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Information on EC 1.14.13.243 - toluene 2-monooxygenase

for references in articles please use BRENDA:EC1.14.13.243
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IUBMB Comments
The enzyme, characterized from the bacterium Burkholderia cepacia, belongs to a class of nonheme, oxygen-dependent diiron enzymes. It contains a hydroxylase component with two binuclear iron centers, an NADH-oxidoreductase component containing FAD and a [2Fe-2S] iron-sulfur cluster, and a third component involved in electron transfer between the hydroxylase and the reductase. The enzyme dihydroxylates its substrate in two sequential hydroxylations, initially forming 2-methylphenol, which is hydroxylated to 3-methylcatechol.
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The enzyme appears in viruses and cellular organisms
Synonyms
toluene ortho-monooxygenase, tomA1/2/3/4/5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O
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toluene + NADH + H+ + O2 = 2-methylphenol + NAD+ + H2O
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