Reference on EC 1.14.13.39 - nitric-oxide synthase (NADPH)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Knowles, R.G.; Merrett, M.; Salter, M.; Moncada, S.
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
Biochem. J.
270
833-836
1990
Rattus norvegicus, Rattus norvegicus Wistar
Bredt, D.S.; Snyder, S.H.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
Proc. Natl. Acad. Sci. USA
87
682-685
1990
Rattus norvegicus
Stuehr, D.J.; Ikeda-Saito, M.
Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical
J. Biol. Chem.
267
20547-20550
1992
Mus musculus, Rattus norvegicus
Pufahl, R.A.; Nanjappan, P.G.; Woodard, R.W.; Marletta, M.A.
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages
Biochemistry
31
6822-6828
1992
Mus musculus
Klatt, P.; Heinzel, B.; Mayer, B.; Ambach, E.; Werner-Felmayer, G.; Wachter, H.; Werner, E.R.
Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor
FEBS Lett.
305
160-162
1992
Homo sapiens
Hevel, J.M.; Marletta, M.A.
Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity
Biochemistry
31
7160-7165
1992
Mus musculus
Schmidt, H.H.H.W.; Smith, R.M.; Nakane, M.; Murad, F.
Ca2+/calmodulin-dependent NO synthase type I: a biopteroflavoprotein with Ca2+/calmodulin-independent diaphorase and reductase activities
Biochemistry
31
3243-3249
1992
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Bush, P.A.; Gonzalez, N.E.; Griscavage, J.M.; Ignarro, L.J.
Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine
Biochem. Biophys. Res. Commun.
185
960-966
1992
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
White, K.A.; Marletta, M.A.
Nitric oxide synthase is a cytochrome P-450 type hemoprotein
Biochemistry
31
6627-6631
1992
Mus musculus, Rattus norvegicus
Klatt, P.; Heinzel, B.; John, M.; Kastner, M.; Bhme, E.; Mayer, B.
Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase
J. Biol. Chem.
267
11374-11378
1992
Sus scrofa
Xie, Q.W.; Hearn, J.C.; Calaycay, J.; Mumford, R.A.; Swiderek, K.M.; Lee, T.D.; Ding, A.; Troso, T.; Nathan, C.
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
Science
256
225-228
1992
Mus musculus
Stuehr, D.J.; Cho, H.J.; Kwon, N.S.; Weise, M.F.; Nathan, C.F.
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein
Proc. Natl. Acad. Sci. USA
88
7773-7777
1991
Mus musculus
Hiki, K.; Hattori, R.; Kawai, C.; Yui, Y.
Purification of insoluble nitric oxide synthase from rat cerebellum
J. Biochem.
111
556-558
1992
Rattus norvegicus, Rattus norvegicus Wistar
Ohshima, H.; Oguchi, S.; Adachi, H.; Iida, S.; Suzuki, H.; Sugimura, T.; Esumi, H.
Purification of nitric oxide synthase from bovine brain: immunological characterization and tissue distribution
Biochem. Biophys. Res. Commun.
183
238-244
1992
Bos taurus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Hecker, M.; Walsh, D.T.; Vane, J.R.
On the substrate specificity of nitric oxide synthase
FEBS Lett.
294
221-224
1991
Bos taurus, Mus musculus
Schmidt, H.H.H.W.; Murad, F.
Purification and characterization of a human NO synthase
Biochem. Biophys. Res. Commun.
181
1372-1377
1991
Homo sapiens
Hevel, J.M.; White, K.A.; Marletta, M.A.
Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein
J. Biol. Chem.
266
22789-22791
1991
Mus musculus
Yui, Y.; Hattori, R.; Kosuga, K.; Eizawa, H.;Hiki, K.; Kawai, C.
Purification of nitric oxide synthase from rat macrophages
J. Biol. Chem.
266
12544-12547
1991
Rattus norvegicus
Yui, Y.; Hattori, R.; Kosuga, K.; Eizawa, H.;Hiki, K.; Ohkawa, S.; Ohnishi, K.; Terao, S.; Kawai, C.
Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils
J. Biol. Chem.
266
3369-3371
1991
Rattus norvegicus
Stuehr, D.J.; Fasehun, O.A.; Kwon, N.S.; Gross, S.S.; Gonzalez, J.A.; Levi, R.; Nathan, C.F.
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs
FASEB J.
5
98-103
1991
Mus musculus
Knowles, R.G.; Palacios, M.; Palmer, R.M.J.; Moncada, S.
Kinetic characteristics of nitric oxide synthase from rat brain
Biochem. J.
269
207-210
1990
Rattus norvegicus
Mayer, B.; John, M.; Bhme, E.
Purification of a Ca2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin
FEBS Lett.
277
215-219
1990
Sus scrofa
Murphy, M.
Kinetic characteristics of nitric oxide synthase from rat brain
Biochem. J.
271
563-564
1990
Rattus norvegicus
Kosuga, K.; Yui, Y.; Hattori, R.; Eizawa, H.;Hiki, K.; Kawai, C.
Stabilizing factor(s) of nitric oxide (NO) synthetase
Biochem. Biophys. Res. Commun.
172
705-708
1990
Rattus norvegicus
Wolff, D.J.; Datto, G.A.
Identification and characterization of a calmodulin-dependent nitric oxide synthase from GH3 pituitary cells
Biochem. J.
285
201-206
1992
Bos taurus
Werner-Felmayer, G.; Werner, E.R.; Fuchs, D.; Hausen, A.; Mayer, B.; Reibnegger, G.; Weiss, G.; Wachter, H.
Calcium/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180
Biochem. J.
289
357-361
1993
Homo sapiens
-
Leber, A.; Hemmens, B.; Klosch, B.; Goessler, W.; Raber, G.; Mayer, B.; Schmidt, K.
Characterization of recombinant human endothelial nitric-oxide synthase purified from the yeast Pichia pastoris
J. Biol. Chem.
274
37658-37664
1999
Homo sapiens
Iwasaki, T.; Hori, H.; Hayashi, Y.; Nishino, T.; Tamura, K.; Oue, S.; Iizuka, T.; Ogura, T.; Esumi, H.
