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Information on EC 1.14.11.51 - DNA N6-methyladenine demethylase

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IUBMB Comments
Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
N6-methyladenine in DNA
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adenine in DNA
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Synonyms
alkbh1, nmad-1, dna 6ma demethylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
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