Information on EC 1.14.13.237 - aliphatic glucosinolate S-oxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.13.237
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RECOMMENDED NAME
GeneOntology No.
aliphatic glucosinolate S-oxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an omega-(methylthio)alkyl-glucosinolate + NADPH + H+ + O2 = an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glucosinolate biosynthesis from dihomomethionine
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glucosinolate biosynthesis from hexahomomethionine
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glucosinolate biosynthesis from homomethionine
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glucosinolate biosynthesis from pentahomomethionine
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glucosinolate biosynthesis from tetrahomomethionine
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glucosinolate biosynthesis from trihomomethionine
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SYSTEMATIC NAME
IUBMB Comments
omega-(methylthio)alkyl-glucosinolate,NADPH:oxygen S-oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylthiobutyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinylbutyl-glucosinolate + NADP+ + H2O
show the reaction diagram
4-methylthioheptyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinylheptyl-glucosinolate + NADP+ + H2O
show the reaction diagram
4-methylthiohexyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinylhexyl-glucosinolate + NADP+ + H2O
show the reaction diagram
4-methylthiooctyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinyloctyl-glucosinolate + NADP+ + H2O
show the reaction diagram
4-methylthiopentyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinylpentyl-glucosinolate + NADP+ + H2O
show the reaction diagram
4-methylthiopropyl-glucosinolate + NADPH + H+ + O2
4-methylsulfinylpropyl-glucosinolate + NADP+ + H2O
show the reaction diagram
an omega-(methylthio)alkyl-glucosinolate + NADPH + H+ + O2
an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
show the reaction diagram
desulfo-4-methylsulfinylbutyl-glucosinolate + NADPH + H+ + O2
desulfo-4-methylsulfinylbutyl-glucosinolate + NADP+ + H2O
show the reaction diagram
glucoerucin + NADPH + H+ + O2
glucoraphanin + NADP+ + H2O
show the reaction diagram
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additional information
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no activity with methionine, dihomomethionine and 5-methylthiopentaldoxime
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
an omega-(methylthio)alkyl-glucosinolate + NADPH + H+ + O2
an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
show the reaction diagram
glucoerucin + NADPH + H+ + O2
glucoraphanin + NADP+ + H2O
show the reaction diagram
A0A1P7ZDJ6
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.1
calculated from amino acid sequence
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli Top10 cells
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expressed in Escherichia coli Top10 cells; expressed in Escherichia coli Top10 cells; expressed in Escherichia coli Top10 cells; expressed in Escherichia coli Top10 cells; expressed in Escherichia coli Top10 cells
expressed in Nicotiana tabacum leaves and Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is increased under jasmonic acid treatment (0.1 mM)
isoforms FMOGS-OX1, FMOGS-OX2, FMOGS-OX6, and MYB28 show upregulation (5fold) toward absisic acid, isoforms FMOGS-OX5, FMOGS-OX6, and FMOGS-OX7 toward 20 mM 20 mM 1-aminocyclopropane-1-carboxylic acid, isoform FMOGS-OX1 toward 0.05 mM methyl jasmonate, isoform FMOGS-OX7 toward 0.2 mM salicylic acid, and isoforms FMOGS-OX2 and FMOGS-OX5 toward 0.1 mM iodoacetic acid
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