Characterization of mouse nNOS2, a natural variant of neuronal nitric-oxide synthase produced in the central nervous system by selective alternative splicing
J. Biol. Chem.
274
17559-17566
1999
Mus musculus
Xia, Y.; Tsai, A.L.; Berka, V.; Zweier, J.L.
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
J. Biol. Chem.
273
25804-25808
1998
Homo sapiens
McMillan, K.; Adler, M.; Auld, D.S.; Baldwin, J.J.; Blasko, E.; Browne, L.J.; Chelsky, D.; Davey, D.; Dolle, R.E.; Eagen, K.A.; Erickson, S.; Feldman, R.I.; Glaser, C.B.; Mallari, C.; Morrissey, M.M.; Ohlmeyer, M.H.J.; Pan, G.; Parkinson, J.F.; Phillips, G.B.; Polokoff, M.A.; Sigal, N.H.; Vergona, R.; Whitlow, M.; Young, T.A.; Devlin, J.J
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
Proc. Natl. Acad. Sci. USA
97
1506-1511
2000
Homo sapiens, Mus musculus (P29477), Mus musculus
Campos, K.L.; Giovanelli, J.; Kaufman, S.
Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide
J. Biol. Chem.
270
1721-1728
1995
Rattus norvegicus
Siddhanta, U.; Wu, C.; Abu-Soud, H.M.; Zhang, J.; Ghosh, D.K.; Stuehr, D.J.
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains
J. Biol. Chem.
271
7309-7312
1996
Mus musculus
Rusche, K.M.; Spiering, M.M.; Marletta, M.A.
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase
Biochemistry
37
15503-15512
1998
Mus musculus
Baek, K.J.; Thiel, B.A.; Lucas, S.; Stuehr, D.J.
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme
J. Biol. Chem.
268
21120-21129
1993
Mus musculus
Cote, J.F.; Roberge, A.G.
Nitric oxide synthase in cat brain: cofactors - enzyme-substrate interaction
Free Radic. Biol. Med.
21
109-115
1996
Felis catus
Ghosh, D.K.; Stuehr, D.J.
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction
Biochemistry
34
801-807
1995
Mus musculus
Foerstermann, U.; Closs, E.I.; Pollock, J.S.; Nakane, M.; Schwarz, P.; Gath, I.; Kleinert, H.
Nitric oxide synthase isoenzymes. Characterization, purification, molecular cloning, and functions
Hypertension
23
1121-1131
1994
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Nam, S.W.; Seo, D.W.; Sung, D.S.; Han, J.W.; Hong, S.Y.; Lee, H.W.
Nitric oxide synthase from bovine pancreas: purification and characterization
Arch. Pharm. Res.
21
128-134
1998
Bos taurus
Mittal, C.K.; Jadhav, A.L.
Calcium-dependent inhibition of constitutive nitric oxide synthase
Biochem. Biophys. Res. Commun.
203
8-15
1994
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Wever, R.M.F.; Van Dam, T.; Van Rijn, H.J.M.; De Groot, F.; Rabelink, T.J.
Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
Biochem. Biophys. Res. Commun.
237
340-344
1997
Bos taurus
Conrad, K.P.; Powers, R.W.; Davis, A.K.; Novak, J.
Citrulline is not the major product using the standard NOS activity assay on renal cortical homogenates
Am. J. Physiol.
282
R303-R310
2002
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Garcia-Pascual, A.; Costa, G.; Labadia, A.; Persson, K.; Triguero, D.
Characterization of nitric oxide synthase activity in sheep urinary tract: functional implications
Br. J. Pharmacol.
118
905-914
1996
Ovis aries
Sheng, H.; Ignarro, L.J.
Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina
Pharm. Res.
33
29-34
1996
Rattus norvegicus, Rattus norvegicus Wistar
Demady, D.R.; Jianmongkol, S.; Vuletich, J.L.; Bender, A.T.; Osawa, Y.
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme
Mol. Pharmacol.
59
24-29
2001
Homo sapiens
Richards, M.K.; Clague, M.J.; Marletta, M.A.
Characterization of C415 mutants of neuronal nitric oxide synthase
Biochemistry
35
7772-7780
1996
Mus musculus
Wolff, D.J.; Lubeskie, A.; Umansky, S.
The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents
Arch. Biochem. Biophys.
314
360-366
1994
Bos taurus
Reif, D.W.; McCreedy, S.A.
N-Nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases
Arch. Biochem. Biophys.
320
170-176
1995
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Gerber, N.C.; Nishida, C.R.; de Montellano, P.R.O.
Characterization of human liver inducible nitric oxide synthase expressed in Escherichia coli
Arch. Biochem. Biophys.
343
249-253
1997
Homo sapiens
Abu-Soud, H.M.; Loftus, M.; Stuehr, D.J.
Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function
Biochemistry
34
11167-11175
1995
Mus musculus
Lacza, Z.; Puskar, M.; Figueroa, J.P.; Zhang, J.; Rajapakse, N.; Busija, D.W.
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia
Free Radic. Biol. Med.
31
1609-1615
2001
Mus musculus, Mus musculus C57BL/6
Presta, A.; Liu, J.; Sessa, W.C.; Stuehr, D.J.
Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymic activity
Nitric Oxide
1
74-87
1997
Bos taurus
Fu, J.; Yamamoto, K.; Guan, Z.W.; Kimura, S.; Iyanagi, T.
Human neuronal nitric oxide synthase can catalyze one-electron reduction of adriamycin: role of flavin domain
Arch. Biochem. Biophys.
427
180-187
2004
Homo sapiens
Sengupta, R.; Sahoo, R.; Mukherjee, S.; Regulski, M.; Tully, T.; Stuehr, D.J.; Ghosh, S.
Characterization of Drosophila nitric oxide synthase: a biochemical study
Biochem. Biophys. Res. Commun.
