Information on EC 1.14.13.176 - tryprostatin B 6-hydroxylase

for references in articles please use BRENDA:EC1.14.13.176
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The expected taxonomic range for this enzyme is: Aspergillus fumigatus

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EC NUMBER
COMMENTARY hide
1.14.13.176
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RECOMMENDED NAME
GeneOntology No.
tryprostatin B 6-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tryprostatin B + NADPH + H+ + O2 = 6-hydroxytryprostatin B + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
fumitremorgin C biosynthesis
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fumitremorgin biosynthesis
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Staurosporine biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
tryprostatin B,NADPH:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
A heme-thiolate protein (P-450). Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
tryprostatin B + NADPH + H+ + O2
6-hydroxytryprostatin B + NADP+ + H2O
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
tryprostatin B + NADPH + H+ + O2
6-hydroxytryprostatin B + NADP+ + H2O
show the reaction diagram
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain YPH500
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.176)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)