Information on EC 1.14.13.57 - dihydrochelirubine 12-monooxygenase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
1.14.13.57
-
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RECOMMENDED NAME
GeneOntology No.
dihydrochelirubine 12-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydrochelirubine + NADPH + H+ + O2 = 12-hydroxydihydrochelirubine + NADP+ + H2O
show the reaction diagram
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sanguinarine and macarpine biosynthesis
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Isoquinoline alkaloid biosynthesis
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Metabolic pathways
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)
A heme-thiolate protein (P-450)
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CAS REGISTRY NUMBER
COMMENTARY hide
158736-41-5
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Thalictrum bulgaricum
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dihydrochelirubine + NADH + O2
12-hydroxydihydrochelirubine + NAD+
show the reaction diagram
Thalictrum bulgaricum
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at 83% of the activity with NADPH
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-
dihydrochelirubine + NADPH + O2
12-hydroxydihydrochelirubine + NADP+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dihydrochelirubine + NADPH + O2
12-hydroxydihydrochelirubine + NADP+
show the reaction diagram
Thalictrum bulgaricum
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involved the penultimate step in the biosynthesis of macarpine, the most highly oxidized benzophenanthridine alkaloid found in nature
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-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
Thalictrum bulgaricum
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dependent on
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NADH
Thalictrum bulgaricum
-
dependent on NADPH or NADH
NADPH
Thalictrum bulgaricum
-
dependent on NADPH or NADH
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Methyl-1,2-di(3-pyridyl)-1-propanone
Thalictrum bulgaricum
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i.e. methyrapone
5-hydroxy-1,4-naphthoquinone
Thalictrum bulgaricum
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i.e. juglone
CO
Thalictrum bulgaricum
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inhibition in the dark, effect is partly reversible upon illumination
cytochrome c
Thalictrum bulgaricum
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-
ketoconazole
Thalictrum bulgaricum
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-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.5
Thalictrum bulgaricum
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-
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
Thalictrum bulgaricum
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-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Thalictrum bulgaricum
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yeast-elicited cells
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Thalictrum bulgaricum
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associated with
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Manually annotated by BRENDA team
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.57)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)