306
590-597
2003
Drosophila melanogaster
Ingledew, W.J.; Smith, S.M.; Gao, Y.T.; Jones, R.J.; Salerno, J.C.; Rich, P.R.
Ligand, cofactor, and residue vibrations in the catalytic site of endothelial nitric oxide synthase
Biochemistry
44
4238-4246
2005
Bos taurus (P29473), Bos taurus
Wang, Z.Q.; Wei, C.C.; Santolini, J.; Panda, K.; Wang, Q.; Stuehr, D.J.
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms
Biochemistry
44
4676-4690
2005
Rattus norvegicus, Mus musculus (P29477), Mus musculus
Chandok, M.R.; Ytterberg, A.J.; van Wijk, K.J.; Klessig, D.F.
The pathogen-inducible nitric oxide synthase (iNOS) in plants is a variant of the P protein of the glycine decarboxylase complex
Cell
113
469-482
2003
Nicotiana tabacum
Hernandez-Campos, M.E.; Campos-Rodriguez, R.; Tsutsumi, V.; Shibayama, M.; Garcia-Latorre, E.; Castillo-Henkel, C.; Valencia-Hernandez, I.
Nitric oxide synthase in Entamoeba histolytica: its effect on rat aortic rings
Exp. Parasitol.
104
87-95
2003
Entamoeba histolytica
Hong, I.S.; Kim, Y.K.; Choi, W.S.; Seo, D.W.; Yoon, J.W.; Han, J.W.; Lee, H.Y.; Lee, H.W.
Purification and characterization of nitric oxide synthase from Staphylococcus aureus
FEMS Microbiol. Lett.
222
177-182
2003
Staphylococcus aureus
Lacza, Z.; Snipes, J.A.; Zhang, J.; Horvath, E.M.; Figueroa, J.P.; Szabo, C.; Busija, D.W.
Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS
Free Radic. Biol. Med.
35
1217-1228
2003
Mus musculus
Panda, K.; Adak, S.; Aulak, K.S.; Santolini, J.; McDonald, J.F.; Stuehr, D.J.
Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis
J. Biol. Chem.
278
37122-37131
2003
Rattus norvegicus
Panda, K.; Adak, S.; Konas, D.; Sharma, M.; Stuehr, D.J.
A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis
J. Biol. Chem.
279
18323-18333
2004
Rattus norvegicus
Wang, Z.Q.; Wei, C.C.; Sharma, M.; Pant, K.; Crane, B.R.; Stuehr, D.J.
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles
J. Biol. Chem.
279
19018-19025
2004
Bacillus subtilis, Bacillus subtilis (O34453), Mus musculus (P29477), Mus musculus, Bacillus subtilis 168 (O34453)
Moreau, M.; Takahashi, H.; Sari, M.A.; Boucher, J.L.; Sagami, I.; Shimizu, T.; Mansuy, D.
Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase
J. Inorg. Biochem.
98
1200-1209
2004
Rattus norvegicus (P29476)
Bodnarova, M.; Martasek, P.; Moroz, L.L.
Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: biochemical characterization and link to cGMP pathways
J. Inorg. Biochem.
99
922-928
2005
Aplysia californica
Golser, R.; Gorren, A.C.; Mayer, B.; Schmidt, K.
Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system
Nitric Oxide
8
7-14
2003
Homo sapiens
Fedorov, R.; Vasan, R.; Ghosh, D.K.; Schlichting, I.
Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design
Proc. Natl. Acad. Sci. USA
101
5892-5897
2004
Homo sapiens, Rattus norvegicus (P29476), Mus musculus (P29477), Mus musculus
Enkhbaatar, P.; Murakami, K.; Shimoda, K.; Mizutani, A.; McGuire, R.; Schmalstieg, F.; Cox, R.; Hawkins, H.; Jodoin, J.; Lee, S.; Traber, L.; Herndon, D.; Traber, D.
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model
Am. J. Physiol.
285
R366-372
2003
Homo sapiens
Dowling, R.B.; Newton, R.; Robichaud, A.; Cole, P.J.; Barnes, P.J.; Wilson, R.
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro
Am. J. Respir. Cell Mol. Biol.
19
950-958
1998
Homo sapiens
Er, H.; Turkoz, Y.; Ozerol, I.H.; Uzmez, E.
Effect of nitric oxide synthase inhibition in experimental Pseudomonas keratitis in rabbits
Eur. J. Ophthalmol.
8
137-141
1998
Oryctolagus cuniculus
Calderon-Cortes, E.; Clemente-Guerrero, M.; Sierra-Campos, E.; Cortes-Rojo, C.; Gaona-Zamudio, F.J.; Villalobos-Molina, R.; Saavedra-Molina, A.
Functional characterization of brain mitochondrial nitric oxide synthase during hypertension and aging
Amino Acids
30
73-80
2006
Rattus norvegicus
Genestra, M.; Guedes-Silva, D.; Souza, W.J.; Cysne-Finkelstein, L.; Soares-Bezerra, R.J.; Monteiro, F.P.; Leon, L.L.
Nitric oxide synthase (NOS) characterization in Leishmania amazonensis axenic amastigotes
Arch. Med. Res.
37
328-333
2006
Leishmania amazonensis
Midha, S.; Mishra, R.; Aziz, M.A.; Sharma, M.; Mishra, A.; Khandelwal, P.; Bhatnagar, R.
Cloning, expression, and characterization of recombinant nitric oxide synthase-like protein from Bacillus anthracis
Biochem. Biophys. Res. Commun.
336
346-356
2005
Bacillus anthracis
Marchal, S.; Gorren, A.C.; Andersson, K.K.; Lange, R.
Hunting oxygen complexes of nitric oxide synthase at low temperature and high pressure
Biochem. Biophys. Res. Commun.
338
529-535
2005
Homo sapiens, Rattus norvegicus
Wilson, D.J.; Rafferty, S.P.; Konermann, L.
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry
Biochemistry
44
2276-2283
2005
Mus musculus
Xia, Y.; Berlowitz, C.O.; Zweier, J.L.
PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase
Biochim. Biophys. Acta
1760
1445-1449
2006
Rattus norvegicus
Jackson, S.A.; Sahni, S.; Lee, L.; Luo, Y.; Nieduzak, T.R.; Liang, G.; Chiang, Y.; Collar, N.; Fink, D.; He, W.; Laoui, A.; Merrill, J.; Boffey, R.; Crackett, P.; Rees, B.; Wong, M.; Guilloteau, J.P.; Mathieu, M.; Rebello, S.S.
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase
Bioorg. Med. Chem.
13
2723-2739
2005
Homo sapiens, Rattus norvegicus, Mus musculus (P29477), Mus musculus
Soto, I.; Lopez-Roca, T.; Blagburn, J.M.; Blanco, R.E.
Changes in nNOS and NADPH diaphorase in frog retina and tectum after axotomy and FGF-2 application
Brain Res.
1103
65-75
2006
Lithobates pipiens
Fish, J.E.; Marsden, P.A.
Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium
Cell. Mol. Life Sci.
63
144-162
2006
Homo sapiens
Zemojtel, T.; Kolanczyk, M.; Kossler, N.; Stricker, S.; Lurz, R.; Mikula, I.; Duchniewicz, M.; Schuelke, M.; Ghafourifar, P.; Martasek, P.; Vingron, M.; Mundlos, S.
Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate
FEBS Lett.
580(2)
455-462
2006
Mus musculus
Lemaire, J.F.; McPherson, P.S.
Binding of Vac14 to neuronal nitric oxide synthase: characterisation of a new internal PDZ-recognition motif
FEBS Lett.
580
6948-6954
2006
Homo sapiens
Chen, K.; Popel, A.S.
Vascular and perivascular nitric oxide release and transport: Biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)
Free Radic. Biol. Med.
42
811-822
2007
Homo sapiens
Acharya, K.; Yonzone, P.; Rai, M.; Rupa, A.
Antioxidant and nitric oxide synthase activation properties of Ganoderma applanatum
Indian J. Exp. Biol.
43
926-929
2005
Ganoderma applanatum
Fish, J.E.; Matouk, C.C.; Rachlis, A.; Lin, S.; Tai, S.C.; DAbreo, C.; Marsden, P.A.
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code
J. Biol. Chem.
280
24824-24838
2005
Homo sapiens
Ghosh, D.K.; Holliday, M.A.; Thomas, C.; Weinberg, J.B.; Smith, S.M.; Salerno, J.C.
Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs
J. Biol. Chem.
281
14173-14183
2006
Mus musculus, Homo sapiens (P29474), Rattus norvegicus (P29476)
Saini, R.; Patel, S.; Saluja, R.; Sahasrabuddhe, A.A.; Singh, M.P.; Habib, S.; Bajpai, V.K.; Dikshit, M.
Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies
J. Leukoc. Biol.
79
519-528
2006
Rattus norvegicus
Ishii, H.; Shibuya, K.; Ohta, Y.; Mukai, H.; Uchino, S.; Takata, N.; Rose, J.A.; Kawato, S.
Enhancement of nitric oxide production by association of nitric oxide synthase with N-methyl-D-aspartate receptors via postsynaptic density 95 in genetically engineered Chinese hamster ovary cells: real-time fluorescence imaging using nitric oxide sensiti
J. Neurochem.
96
1531-1539
2006
Cricetulus griseus
Wei, C.L.; Hon, W.M.; Lee, K.H.; Khoo, H.E.
Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis
World J. Gastroenterol.
11
362-367
2005
Rattus norvegicus (Q06518)
Karmohapatra, S.K.; Chakraborty, K.; Kahn, N.N.; Sinha, A.K.
The role of nitric oxide in aspirin induced thrombolysis in vitro and the purification of aspirin activated nitric oxide synthase from human blood platelets
Am. J. Hematol.
82
986-995
2007
Homo sapiens
Krieglstein, C.F.; Anthoni, C.; Cerwinka, W.H.; Stokes, K.Y.; Russell, J.; Grisham, M.B.; Granger, D.N.
Role of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation
Am. J. Pathol.
170
490-496
2007
Mus musculus
Chartier, F.J.; Couture, M.
Interactions between substrates and the haem-bound nitric oxide of ferric and ferrous bacterial nitric oxide synthases
Biochem. J.
401
235-245
2007
Bacillus subtilis, Staphylococcus aureus
Ray, S.S.; Tejero, J.; Wang, Z.Q.; Dutta, T.; Bhattacharjee, A.; Regulski, M.; Tully, T.; Ghosh, S.; Stuehr, D.J.
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release
Biochemistry
46
11857-11864
2007
Drosophila melanogaster
Ray, S.S.; Sengupta, R.; Tiso, M.; Haque, M.M.; Sahoo, R.; Konas, D.W.; Aulak, K.; Regulski, M.; Tully, T.; Stuehr, D.J.; Ghosh, S.
Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues
Biochemistry
46
11865-11873
2007
Drosophila melanogaster
Tiso, M.; Tejero, J.; Panda, K.; Aulak, K.S.; Stuehr, D.J.
Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail
Biochemistry
46
14418-14428
2007
Rattus norvegicus
Tirapelli, C.R.; Fukada, S.Y.; Yogi, A.; Chignalia, A.Z.; Tostes, R.C.; Bonaventura, D.; Lanchote, V.L.; Cunha, F.Q.; de Oliveira, A.M.
Gender-specific vascular effects elicited by chronic ethanol consumption in rats: a role for inducible nitric oxide synthase
Br. J. Pharmacol.
153
468-479
2008
Rattus norvegicus
Settembrini, B.P.; Coronel, M.F.; Nowicki, S.; Nighorn, A.J.; Villar, M.J.
Distribution and characterization of nitric oxide synthase in the nervous system of Triatoma infestans (Insecta: Heteroptera)
Cell Tissue Res.
