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Enzyme Nomenclature
Information on EC 1.14.13.202 - methyl farnesoate epoxidase
for references in articles please use BRENDA:EC1.14.13.202
Word Map on EC 1.14.13.202
- 1.14.13.202
- juvenile
-
corpora
- allata
-
worker
-
epoxidation
-
larval
- cockroach
-
honey
-
queen
-
caste
-
o-methyltransferase
-
instar
-
vitellogenin
-
hemolymph
-
metamorphosis
- mellifera
-
eusocial
-
blattella
- germanica
-
rnai-mediated
- jhamt
-
pupae
-
allatostatins
-
synthase-2
-
diapause
- punctata
- locust
-
diploptera
-
3-hydroxy-3-methylglutaryl
- agriculture
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.14.13.202
transferred to EC 1.14.14.127
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RECOMMENDED NAME
GeneOntology No.
methyl farnesoate epoxidase
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
collected from colonies kept in the Meliponary of the University of Uberlandia, MG Brazil
A0A286LD89
UniProt
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
-
the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level
malfunction
D6CJJ9;
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
malfunction
interference of gene EcMFE significantly inhibits the biosynthesis of cantharidin in male Epicauta chinensis after mating
metabolism
-
the enzyme catalyzes the final step of juvenile hormone III biosynthesis
metabolism
D6CJJ9;
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
metabolism
A0A286LD89;
the enzyme catalyzes the final step in juvenile hormone, JH, biosynthesis
metabolism
juvenile hormone is finally synthesized via methylation and epoxidation regulated by JH acid O-methyltransferase (JHAMT) and methyl farnesoate epoxidase (MFE), respectively. Genes EcMFE and EcJHEH may be involved in the biosynthesis of cantharidin, but juvenile hormone III (JH III) might not be the direct precursor of cantharidin. Cantharidin is a monoterpene that is proposed to be constituted of two isoprene units. Cantharidin is biosynthesized via the mevalonate pathway that can also synthesize JH III
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
D6CJJ9;
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
-
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
A0A286LD89;
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
D6CJJ9
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
-
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
A0A2C9DK12
-
-
-
?
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
juvenile hormone III + NADP+ + H2O
A0A286LD89
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
cytochrome P450
cytochrome P450 conserved site is located at amino acids 432-441
-
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
expression level of EcMFE is significantly high in the head of males
-
of workers and reproducing queens, high MFE expression in ovaries of bumblebee females
additional information
A0A286LD89;
gene mfe is exclusively expressed in the corpora allata
additional information
-
expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview
additional information
temporal and spatial expression patterns of gene EcMFE, relative expression profiles of EcMFE in tissues and developmental stages, overview. The expression level of EcMFE is high in the first instar larval stage. Transcripts of EcMFE, EcJHEH and EcJHAMT show a similar tendency with the cantharidin production in male blister beetles after mating
additional information
A0A286LD89;
gene mfe expression and juvenile hormone, JH, titers in the life cycle of the highly eusocial stingless bee, hemolymph JH titers for all life cycle stages of Melipona scutellaris queens and workers, overview. The JH titer is high in the second larval instar, drops in the third, and rises again as the larvae enter metamorphosis. During the pupal stage, mfe expression is initialy elevated, but then gradually drops to low levels before adult emergence. No variation is seen in the JH titer. In adult virgin queens, mfe expression and the JH titer are significantly elevated, possibly associated with their reproductive potential. For workers, JH titers are lower in foragers than in nurse bees, while mfe expression does not differ
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
the enzyme has a membrane anchor region at amino acids 2-19, the transmembrane region is located at amino acids 141-158
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene EcMFE, DNA and amino acid sequence determination and analysis, phylogenetic analysis, quantitative RT-PCR enzyme expression analysis
gene mfe, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree, quantitative RT-PCR enzyme expression analysis
A0A286LD89;
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
EcMFE RNAi-mediated knockdown. In EcMFE dsRNA treatment, there are no significant differences between the treated group and controls until the 5th day after injection, when compared on cantharidin content, the cantharidin content is significantly reduced on the 7th day after injection
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.202)
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