Reference on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, T.; Buratowski, S.
Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation
J. Biol. Chem.
282
20827-20835
2007
Saccharomyces cerevisiae
Wallrath, L.; Elgin, S.
Stimulating conversations between HP1a and histone demethylase dKDM4A
Mol. Cell
32
601-602
2008
Drosophila melanogaster
Lin, C.H.; Li, B.; Swanson, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Abmayr, S.M.; Workman, J.L.
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
Mol. Cell
32
696-706
2008
Drosophila melanogaster (Q9V333), Drosophila melanogaster
Chang, Y.; Wu, J.; Tong, X.J.; Zhou, J.Q.; Ding, J.
Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem. J.
433
295-302
2010
Saccharomyces cerevisiae (P39956)
Crona, F.; Dahlberg, O.; Lundberg, L.E.; Larsson, J.; Mannervik, M.
Gene regulation by the lysine demethylase KDM4A in Drosophila
Dev. Biol.
373
453-463
2013
Drosophila melanogaster
Liang, C.Y.; Hsu, P.H.; Chou, D.F.; Pan, C.Y.; Wang, L.C.; Huang, W.C.; Tsai, M.D.; Lo, W.S.
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1
Nucleic Acids Res.
39
4151-4165
2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Lin, C.H.; Paulson, A.; Abmayr, S.M.; Workman, J.L.
HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels
PLoS ONE
7
e39758
2012
Drosophila melanogaster
Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A.
The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
ACS Chem. Biol.
12
1011-1019
2017
Homo sapiens (O75164)
Ryu, H.; Ahn, S.
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
BMC Biol.
12
75
2014
Saccharomyces cerevisiae (P39956)
Morera, L.; Roatsch, M.; Fuerst, M.C.; Hoffmann, I.; Senger, J.; Hau, M.; Franz, H.; Schuele, R.; Heinrich, M.R.; Jung, M.
4-biphenylalanine- and 3-phenyltyrosine-derived hydroxamic acids as inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A
ChemMedChem
11
2063-2083
2016
Homo sapiens (O75164)
Pedersen, M.T.; Kooistra, S.M.; Radzisheuskaya, A.; Laugesen, A.; Johansen, J.V.; Hayward, D.G.; Nilsson, J.; Agger, K.; Helin, K.
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
EMBO J.
35
1550-1564
2016
Mus musculus (Q8BW72), Mus musculus (Q8VCD7), Mus musculus (Q91VY5), Mus musculus C57BL/6 (Q8BW72), Mus musculus C57BL/6 (Q8VCD7), Mus musculus C57BL/6 (Q91VY5)
Gacek-Matthews, A.; Noble, L.M.; Gruber, C.; Berger, H.; Sulyok, M.; Marcos, A.T.; Strauss, J.; Andrianopoulos, A.
KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans
Mol. Microbiol.
96
839-860
2015
Aspergillus nidulans (Q5BEH0), Aspergillus nidulans ATCC 38163 (Q5BEH0), Aspergillus nidulans CBS 112.46 (Q5BEH0), Aspergillus nidulans FGSC A4 (Q5BEH0), Aspergillus nidulans M139 (Q5BEH0), Aspergillus nidulans NRRL 194 (Q5BEH0)
Kupershmit, I.; Khoury-Haddad, H.; Awwad, S.W.; Guttmann-Raviv, N.; Ayoub, N.
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Nucleic Acids Res.
42
6168-6182
2014
Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q9H3R0)
An, J.; Xu, J.; Li, J.; Jia, S.; Li, X.; Lu, Y.; Yang, Y.; Lin, Z.; Xin, X.; Wu, M.; Zheng, Q.; Pu, H.; Gui, X.; Li, T.; Lu, D.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372
Oncotarget
8
49093-49109
2017
Homo sapiens (O75164)
Li, W.; Zhao, L.; Zang, W.; Liu, Z.; Chen, L.; Liu, T.; Xu, D.; Jia, J.
Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
Biochem. Biophys. Res. Commun.
416
372-378
2011
Homo sapiens (O94953)
-
Marmorstein, R.; Trievel, R.C.
Histone modifying enzymes structures, mechanisms, and specificities
Biochim. Biophys. Acta
1789
58-68
2009
Homo sapiens (O75164)
Li, Q.; Ke, Q.; Costa, M.
Alterations of histone modifications by cobalt compounds
Carcinogenesis
30
1243-1251
2009
Homo sapiens (O75164)
Whetstine, J.R.; Nottke, A.; Lan, F.; Huarte, M.; Smolikov, S.; Chen, Z.; Spooner, E.; Li, E.; Zhang, G.; Colaiacovo, M.; Shi, Y.
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
Cell
125
467-481
2006
Homo sapiens (O75164), Caenorhabditis elegans (Q9U297)
Black, J.C.; Manning, A.L.; Van Rechem, C.; Kim, J.; Ladd, B.; Cho, J.; Pineda, C.M.; Murphy, N.; Daniels, D.L.; Montagna, C.; Lewis, P.W.; Glass, K.; Allis, C.D.; Dyson, N.J.; Getz, G.; Whetstine, J.R.