328
421-430
2007
Triatoma infestans
Langnaese, K.; Richter, K.; Smalla, K.H.; Krauss, M.; Thomas, U.; Wolf, G.; Laube, G.
Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSalpha beta-finger is largely exposed to antibodies
Dev. Neurobiol.
67
422-437
2007
Mus musculus, Rattus norvegicus
Li, D.; Kabir, M.; Stuehr, D.J.; Rousseau, D.L.; Yeh, S.R.
Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase
J. Am. Chem. Soc.
129
6943-6951
2007
Mus musculus
Wang, W.S.; Hung, S.W.; Lin, Y.H.; Tu, C.Y.; Wong, M.L.; Chiou, S.H.; Shieh, M.T.
Purification and localization of nitric oxide synthases from hybrid tilapia (Nile tilapia x Mozambique tilapia)
J. Aquat. Anim. Health
19
168-178
2007
Oreochromis mossambicus x niloticus
Marechal, A.; Mattioli, T.A.; Stuehr, D.J.; Santolini, J.
Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress
J. Biol. Chem.
282
14101-14112
2007
Mus musculus
Chartier, F.J.; Couture, M.
Substrate-specific interactions with the heme-bound oxygen molecule of nitric-oxide synthase
J. Biol. Chem.
282
20877-20886
2007
Bacillus subtilis, Staphylococcus aureus
Wang, Z.; Lawson, R.J.; Buddha, M.R.; Wei, C.; Crane, B.R.; Munro, A.W.; Stuehr, D.J.
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase
J. Biol. Chem.
282
2196-2202
2007
Bacillus subtilis
Gao, Y.T.; Roman, L.J.; Martasek, P.; Panda, S.P.; Ishimura, Y.; Masters, B.S.
Oxygen metabolism by endothelial nitric-oxide synthase
J. Biol. Chem.
282
28557-28565
2007
Rattus norvegicus
Wei, C.C.; Wang, Z.Q.; Tejero, J.; Yang, Y.P.; Hemann, C.; Hille, R.; Stuehr, D.J.
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase
J. Biol. Chem.
283
11734-11742
2008
Rattus norvegicus (P29476)
Gusarov, I.; Starodubtseva, M.; Wang, Z.Q.; McQuade, L.; Lippard, S.J.; Stuehr, D.J.; Nudler, E.
Bacterial nitric-oxide synthases operate without a dedicated redox partner
J. Biol. Chem.
283
13140-13147
2008
Bacillus anthracis, Bacillus subtilis
Huang, D.; Cai, D.T.; Chua, R.Y.; Kemeny, D.M.; Wong, S.H.
Nitric-oxide synthase 2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development
J. Biol. Chem.
283
1713-1722
2008
Mus musculus
Ilagan, R.P.; Tiso, M.; Konas, D.W.; Hemann, C.; Durra, D.; Hille, R.; Stuehr, D.J.
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins
J. Biol. Chem.
283
19603-19615
2008
Bos taurus
Carrier, E.; Brochu, I.; de Brum-Fernandes, A.J.; DOrleans-Juste, P.
The inducible nitric-oxide synthase modulates endothelin-1-dependent release of prostacyclin and inhibition of platelet aggregation ex vivo in the mouse
J. Pharmacol. Exp. Ther.
323
972-978
2007
Mus musculus
Widdison, S.; Ashley, G.R.; Howard, C.J.; Coffey, T.J.
Characterisation of bovine inducible nitric oxide synthase
Vet. Immunol. Immunopathol.
117
302-309
2007
Bos taurus (Q9BDQ7), Bos taurus
Moreno, J.A.; Sullivan, K.A.; Carbone, D.L.; Hanneman, W.H.; Tjalkens, R.B.
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways
J. Neurosci. Res.
86
2028-2038
2008
Mus musculus (P29477)
Oktem, G.; Altay, B.; Turna, B.; Aktug, H.; Yavasoglu, A.; Yilmaz, O.; Semerci, B.
Determination of nitric oxide synthase activity and apoptosis of germ cells in different obstruction models
Acta Histochem.
111
119-126
2009
Rattus norvegicus (Q06518), Rattus norvegicus (Q62600), Rattus norvegicus
Brindicci, C.; Kharitonov, S.A.; Ito, M.; Elliott, M.W.; Hogg, J.C.; Barnes, P.J.; Ito, K.
Nitric oxide synthase isoenzyme expression and activity in peripheral lungs of COPD patients
Am. J. Respir. Crit. Care Med.
181
21-30
2009
Homo sapiens (P29474), Homo sapiens (P29475), Homo sapiens (P35228), Homo sapiens
Kim, J.; Park, H.; Myung-Hyun, J.; Han, S.H.; Chung, H.; Lee, J.S.; Park, J.S.; Yoon, M.Y.
The effects of anthrax lethal factor on the macrophage proteome: potential activity on nitric oxide synthases
Arch. Biochem. Biophys.
472
58-64
2008
Rattus norvegicus (P29476), Rattus norvegicus (Q06518)
Mikula, I.; Durocher, S.; Martasek, P.; Mutus, B.; Slama-Schwok, A.
Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia
Biochem. J.
418
673-682
2009
Homo sapiens, Homo sapiens (P29474), Homo sapiens (P29475)
Tran, Q.K.; Leonard, J.; Black, D.J.; Persechini, A.
Phosphorylation within an autoinhibitory domain in endothelial nitric oxide synthase reduces the Ca2+ concentrations required for calmodulin to bind and activate the enzyme
Biochemistry
47
7557-7566
2008
Bos taurus (P29473), Bos taurus
Lee, Y.Z.; Yang, C.W.; Kang, I.J.; Wu, S.H.; Chao, Y.S.; Chern, J.H.; Lee, S.J.
Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma
Bioorg. Med. Chem. Lett.
18
5676-5679
2008
Mus musculus
Heesch, C.M.; Zheng, H.; Foley, C.M.; Mueller, P.J.; Hasser, E.M.; Patel, K.P.
Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats
Brain Res.
