheniformis DSM 13
Manually annotated by BRENDA team
Zhang, J.D.; Li, A.T.; Yang, Y.; Xu, J.H.
Sequence analysis and heterologous expression of a new cytochrome P450 monooxygenase from Rhodococcus sp. for asymmetric sulfoxidation
Appl. Microbiol. Biotechnol.
85
615-624
2010
Rhodococcus sp.
Manually annotated by BRENDA team
Pekthong, D.; Blanchard, N.; Abadie, C.; Bonet, A.; Heyd, B.; Mantion, G.; Berthelot, A.; Richert, L.; Martin, H.
Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures
Chem. Biol. Interact.
179
247-255
2009
Homo sapiens, Homo sapiens (P05177), Rattus norvegicus (P04799), Rattus norvegicus (P04800), Rattus norvegicus (P05182), Rattus norvegicus (P08683)
Manually annotated by BRENDA team
Robin, A.; Roberts, G.A.; Kisch, J.; Sabbadin, F.; Grogan, G.; Bruce, N.; Turner, N.J.; Flitsch, S.L.
Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme
Chem. Commun. (Camb. )
0
2478-2480
2009
synthetic construct
Manually annotated by BRENDA team
Liu, Y.; Glatt, H.
Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis
Environ. Mol. Mutagen.
51
23-30
2010
Homo sapiens
Manually annotated by BRENDA team
Wright, A.T.; Song, J.D.; Cravatt, B.F.
A suite of activity-based probes for human cytochrome P450 enzymes
J. Am. Chem. Soc.
131
10692-10700
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, C.K.; Berry, R.E.; Shokhireva, T.K.; Murataliev, M.B.; Zhang, H.; Walker, F.A.
Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7
J. Biol. Inorg. Chem.
15
159-174
2010
Priestia megaterium (P14779)
Manually annotated by BRENDA team
Tam, T.W.; Liu, R.; Arnason, J.T.; Krantis, A.; Staines, W.A.; Haddad, P.S.; Foster, B.C.
Actions of ethnobotanically selected Cree anti-diabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3
J. Ethnopharmacol.
126
119-126
2009
Homo sapiens, Homo sapiens (P05177), Homo sapiens (P10632), Homo sapiens (P10635), Homo sapiens (P20813), Homo sapiens (P20815), Homo sapiens (P24462)
Manually annotated by BRENDA team
Hardstone, M.C.; Leichter, C.A.; Scott, J.G.
Multiplicative interaction between the two major mechanisms of permethrin resistance, kdr and cytochrome P450-monooxygenase detoxification, in mosquitoes
J. Evol. Biol.
22
416-423
2009
Culex quinquefasciatus
Manually annotated by BRENDA team
Acharya, P.; Engel, J.C.; Correia, M.A.
Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK)
Mol. Pharmacol.
76
503-515
2009
Rattus norvegicus
Manually annotated by BRENDA team
Diczfalusy, U.; Miura, J.; Roh, H.K.; Mirghani, R.A.; Sayi, J.; Larsson, H.; Bodin, K.G.; Allqvist, A.; Jande, M.; Kim, J.W.; Aklillu, E.; Gustafsson, L.L.; Bertilsson, L.
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
Pharmacogenet. Genomics
18
201-208
2008
Homo sapiens (P20815), Homo sapiens
Manually annotated by BRENDA team
Page, V.; Schwitzguebel, J.P.
Metabolism of sulphonated anthraquinones in rhubarb, maize and celery: the role of cytochromes P450 and peroxidases
Plant Cell Rep.
28
1725-1735
2009
Apium graveolens, Zea mays, Rheum rhaponticum
Manually annotated by BRENDA team
Pan, Y.; Michael, T.P.; Hudson, M.E.; Kay, S.A.; Chory, J.; Schuler, M.A.
Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways
Plant Physiol.
150
858-878
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Furuya, T.; Shibata, D.; Kino, K.
