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Information on EC 1.14.11.61 - feruloyl-CoA 6-hydroxyla

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IUBMB Comments
Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. cf. EC 1.14.11.62, trans-4-coumaroyl-CoA 2-hydroxylase.
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Word Map
  • 1.14.11.61
  • coumarins
  • dioxygenase
  • scopolin
  • rhizosphere
  • exudate
  • phenylpropanoids
  • phytoalexins
  • 2-oxoglutarate-dependent
  • benthamiana
  • deficiency-induced
  • microbiome
  • attenuata
  • iron-mobilizing
  • ja-deficient
  • jasmonate
  • alternata
The enzyme appears in viruses and cellular organisms
Synonyms
CYP98A22, F6'H1, F6'H2_3, F6H1-2, F6H1-3, feruloyl CoA ortho-hydroxylase 1, feruloyl-CoA 6'-hydroxylase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
show the reaction diagram
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