Disease on EC 1.14.13.9 - kynurenine 3-monooxygenase
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Acquired Immunodeficiency Syndrome
Tryptophan metabolism in relation to amino acid alterations during typhoid fever.
Alzheimer Disease
A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.
Alzheimer Disease
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Alzheimer Disease
Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.
Alzheimer Disease
Metabolism and Pharmacokinetics of JM6 in Mice: JM6 is Not a Prodrug for Ro-61-8048.
Alzheimer Disease
Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.
Alzheimer Disease
Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii.
Astrocytoma
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
Brain Diseases
Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases.
Brain Edema
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
Brain Edema
[Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat shock protein, nitric oxide synthase and inflammatory cytokines in contusion cerebral edema]
Brain Edema
[Effects of cinnabar and realgar in angong niuhuang powder on lactate dehydrogenase and its isoenzymes in rats with infectious cerebral edema]
Brain Injuries
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
Brain Injuries
Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.
Brain Ischemia
Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia.
Brain Ischemia
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
Brain Ischemia
[Absorption and distribution of mercury and arsenic from realgar and cinnabar of angong niuhuang pill in normal rats and rats with cerebral ischemia]
Breast Neoplasms
Kynurenine 3-monooxygenase upregulates pluripotent genes through ?-catenin and promotes triple-negative breast cancer progression.
Breast Neoplasms
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Carcinogenesis
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Carcinogenesis
Kynurenine 3-monooxygenase upregulates pluripotent genes through ?-catenin and promotes triple-negative breast cancer progression.
Carcinogenesis
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Carcinoma, Hepatocellular
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Carcinoma, Hepatocellular
Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.
Central Nervous System Neoplasms
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Chorea
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Cluster Headache
The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents.
Colitis
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
Colitis
Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.
Colorectal Neoplasms
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer.
Colorectal Neoplasms
Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.
COVID-19
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Dyskinesias
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: Common implication of striatal neuropeptides.
Dyskinesias
Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.
Dyskinesias
Implication of NMDA Receptors in the Antidyskinetic Activity of Cabergoline, CI-1041, and Ro 61-8048 in MPTP Monkeys with Levodopa-induced Dyskinesias.
Dyskinesias
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
Dyskinesias
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Dystonia
Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.
Dystonia
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Encephalomyelitis, Autoimmune, Experimental
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
Endotoxemia
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Gastritis
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Hearing Loss
Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na(+)/K(+)-ATPase activities.
Huntington Disease
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.
Huntington Disease
Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington's disease.
Huntington Disease
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.
Huntington Disease
Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.
Huntington Disease
Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.
Huntington Disease
Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington's Disease.
Huntington Disease
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Huntington Disease
Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO).
Huntington Disease
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor.
Huntington Disease
First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists!
Huntington Disease
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Huntington Disease
Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntington's Disease.
Huntington Disease
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Hyperalgesia
Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.
Hyperpigmentation
An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies.
Hypersensitivity
Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
Hypotension
Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?
Infarction, Middle Cerebral Artery
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
Infections
A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.
Infections
Antiviral Effect of IDO in Mouse Fibroblast Cells During Influenza Virus Infection.
Infections
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
Infections
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Infections
Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight.
Ischemic Attack, Transient
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
Ischemic Stroke
Heterologous expression and purification of kynurenine-3-monooxygenase from Pseudomonas fluorescens strain 17400.
kynurenine 3-monooxygenase deficiency
Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of ?7 nicotinic acetylcholine receptors by kynurenic acid.
kynurenine 3-monooxygenase deficiency
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
kynurenine 3-monooxygenase deficiency
Peripheral kynurenine-3-monooxygenase deficiency as a potential risk factor for metabolic syndrome in schizophrenia patients.
Leiomyomatosis
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Malaria
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.
Mania
Differences in kynurenine metabolism during depressive, manic, and euthymic phases of bipolar affective disorder.
Mania
The KMO allele encoding Arg(452) is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.
Melanoma
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Meningitis, Bacterial
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.
Mercury Poisoning
Chronic mercury exposure in Late Neolithic/Chalcolithic populations in Portugal from the cultural use of cinnabar.
Metabolic Syndrome
Peripheral kynurenine-3-monooxygenase deficiency as a potential risk factor for metabolic syndrome in schizophrenia patients.
Multiple Sclerosis
Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System.
Myocarditis
Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
Neoplasm Metastasis
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer.
