Information on EC - alkyl sulfatase

for references in articles please use BRENDA:EC1.14.11.77
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EC Tree
IUBMB Comments
Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates. The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate. The enzymes often desulfate a broad spectrum of linear and branched-chain sulfate esters. The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C(4) to C(12). cf. sulfatase EC, arylsulfatase (type I), EC, linear primary-alkylsulfatase, and EC, branched primary-alkylsulfatase.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
2-oxoglutarate-dependent sulfate ester dioxygenase, alpha-ketoglutarate-dependent sulfate ester dioxygenase, AtsK, Rv3406, type II alkyl sulfatase, more
a primary alkyl sulfate ester + 2-oxoglutarate + O2 = an aldehyde + succinate + CO2 + sulfate
show the reaction diagram
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