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Information on EC 1.14.11.B19 - [histone H3]-trimethyl-L-lysine56 demethylase

for references in articles please use BRENDA:EC1.14.11.B19
preliminary BRENDA-supplied EC number
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine56
+
3
+
3
=
a [histone H3]-L-lysine56
+
3
+
3
+
3
Synonyms
JMJD2D, KDM4DL, KDM4E, lysine-specific demethylase 4E, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
(1a)
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine56 + 3 succinate + 3 formaldehyde + 3 CO2
show the reaction diagram
overall reaction
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a [histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
(1b)
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