Neoplasm Metastasis
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Neoplasms
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Neoplasms
Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.
Neoplasms
Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway.
Neoplasms
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Neoplasms
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Neoplasms
Kynurenine 3-monooxygenase upregulates pluripotent genes through ?-catenin and promotes triple-negative breast cancer progression.
Neoplasms
Kynurenine-3-monooxygenase: A new direction for the treatment in different diseases.
Neoplasms
Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors.
Neoplasms
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Neoplasms
Targeting tryptophan catabolic kynurenine pathway enhances antitumor immunity and cytotoxicity in multiple myeloma.
Neoplasms
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Neoplasms
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Neoplasms
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Nephritis, Interstitial
Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity.
Nervous System Diseases
Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
Nervous System Diseases
Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide.
Neuralgia
Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
Neuralgia
Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.
Neuralgia
The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents.
Neuralgia
Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.
Neurodegenerative Diseases
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.
Neurodegenerative Diseases
A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.
Neurodegenerative Diseases
A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.
Neurodegenerative Diseases
Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases.
Neurodegenerative Diseases
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Neurodegenerative Diseases
Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.
Neurodegenerative Diseases
Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO).
Neurodegenerative Diseases
Dual Role of the Carboxyl-terminal Region of Pig Liver L-Kynurenine 3-Monooxygenase: Mitochondrial Targeting Signal and Enzymatic Activity.
Neurodegenerative Diseases
First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists!
Neurodegenerative Diseases
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Neurodegenerative Diseases
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Neurodegenerative Diseases
Kynurenine Monooxygenase (KMO) Inhibitors for the Treatment of Acute Pancreatitis and Neurodegenerative Disorders.
Neurodegenerative Diseases
Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.
Neurodegenerative Diseases
Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats.
Neurodegenerative Diseases
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Neurodegenerative Diseases
Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase.
Neurodegenerative Diseases
Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii.
Neurodegenerative Diseases
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Neurodegenerative Diseases
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Neurodegenerative Diseases
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Neuroinflammatory Diseases
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Neuroinflammatory Diseases
Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.
Neuroinflammatory Diseases
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
Neuroinflammatory Diseases
Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.
Neuroinflammatory Diseases
[Realgar is active ingredient of Angong Niuhuang pill in protection against LPS-induced neuroinflammation].
Obesity
Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Obesity
Peripheral kynurenine-3-monooxygenase deficiency as a potential risk factor for metabolic syndrome in schizophrenia patients.
Obesity
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Ototoxicity
Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na(+)/K(+)-ATPase activities.
Pancreatitis
Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers.
Pancreatitis
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Pancreatitis
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.
Pancreatitis
Kynurenine Monooxygenase (KMO) Inhibitors for the Treatment of Acute Pancreatitis and Neurodegenerative Disorders.
Pancreatitis
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Pancreatitis
Pancreatitis: KMO inhibitor for multi-organ failure in experimental acute pancreatitis.
Pancreatitis
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Pancreatitis
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Parkinson Disease
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys.
Parkinson Disease
Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites.
Persistent Infection
Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight.
Pneumoconiosis
[On the problem of the combined effect of cinnabar and mercury vapor on the development of pneumoconiosis in experimental animals]
Reperfusion Injury
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
Reperfusion Injury
Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.
Sexually Transmitted Diseases
[Mercury--a major agent in the history of medicine and alchemy]
Sleep Initiation and Maintenance Disorders
Evaluating the spectrum-effect profiling and pharmacokinetics of Tieshuang Anshen Prescription with better sedative-hypnotic effect based on Fe2+ than Hg2.
Spasm
A Gift from the Buddhist Monastery: The Role of Buddhist Medical Practices in the Assimilation of the Opium Poppy in Chinese Medicine during the Song Dynasty (960-1279).
Starvation
Cinnabar protects serum-nutrient starvation induced apoptosis by improving intracellular oxidative stress and inhibiting the expression of CHOP and PERK.
Stroke
Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide.
Triple Negative Breast Neoplasms
Kynurenine 3-monooxygenase upregulates pluripotent genes through ?-catenin and promotes triple-negative breast cancer progression.
Triple Negative Breast Neoplasms
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.
Trypanosomiasis, African
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
Virus Diseases
Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
Virus Diseases
Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight.
Yellow Fever
Analysis of the wild-type and mutant genes encoding the enzyme kynurenine monooxygenase of the yellow fever mosquito, Aedes aegypti.
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