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors
Cell
154
541-555
2013
Homo sapiens (O75164)
Pfister, S.X.; Ahrabi, S.; Zalmas, L.P.; Sarkar, S.; Aymard, F.; Bachrati, C.Z.; Helleday, T.; Legube, G.; La Thangue, N.B.; Porter, A.C.; Humphrey, T.C.
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
Cell Rep.
7
2006-2018
2014
Homo sapiens (O75164)
Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
Histone demethylase JmjD2A regulates neural crest specification
Dev. Cell
19
460-468
2010
Gallus gallus (E1C6D5)
Lee, K.; Ranger, M.; Meneghini, M.
Combinatorial genetic control of Rpd3S through histone H3K4 and H3K36 methylation in budding yeast
G3 (Bethesda)
8
3411-3420
2018
Saccharomyces cerevisiae (P39956)
Lorbeck, M.T.; Singh, N.; Zervos, A.; Dhatta, M.; Lapchenko, M.; Yang, C.; Elefant, F.
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
Gene
450
8-17
2009
Drosophila melanogaster (Q9V333)
Kim, T.; Buratowski, S.
Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation
J. Biol. Chem.
282
20827-20835
2007
Saccharomyces cerevisiae (P39956)
Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
J. Biol. Chem.
286
41616-41625
2011
Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q9H3R0)
Duan, L.; Perez, R.E.; Lai, X.; Chen, L.; Maki, C.G.
The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells
J. Biol. Chem.
294
9186-9197
2019
Homo sapiens
Liang, C.Y.; Wang, L.C.; Lo, W.S.
Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress in Saccharomyces cerevisiae
Mol. Biol. Cell
24
3251-3262
2013
Saccharomyces cerevisiae (P39956)
Lin, C.H.; Li, B.; Swanson, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Abmayr, S.M.; Workman, J.L.
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
Mol. Cell
32
696-706
2008
Drosophila melanogaster (Q9V333), Drosophila melanogaster
Tan, M.K.; Lim, H.J.; Harper, J.W.
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation
Mol. Cell. Biol.
31
3687-3699
2011
Homo sapiens (O75164)
Couture, J.; Collazo, E.; Ortiz-Tello, P.A.; Brunzelle, J.S.; Trievel, R.C.
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase
Nat. Struct. Mol. Biol.
14
689-695
2007
Homo sapiens (O75164)
Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Nature
442
312-316
2006
Homo sapiens (O75164)
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Nature
448
87-91
2007
Homo sapiens (O75164)
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Characterization of Drosophila melanogaster JmjC+N histone demethylases
Nucleic Acids Res.
36
2852-2863
2008
Drosophila melanogaster (Q9V333), Drosophila melanogaster (Q9V6L0)
Liang, C.; Hsu, P.; Chou, D.; Pan, C.; Wang, L.; Huang, W.; Tsai, M.; Lo, W.
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1
Nucleic Acids Res.
39
4151-4165
2011
Saccharomyces cerevisiae (P39956)
-
Gautam, D.; Johnson, B.A.; Mac, M.; Moody, C.A.
SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle
PLoS Pathog.
14
e1007367
2018
Homo sapiens
Chen, Z.; Zang, J.; Kappler, J.; Hong, X.; Crawford, F.; Wang, Q.; Lan, F.; Jiang, C.; Whetstine, J.; Dai, S.; Hansen, K.; Shi, Y.; Zhang, G.
Structural basis of the recognition of a methylated histone tail by JMJD2A
Proc. Natl. Acad. Sci. USA
104
10818-10823
2007
Homo sapiens (O75164)
Wei, J.; Antony, J.; Meng, F.; MacLean, P.; Rhind, R.; Laible, G.; Oback, B.
KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency
Sci. Rep.
7
7514
2017
Mus musculus (Q91VY5)
Agger, K.; Nishimura, K.; Miyagi, S.; Messling, J.E.; Rasmussen, K.D.; Helin, K.
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
Blood
134
1154-1158
2019
Mus musculus (Q91VY5)
Li, M.; Cheng, J.; Ma, Y.; Guo, H.; Shu, H.; Huang, H.; Kuang, Y.; Yang, T.
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling
Cancer Cell Int.
20
101
2020
Homo sapiens (O75164)
Cui, S.Z.; Lei, Z.Y.; Guan, T.P.; Fan, L.L.; Li, Y.Q.; Geng, X.Y.; Fu, D.X.; Jiang, H.W.; Xu, S.H.
Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy
Cancer Sci.
111
1567-1581
2020
Mus musculus (Q8BW72)
Ding, G.; Xu, X.; Li, D.; Chen, Y.; Wang, W.; Ping, D.; Jia, S.; Cao, L.
Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation
Cell Death Dis.
11
893
2020
Homo sapiens (O75164)
Zhou, J.; Wang, F.; Xu, C.; Zhou, Z.; Zhang, W.
The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice
Exp. Cell Res.
361
155-162
2017
Mus musculus (Q8BW72)
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