Phylogenetic analysis of Bacillus P450 monooxygenases and evaluation of their activity towards steroids
Steroids
74
906-912
2009
Bacillus cereus, Bacillus cereus (Q735A2), Bacillus cereus (Q735B3), Bacillus cereus (Q737F3), Bacillus cereus (Q737I9), Bacillus cereus (Q737J4)
Manually annotated by BRENDA team
Leoni, C.; Buratti, F.M.; Testai, E.
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion
Toxicol. Appl. Pharmacol.
233
343-352
2008
Homo sapiens, Homo sapiens (P05177), Homo sapiens (P10632), Homo sapiens (P10635), Homo sapiens (P11509), Homo sapiens (P20813)
Manually annotated by BRENDA team
Zhang, X.; Moore, J.N.; Newsted, J.L.; Hecker, M.; Zwiernik, M.J.; Jones, P.D.; Bursian, S.J.; Giesy, J.P.
Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds
Toxicol. Appl. Pharmacol.
234
306-313
2009
Neogale vison (A7UDB5), Neogale vison (A7UDB6)
Manually annotated by BRENDA team
Beedanagari, S.R.; Bebenek, I.; Bui, P.; Hankinson, O.
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes
Toxicol. Sci.
110
61-67
2009
Homo sapiens
Manually annotated by BRENDA team
Nayeem, M.A.; Zeldin, D.C.; Boegehold, M.A.; Morisseau, C.; Marowsky, A.; Ponnoth, D.S.; Roush, K.P.; Falck, J.R.
Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
299
R325-R333
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Lamb, D.C.; Lei, L.; Zhao, B.; Yuan, H.; Jackson, C.J.; Warrilow, A.G.; Skaug, T.; Dyson, P.J.; Dawson, E.S.; Kelly, S.L.; Hachey, D.L.; Waterman, M.R.
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner
Appl. Environ. Microbiol.
76
1975-1980
2010
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Manually annotated by BRENDA team
Flueck, C.E.; Mullis, P.E.; Pandey, A.V.
Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism
Biochem. Biophys. Res. Commun.
401
149-153
2010
Homo sapiens
Manually annotated by BRENDA team
Zhang, J.; Li, A.; Xu, J.
Improved expression of recombinant cytochrome P450 monooxygenase in Escherichia coli for asymmetric oxidation of sulfides
Bioprocess Biosyst. Eng.
33
1043-1049
2010
Rhodococcus sp.
Manually annotated by BRENDA team
Liu, L.; Schmid, R.D.; Urlacher, V.B.
Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity
Biotechnol. Lett.
32
841-845
2010
Rhodococcus ruber
Manually annotated by BRENDA team
Brignac-Huber, L.; Reed, J.R.; Backes, W.L.
Organization of NADPH-cytochrome P450 reductase and CYP1A2 in the endoplasmic reticulum - microdomain localization affects monooxygenase function
Mol. Pharmacol.
79
549-557
2011
Oryctolagus cuniculus
Manually annotated by BRENDA team
Platt, K.L.; Edenharder, R.; Aderhold, S.; Muckel, E.; Glatt, H.
Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells
Mutat. Res.
703
90-98
2010
Homo sapiens
Manually annotated by BRENDA team
Kobayashi, K.; Yamamoto, T.; Taguchi, M.; Chiba, K.
High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent
Anal. Biochem.
284
342-347
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Syed, K.; Porollo, A.; Lam, Y.W.; Grimmett, P.E.; Yadav, J.S.
CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes
Appl. Environ. Microbiol.
79
2692-2702
2013
Phanerodontia chrysosporium
Manually annotated by BRENDA team
Schallmey, A.; Den Besten, G.; Teune, I.; Kembaren, R.; Janssen, D.
Characterization of cytochrome P450 monooxygenase CYP154H1 from the thermophilic soil bacterium Thermobifida fusca
Appl. Microbiol. Biotechnol.
89
1475-1485
2011
Thermobifida fusca
Manually annotated by BRENDA team
Wang, S.P.; He, G.L.; Chen, R.R.; Li, F.; Li, G.Q.