1251
140-150
2009
Rattus norvegicus (P29476)
Sullivan, J.; Smart, E.; Pollock, D.; Pollock, J.
Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla
Clin. Exp. Pharmacol. Physiol.
35
120-125
2008
Rattus norvegicus (P29476), Rattus norvegicus (Q62600)
Lenasi, H.; Strucl, M.
The effect of nitric oxide synthase and cyclooxygenase inhibition on cutaneous microvascular reactivity
Eur. J. Appl. Physiol.
103
719-726
2008
Homo sapiens (P29474), Homo sapiens
Schmidt, A.; Bilgasem, S.; Lorkowski, S.; Vischer, P.; Voelker, W.; Breithardt, G.; Siegel, G.; Buddecke, E.
Exogenous nitric oxide regulates activity and synthesis of vascular endothelial nitric oxide synthase
Eur. J. Clin. Invest.
38
476-485
2008
Homo sapiens
Lu, L.; Shimizu, T.; Nakamura, K.; Yokotani, K.
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats
Eur. J. Pharmacol.
590
177-184
2008
Rattus norvegicus
Minardi, D.; Ghiselli, R.; Lucarini, G.; Mocchegiani, F.; Filosa, A.; Zizzi, A.; Simonetti, O.; Orlando, F.; Pelliccioni, G.; Parri, G.; Saba, V.; Lo Muzio, L.; Biagini, G.; Montironi, R.; Muzzonigro, G.
Activity and expression of nitric oxide synthase in rat bladder after sacral neuromodulation
Int. J. Immunopathol. Pharmacol.
21
129-135
2008
Rattus norvegicus (P29476), Rattus norvegicus (Q06518)
de Visser, S.P.; Tan, L.S.
Is the bound substrate in nitric oxide synthase protonated or neutral and what is the active oxidant that performs substrate hydroxylation?
J. Am. Chem. Soc.
130
12961-12974
2008
Homo sapiens
Sabat, J.; Stuehr, D.J.; Yeh, S.R.; Rousseau, D.L.
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase
J. Am. Chem. Soc.
131
12186-12192
2009
Rattus norvegicus (Q06518)
Li, H.; Das, A.; Sibhatu, H.; Jamal, J.; Sligar, S.G.; Poulos, T.L.
Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential
J. Biol. Chem.
283
34762-34772
2008
Rattus norvegicus (P29476)
Tran, Q.K.; Leonard, J.; Black, D.J.; Nadeau, O.W.; Boulatnikov, I.G.; Persechini, A.
Effects of combined phosphorylation at Ser-617 and Ser-1179 in endothelial nitric-oxide synthase on EC50(Ca2+) values for calmodulin binding and enzyme activation
J. Biol. Chem.
284
11892-11899
2009
Bos taurus (P29473)
Wang, X.; Zhao, Q.; Matta, R.; Meng, X.; Liu, X.; Liu, C.G.; Nelin, L.D.; Liu, Y.
Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1
J. Biol. Chem.
284
27123-27134
2009
Mus musculus (P29477)
Nishida, C.R.; Ortiz de Montellano, P.R.
Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase
J. Med. Chem.
51
5118-5120
2008
Homo sapiens (P35228)
Igarashi, J.; Li, H.; Jamal, J.; Ji, H.; Fang, J.; Lawton, G.R.; Silverman, R.B.; Poulos, T.L.
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors
J. Med. Chem.
52
2060-2066
2009
Homo sapiens (P29474), Homo sapiens (P29475)
Cantoni, O.; Palomba, L.; Persichini, T.; Mariotto, S.; Suzuki, H.; Colasanti, M.
Pivotal role of arachidonic acid in the regulation of neuronal nitric oxide synthase activity and inducible nitric oxide synthase expression in activated astrocytes
Methods Enzymol.
440
243-252
2008
Rattus norvegicus (P29476)
Ghafourifar, P.; Parihar, M.S.; Nazarewicz, R.; Zenebe, W.J.; Parihar, A.
Detection assays for determination of mitochondrial nitric oxide synthase activity; advantages and limitations
Methods Enzymol.
440
317-334
2008
Rattus norvegicus
Aquilano, K.; Baldelli, S.; Rotilio, G.; Ciriolo, M.R.
Role of nitric oxide synthases in Parkinsons disease: a review on the antioxidant and anti-inflammatory activity of polyphenols
Neurochem. Res.
33
2416-2426
2008
Homo sapiens, Homo sapiens (P29475), Homo sapiens (P35228)
Serfozo, Z.; Kiss, P.; Kukor, Z.; Lontay, B.; Palatka, K.; Varga, V.; Erdodi, F.; Elekes, K.
Thyroid hormones affect the level and activity of nitric oxide synthase in rat cerebral cortex during postnatal development
Neurochem. Res.
33
569-578
2008
Rattus norvegicus (P29476)
Rosa, S.C.; Judas, F.; Lopes, M.C.; Mendes, A.F.
Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide
Nitric Oxide
19
276-283
2008
Homo sapiens (P29475), Homo sapiens (P35228), Homo sapiens
Ibiza, S.; Perez-Rodriguez, A.; Ortega, A.; Martinez-Ruiz, A.; Barreiro, O.; Garcia-Dominguez, C.A.; Victor, V.M.; Esplugues, J.V.; Rojas, J.M.; Sanchez-Madrid, F.; Serrador, J.M.
Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
Proc. Natl. Acad. Sci. USA
105
10507-10512
2008
Homo sapiens (P29474)
Jin, B.Y.; Sartoretto, J.L.; Gladyshev, V.N.; Michel, T.
Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells
Proc. Natl. Acad. Sci. USA
106
17343-17348
2009
Mus musculus (P70313)
Dooley, A.; Low, S.Y.; Holmes, A.; Kidane, A.G.; Abraham, D.J.; Black, C.M.; Bruckdorfer, K.R.
Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis
Rheumatology
47
272-280
2008
Mus musculus (P70313), Mus musculus
Wu, G.; Bazer, F.W.; Davis, T.A.; Kim, S.W.; Li, P.; Marc Rhoads, J.; Carey Satterfield, M.; Smith, S.B.; Spencer, T.E.; Yin, Y.
Arginine metabolism and nutrition in growth, health and disease
Amino Acids
37
153-168
2009
Mammalia
Novaretti, N.; Padovan-Neto, F.E.; Tumas, V.; da-Silva, C.A.; Del Bel, E.A.
Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats
Braz. J. Med. Biol. Res.
43
1047-1053
2010
Rattus norvegicus, Rattus norvegicus Wistar
Vaughan, D.; Speed, J.; Medve, R.; Andrews, J.S.
Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers
Clin. Ther.
32
146-160
2010
Homo sapiens
Li, Y.; Zhou, X.; Wei, Q.W.; Huang, R.H.; Shi, F.X.
Cell-specific expression and immunolocalization of nitric oxide synthase isoforms and soluble guanylyl cyclase alpha and beta subunits in postnatal porcine uteri
Acta Histochem.
116
466-473
2013
Sus scrofa
Elyaderani, M.; Askar, A.; Rostami, M.; Aberomand, M.; Kheirollah, A.
In vitro kinetic study of purified nitric oxide synthase from sheep kidney
Biochem. Cell. Arch.
12
169-174
2012
Ovis aries
-
Saluja, R.; Jyoti, A.; Chatterjee, M.; Habib, S.; Verma, A.; Mitra, K.; Barthwal, M.K.; Bajpai, V.K.; Dikshit, M.
Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells
Biochim. Biophys. Acta
1813
1700-1707
2011
Homo sapiens
Watanabe, M.; Itoh, K.
Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1
Biochim. Biophys. Acta
1814
900-907
2011
Rattus norvegicus (P29476)
Li, W.; Chen, L.; Fan, W.; Feng, C.
Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteins
FEBS Lett.
586
159-162
2012
Homo sapiens
Li, W.; Fan, W.; Chen, L.; Elmore, B.O.; Piazza, M.; Guillemette, J.G.; Feng, C.
Role of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase
J. Biol. Inorg. Chem.
17
675-685
2012
Homo sapiens (P35228), Homo sapiens
Cioni, C.; Di Patti, M.C.; Venturini, G.; Modica, M.V.; Scarpa, F.; Oliverio, M.; Toni, M.
Cellular, biochemical, and molecular characterization of nitric oxide synthase expressed in the nervous system of the prosobranch Stramonita haemastoma (Gastropoda, Neogastropoda)
J. Comp. Neurol.
520
364-383
2012
Stramonita haemastoma (E1XU24), Stramonita haemastoma
Li, H.; Jamal, J.; Chreifi, G.; Venkatesh, V.; Abou-Ziab, H.; Poulos, T.L.
Dissecting the kinetics of the NADP(+)-FADH2 charge transfer complex and flavin semiquinones in neuronal nitric oxide synthase
J. Inorg. Biochem.
124
1-10
2013
Rattus norvegicus
Solt, Z.; Zsombok, A.; Pollak, E.; Molnar, L.
NADPH-diaphorase histochemistry selectively stains peripheral and central sensory structures of lumbricid earhworms
Acta Biol. Hung.
67
364-372
2016
Lumbricus terrestris, Eisenia fetida
Maisky, V.A.; Mankivska, O.P.; Maznychenko, A.V.; Vlasenko, O.V.; Dovgan, O.V.; Schomburg, E.D.; Steffens, H.
NADPH-diaphorase reactivity and Fos-immunoreactivity within the ventral horn of the lumbar spinal cord of cats submitted to acute muscle inflammation
Acta Histochem.
118
659-664
2016
Felis catus
Liu, C.; Yang, Y.; Hu, X.; Li, J.; Zhang, X.; Cai, Y.; Li, Z.; Yan, X.
Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex
Front. Neuroanat.
9
1-12
2015
Cavia porcellus
-
Hinova-Palova, D.; Edelstein, L.; Landzhov, B.; Minkov, M.; Malinova, L.; Hristov, S.; Denaro, F.; Alexandrov, A.; Kiriakova, T.; Brainova, I.; Paloff, A.; Ovtscharoff, W.
Topographical distribution and morphology of NADPH-diaphorase-stained neurons in the human claustrum
Front. Syst. Neurosci.
8
96
2014
Homo sapiens
-
Nacsa, K.; Elekes, K.; Serfozo, Z.
Ultrastructural localization of NADPH diaphorase and nitric oxide synthase in the neuropils of the snail CNS
Micron
75
58-66
2015
Helix pomatia, Lymnaea stagnalis, Lymnaea stagnalis (O61309)
Liman, N.; Alan, E.
Region-specific localization of NOS isoforms and NADPH-diaphorase activity in the intratesticular and excurrent duct systems of adult domestic cats (Felis catus)
Microsci. Res. Technol.
79
192-208
2016
Felis catus
Grassi, D.; Lagunas, N.; Pinos, H.; Panzica, G.; Garcia-Segura, L.M.; Collado, P.
NADPH-Diaphorase colocalizes with GPER and is modulated by the GPER agonist G1 in the supraoptic and paraventricular nuclei of ovariectomized female rats
Neuroendocrinology
104
94-104
2017
Rattus norvegicus
Chertok, V.; Kotsyuba, A.
Distribution of NADPH-diaphorase and neuronal NO synthase in the nuclei of the medulla oblongata in rats
Neurosci. Behav. Physiol.
44
909-913
2014
Rattus norvegicus
-
Grassi, D.; Lagunas, N.; Amorin, M.; Pinos, H.; Panzica, G.C.; Garcia-Segura, L.M.; Collado, P.
Estrogenic regulation of NADPH-diaphorase in the supraoptic and paraventricular nuclei under acute osmotic stress
Neuroscience
248
127-135
2013
Rattus norvegicus
Coburn, C.G.; Watson-Siriboe, A.; Hou, B.; Cheetham, C.; Gillard, E.R.; Lin, L.; Leon-Olea, M.; Sanchez-Islas, E.; Mucio-Ramirez, S.; Curras-Collazo, M.C.
