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Information on EC 1.14.12.16 - 2-Hydroxyquinoline 5,6-dioxygenase for references in articles please use BRENDA:EC1.14.12.16
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EC Tree
IUBMB Comments 3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers
The expected taxonomic range for this enzyme is: Comamonas testosteroni
Synonyms
2-oxo-1,2-dihydroquinoline 5,6-dioxygenase,
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2-Hydroxyquinoline 5,6-dioxygenase
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2-oxo-1,2-dihydroquinoline 5,6-dioxygenase
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Oxygenase, 2(1H)-quinolinone 5,6-di-
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Quinolin-2(1H)-one 5,6-dioxygenase
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Quinolin-2-ol 5,6-dioxygenase
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quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+
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quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)
3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers
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172399-50-7
not distinguished from EC 1.14.13.65
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2-Oxo-1,2-dihydroquinoline + NADH + O2
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3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
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8-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
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8-Hydroxyquinoline + NADH + O2
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additional information
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2-Oxo-1,2-dihydroquinoline + NADH + O2
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2-Oxo-1,2-dihydroquinoline + NADH + O2
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3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
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NADH cannot be replaced by NADPH
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3-Methyl-2-oxo-1,2-dihydroquinoline + NADH + O2
5,6-Dihydro-5,6-dihydroxy-(3-methyl-)2-oxo-1,2-dihydroquinoline + NAD+
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NADH cannot be replaced by NADPH
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6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
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6-Hydroxy-2-oxo-1,2-dihydroquinoline + NADH + O2
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8-Hydroxyquinoline + NADH + O2
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8-Hydroxyquinoline + NADH + O2
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second enzyme in the pathway of quinoline and 3-methylquinoline degradation
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second enzyme in the pathway of quinoline and 3-methylquinoline degradation
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additional information
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additional information
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second enzyme in the pathway of quinoline and 3-methylquinoline degradation
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additional information
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second enzyme in the pathway of quinoline and 3-methylquinoline degradation
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NADH
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required, cannot be replaced by NADPH
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Fe2+
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enhances activity 1.5fold
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1,10-phenanthroline
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0.5 mM, 82% loss of activity
4-hydroxymercuribenzoate
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0.1 mM, complete loss of activity
Acriflavin
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0.5 mM, 69% loss of activity
diethyldithiocarbaminate
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inhibits after a prolonged incubation time
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EDTA
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inhibits after a prolonged incubation time
iodoacetate
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2 mM, complete loss of activity
NaCl
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0.2 M, 50% loss of activity
Quinacrine
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0.5 mM, 15% loss of activity
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brenda
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brenda
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30
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5 min, 30% loss of activity
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5 min, complete loss of activity
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dithioerythritol, dithiothreitol and 2-oxo-1,2-dihydroquinoline stabilize
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Ethanol
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5%, decreases enzyme activity to 44%
Ethanol
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5%, decreases enzyme activity to 44%
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Schach, S.; Tshisuaka, B.; Fetzner, S.; Lingens, F.
Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation
Eur. J. Biochem.
232
536-544
1995
Comamonas testosteroni 63, Comamonas testosteroni
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1.14.12.16 2-Hydroxyquinoline 5,6-dioxygenase
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