The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae
Arch. Insect Biochem. Physiol.
79
264-275
2012
Drosophila melanogaster
Manually annotated by BRENDA team
Ide, M.; Ichinose, H.; Wariishi, H.
Molecular identification and functional characterization of cytochrome P450 monooxygenases from the brown-rot basidiomycete Postia placenta
Arch. Microbiol.
194
243-253
2012
Postia placenta, Postia placenta MAD-698
Manually annotated by BRENDA team
Misra, A.; Chanotiya, C.S.; Gupta, M.M.; Dwivedi, U.N.; Shasany, A.K.
Characterization of cytochrome P450 monooxygenases isolated from trichome enriched fraction of Artemisia annua L. leaf
Gene
510
193-201
2012
Artemisia annua (Q2EPZ0), Artemisia annua
Manually annotated by BRENDA team
Lah, L.; Podobnik, B.; Novak, M.; Korosec, B.; Berne, S.; Vogelsang, M.; Krasevec, N.; Zupanec, N.; Stojan, J.; Bohlmann, J.; Komel, R.
The versatility of the fungal cytochrome P450 monooxygenase system is instrumental in xenobiotic detoxification
Mol. Microbiol.
81
1374-1389
2011
Curvularia lunata
Manually annotated by BRENDA team
Syed, K.; Porollo, A.; Miller, D.; Yadav, J.
Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons
Protein Eng.
26
553-557
2013
Phanerodontia chrysosporium
Manually annotated by BRENDA team
Roiban, G.; Agudo, R.; Ilie, A.; Lonsdale, R.; Reetz, M.
CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity
Chem. Commun. (Camb.)
50
14310-14313
2014
Priestia megaterium (P14779), Priestia megaterium ATCC 14581 (P14779)
Manually annotated by BRENDA team
Kolrep, F.; Hessel, S.; These, A.; Ehlers, A.; Rein, K.; Lampen, A.
Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases
Arch. Toxicol.
90
2025-2036
2016
Homo sapiens, Rattus norvegicus (P04799), Rattus norvegicus (P04800)
Manually annotated by BRENDA team
Matowane, R.; Wieteska, L.; Bamal, H.; Kgosiemang, I.; Van Wyk, M.; Manume, N.; Abdalla, S.; Mashele, S.; Gront, D.; Syed, K.
In silico analysis of cytochrome P450 monooxygenases in chrgranulomatous infectious fungus onic Sporothrix schenckii Special focus on CYP51
Biochim. Biophys. Acta
1866
166-177
2018
Sporothrix schenckii (U7Q7I7), Sporothrix schenckii, Sporothrix schenckii ATCC 58251 (U7Q7I7)
Manually annotated by BRENDA team
Yin, Y.; Yu, H.; Luan, Z.; Li, R.; Ouyang, P.; Liu, J.; Xu, J.
Unusually broad substrate profile of self-sufficient Cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata
ChemBioChem
15
2443-2449
2014
Roseibium aggregatum (A0P0F6), Roseibium aggregatum DSM 13394 (A0P0F6)
Manually annotated by BRENDA team
Wriessnegger, T.; Moser, S.; Emmerstorfer-Augustin, A.; Leitner, E.; Mueller, M.; Kaluzna, I.; Schuermann, M.; Mink, D.; Pichler, H.
Enhancing cytochrome P450-mediated conversions in P. pastoris through RAD52 over-expression and optimizing the cultivation conditions
Fungal Genet. Biol.
89
114-125
2016
Homo sapiens (P10635), Homo sapiens
Manually annotated by BRENDA team
Lee, H.; Kim, B.; Ahn, J.
Production of bioactive hydroxyflavones by using monooxygenase from Saccharothrix espanaensis
J. Biotechnol.
176
11-17
2014
Saccharothrix espanaensis (Q2EYY8)
Manually annotated by BRENDA team
Tosstorff, A.; Dennig, A.; Ruff, A.; Schwaneberg, U.; Sieber, V.; Mangold, K.; Schrader, J.; Holtmann, D.
