Information on EC 1.14.13.226 - acetone monooxygenase (methyl acetate-forming)

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The expected taxonomic range for this enzyme is: Gordonia sp. TY-5

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EC NUMBER
COMMENTARY hide
1.14.13.226
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RECOMMENDED NAME
GeneOntology No.
acetone monooxygenase (methyl acetate-forming)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetone + NADPH + H+ + O2 = methyl acetate + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
propane degradation I
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Propanoate metabolism
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SYSTEMATIC NAME
IUBMB Comments
acetone,NADPH:oxygen oxidoreductase (methyl acetate-forming)
Contains FAD. The enzyme, characterized from the bacterium Gordonia sp. TY-5, is a Baeyer-Villiger type monooxygenase and participates in a propane utilization pathway.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetone + NADPH + H+ + O2
methyl acetate + NADP+ + H2O
show the reaction diagram
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enzyme catalyzes stoichiometric conversion of acetone to methyl acetate with consumption of NADPH
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?
butan-2-one + NADPH + H+ + O2
methyl propanoate + NADP+ + H2O
show the reaction diagram
82% of the activity with acetone
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?
cyclobutanone + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
131% of the activity with acetone
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?
cyclohexanone + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
135% of the activity with acetone
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?
cyclopentanone + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
170% of the activity with acetone
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?
decan-2-one + NADPH + H+ + O2
methyl nonanoate + NADP+ + H2O
show the reaction diagram
173% of the activity with acetone
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?
heptan-2-one + NADPH + H+ + O2
methyl hexanoate + NADP+ + H2O
show the reaction diagram
80.7% of the activity with acetone
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?
nonan-2-one + NADPH + H+ + O2
methyl octanoate + NADP+ + H2O
show the reaction diagram
186% of the activity with acetone
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?
octan-2-one + NADPH + H+ + O2
methyl heptanoate + NADP+ + H2O
show the reaction diagram
128% of the activity with acetone
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?
pentan-2-one + NADPH + H+ + O2
methyl butanoate + NADP+ + H2O
show the reaction diagram
45% of the activity with acetone
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?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetone + NADPH + H+ + O2
methyl acetate + NADP+ + H2O
show the reaction diagram
A1IHE6
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enzyme catalyzes stoichiometric conversion of acetone to methyl acetate with consumption of NADPH
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
no cofactor: NADH
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
63000
4 * 63000, SDS-PAGE
230000
gel filtration
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 63000, SDS-PAGE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.226)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)