We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.14.12.16 - 2-Hydroxyquinoline 5,6-dioxygenase for references in articles please use BRENDA:EC1.14.12.16
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments 3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers
The expected taxonomic range for this enzyme is: Comamonas testosteroni
Synonyms
2-Hydroxyquinoline 5,6-dioxygenase, 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase, Oxygenase, 2(1H)-quinolinone 5,6-di-, Quinolin-2(1H)-one 5,6-dioxygenase, Quinolin-2-ol 5,6-dioxygenase,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-Hydroxyquinoline 5,6-dioxygenase
-
-
-
-
2-oxo-1,2-dihydroquinoline 5,6-dioxygenase
-
-
-
-
Oxygenase, 2(1H)-quinolinone 5,6-di-
-
-
-
-
Quinolin-2(1H)-one 5,6-dioxygenase
-
-
-
-
Quinolin-2-ol 5,6-dioxygenase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)
3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
172399-50-7
not distinguished from EC 1.14.13.65
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-Oxo-1,2-dihydroquinoline + NADH + O2
?
3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
?
8-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
?
-
-
-
-
-
8-Hydroxyquinoline + NADH + O2
?
additional information
?
-
2-Oxo-1,2-dihydroquinoline + NADH + O2
?
-
-
-
-
-
2-Oxo-1,2-dihydroquinoline + NADH + O2
?
-
-
-
-
-
3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
-
NADH cannot be replaced by NADPH
-
-
3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
-
NADH cannot be replaced by NADPH
-
-
6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
?
-
-
-
-
-
6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
?
-
-
-
-
-
8-Hydroxyquinoline + NADH + O2
?
-
-
-
-
-
8-Hydroxyquinoline + NADH + O2
?
-
-
-
-
-
additional information
?
-
-
second enzyme in the pathway of quinoline and 3-methylquinoline degradation
-
-
-
additional information
?
-
-
second enzyme in the pathway of quinoline and 3-methylquinoline degradation
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
-
additional information
?
-
-
second enzyme in the pathway of quinoline and 3-methylquinoline degradation
-
-
-
additional information
?
-
-
second enzyme in the pathway of quinoline and 3-methylquinoline degradation
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NADH
-
required, cannot be replaced by NADPH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Fe2+
-
enhances activity 1.5fold
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,10-phenanthroline
-
0.5 mM, 82% loss of activity
4-hydroxymercuribenzoate
-
0.1 mM, complete loss of activity
Acriflavin
-
0.5 mM, 69% loss of activity
diethyldithiocarbaminate
-
inhibits after a prolonged incubation time
-
EDTA
-
inhibits after a prolonged incubation time
iodoacetate
-
2 mM, complete loss of activity
NaCl
-
0.2 M, 50% loss of activity
Quinacrine
-
0.5 mM, 15% loss of activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
30
-
5 min, 30% loss of activity
65
-
5 min, complete loss of activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dithioerythritol, dithiothreitol and 2-oxo-1,2-dihydroquinoline stabilize
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ethanol
-
5%, decreases enzyme activity to 44%
Ethanol
-
5%, decreases enzyme activity to 44%
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Schach, S.; Tshisuaka, B.; Fetzner, S.; Lingens, F.
Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation
Eur. J. Biochem.
232
536-544
1995
Comamonas testosteroni 63, Comamonas testosteroni
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
1.14.12.16 2-Hydroxyquinoline 5,6-dioxygenase
more
top
Information