Permanently compromised NADPH-diaphorase activity within the osmotically activated supraoptic nucleus after in utero but not adult exposure to Aroclor 1254
Neurotoxicology
47
37-46
2015
Rattus norvegicus
Li, M.; Wang, J.; Song, S.; Li, C.
Molecular characterization of a novel nitric oxide synthase gene from Portunus trituberculatus and the roles of NO/O2(-)- generating and antioxidant systems in host immune responses to Hematodinium
Fish Shellfish Immunol.
52
263-277
2016
Portunus trituberculatus (A0A145P6C8), Portunus trituberculatus
Al-Harbi, N.O.; Nadeem, A.; Ansari, M.A.; Al-Harbi, M.M.; Alotaibi, M.R.; AlSaad, A.M.; Ahmad, S.F.
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase
Int. Immunopharmacol.
46
1-8
2017
Mus musculus (P29477), Mus musculus
Sobolewska-Stawiarz, A.; Leferink, N.G.; Fisher, K.; Heyes, D.J.; Hay, S.; Rigby, S.E.; Scrutton, N.S.
Energy landscapes and catalysis in nitric-oxide synthase
J. Biol. Chem.
289
11725-11738
2014
Rattus norvegicus (P29476)
Yokom, A.L.; Morishima, Y.; Lau, M.; Su, M.; Glukhova, A.; Osawa, Y.; Southworth, D.R.
Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain
J. Biol. Chem.
289
16855-16865
2014
Rattus norvegicus (P29476)
Holden, J.K.; Lim, N.; Poulos, T.L.
Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses
J. Biol. Chem.
289
29437-29445
2014
Bacillus subtilis subsp. subtilis (O34453), Bacillus subtilis subsp. subtilis 168 (O34453)
Dai, Y.; Haque, M.M.; Stuehr, D.J.
Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis
J. Biol. Chem.
292
6753-6764
2017
Rattus norvegicus (P29476)
Rouaud, F.; Romero-Perez, M.; Wang, H.; Lobnysheva, I.; Ramassamy, B.; Henry, E.; Tauc, P.; Giacchero, D.; Boucher, J.L.; Deprez, E.; Rocchi, S.; Slama-Schwok, A.
Regulation of NADPH-dependent nitric oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue
Oncotarget
5
10650-10664
2014
Homo sapiens, Mus musculus (P70313)
Chen, Y.; Jiang, B.; Zhuang, Y.; Peng, H.; Chen, W.
Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors
PLoS ONE
12
e0179978
2017
Bos taurus (P29473), Bos taurus
Yan, J.; Shang, F.F.; He, A.; Hu, S.; Luo, S.; Xia, Y.
N-Glycosylation at Asn695 might suppress inducible nitric oxide synthase activity by disturbing electron transfer
Acta Biochim. Biophys. Sin.
52
1360-1372
2020
Mus musculus (P29477), Mus musculus, Mus musculus C57BL/6 (P29477)
Hristov, M.; Landzhov, B.; Yakimova, K.
Increased NADPH-diaphorase reactivity in the hypothalamic paraventricular nucleus and tanycytes following systemic administration of leptin in rats
Acta Histochem.
121
690-694
2019
Rattus norvegicus (P29476), Rattus norvegicus, Rattus norvegicus Wistar (P29476)
Chennoufi, R.; Cabrie, A.; Nguyen, N.H.; Bogliotti, N.; Simon, F.; Cinquin, B.; Tauc, P.; Boucher, J.L.; Slama-Schwok, A.; Xie, J.; Deprez, E.
Light-induced formation of NO in endothelial cells by photoactivatable NADPH analogues targeting nitric-oxide synthase
Biochim. Biophys. Acta
1863
1127-1137
2019
Homo sapiens (P29474)
Di Natale, M.R.; Hunne, B.; Liew, J.J.M.; Fothergill, L.J.; Stebbing, M.J.; Furness, J.B.
Morphologies, dimensions and targets of gastric nitric oxide synthase neurons
Cell Tissue Res.
388
19-32
2022
Rattus norvegicus (P29476), Rattus norvegicus Sprague-Dawley (P29476)
Yan, T.; Kong, Y.; Fan, W.; Kang, J.; Chen, H.; He, H.; Huang, F.
Expression of nitric oxide synthases in rat odontoblasts and the role of nitric oxide in odontoblastic differentiation of rat dental papilla cells
Dev. Growth Differ.
63
354-371
2021
Rattus norvegicus (P29476), Rattus norvegicus Sprague Dawley (P29476)
Freire, M.A.M.; Lima, R.R.; Nascimento, P.C.; Gomes-Leal, W.; Pereira, A.
Effects of methylmercury on the pattern of NADPH diaphorase expression and astrocytic activation in the rat
Ecotoxicol. Environ. Saf.
201
110799
2020
Rattus norvegicus (P29476), Rattus norvegicus Wistar (P29476)
Marquet, N.; Canario, A.; Power, D.
Localization and distribution of nitric oxide synthase and other neuronal markers in the podia of Holothuria arguinensis
Invertebr. Biol.
139
e12298
2020
Holothuria arguinensis
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Guerby, P.; Tasta, O.; Swiader, A.; Pont, F.; Bujold, E.; Parant, O.; Vayssiere, C.; Salvayre, R.; Negre-Salvayre, A.
Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
Redox Biol.
40
101861
2021
Homo sapiens (P29474), Homo sapiens
Seckler, J.M.; Shen, J.; Lewis, T.H.J.; Abdulameer, M.A.; Zaman, K.; Palmer, L.A.; Bates, J.N.; Jenkins, M.W.; Lewis, S.J.
NADPH diaphorase detects S-nitrosylated proteins in aldehyde-treated biological tissues
Sci. Rep.
10
21088
2020
Rattus norvegicus (P29476), Rattus norvegicus Sprague-Dawley (P29476)
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