Mediated electron transfer with monooxygenases - Insight in interactions between reduced mediators and the co-substrate oxygen
J. Mol. Catal. B
108
51-58
2014
Priestia megaterium (P14779), Priestia megaterium DSM 32 (P14779)
-
Manually annotated by BRENDA team
Hasegawa, E.; Inafuku, S.; Mulki, L.; Okunuki, Y.; Yanai, R.; Smith, K.; Kim, C.; Klokman, G.; Bielenberg, D.; Puli, N.; Falck, J.; Husain, D.; Miller, J.; Edin, M.; Zeldin, D.; Lee, K.; Hammock, B.; Schunck, W.; Connor, K.
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization
Proc. Natl. Acad. Sci. USA
114
E7545-E7553
2017
Homo sapiens
Manually annotated by BRENDA team
Lavado, R.; Li, J.; Rimoldi, J.; Schlenk, D.
Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes Contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites
Toxicol. Lett.
226
192-197
2014
Homo sapiens
Manually annotated by BRENDA team
Lau, I.; Feyereisen, R.; Nelson, D.; Bell, S.
Analysis and preliminary characterisation of the cytochrome P450 monooxygenases from Frankia sp. EuI1c (Frankia inefficax sp.)
Arch. Biochem. Biophys.
669
11-21
2019
Frankia inefficax (E3J2L4), Frankia inefficax (E3J531), Frankia inefficax (E3J9F8), Frankia inefficax DSM 45817 (E3J2L4), Frankia inefficax DSM 45817 (E3J531), Frankia inefficax DSM 45817 (E3J9F8)
Manually annotated by BRENDA team
Connick, J.P.; Reed, J.R.; Cawley, C.F.; Backes, W.L.
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1
Biochem. J.
478
377-388
2021
Homo sapiens (P04798), Homo sapiens
Manually annotated by BRENDA team
Valikhani, D.; Bolivar, J.; Dennig, A.; Nidetzky, B.
A tailor-made, self-sufficient and recyclable monooxygenase catalyst based on coimmobilized cytochrome P450 BM3 and glucose dehydrogenase
Biotechnol. Bioeng.
115
2416-2425
2018
Priestia megaterium (P14779), Priestia megaterium DSM 32 (P14779)
-
Manually annotated by BRENDA team
Nair, P.C.; Gillani, T.B.; Rawling, T.; Murray, M.
Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite
Chem. Biol. Interact.
338
109401
2021
Homo sapiens (P10632), Homo sapiens (P11712), Homo sapiens
Manually annotated by BRENDA team
Tang, L.W.T.; Teng, J.W.; Koh, S.K.; Zhou, L.; Go, M.L.; Chan, E.C.Y.
Mechanism-based inactivation of cytochrome P450 3A4 and 3A5 by the fibroblast growth factor receptor inhibitor erdafitinib
Chem. Res. Toxicol.
34
1800-1813
2021
Homo sapiens (P20815), Homo sapiens (Q9HB55)
Manually annotated by BRENDA team
Mukherjee, G.; Nandekar, P.P.; Wade, R.C.
An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
Commun. Biol.
4
55
2021
Homo sapiens (P04798)
Manually annotated by BRENDA team
Indra, R.; Pompach, P.; Vavrova, K.; Jaklova, K.; Heger, Z.; Adam, V.; Eckschlager, T.; Kopeckova, K.; Arlt, V.A.; Stiborova, M.
Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
Environ. Toxicol. Pharmacol.
74
103310
2020
Rattus norvegicus (P08683)
Manually annotated by BRENDA team
Zhang, L.; Xie, Z.; Liu, Z.; Zhou, S.; Ma, L.; Liu, W.; Huang, J.; Ko, T.; Li, X.; Hu, Y.; Min, J.; Yu, X.; Guo, R.; Chen, C.
Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase
Nat. Commun.
11
2676
2020
Tepidiphilus thermophilus (A0A0K6ITW2)
Manually annotated by BRENDA team