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Information on EC 1.14.11.45 - L-isoleucine 4-hydroxylase

for references in articles please use BRENDA:EC1.14.11.45

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IUBMB Comments

The enzyme, characterized from the bacterium Bacillus thuringiensis, can also catalyse the hydroxylation of L-leucine, L-norvaline, L-norleucine, and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine.

The enzyme appears in viruses and cellular organisms

Synonyms
l-isoleucine dioxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-isoleucine + 2-oxoglutarate + O2 = (4S)-4-hydroxy-L-isoleucine + succinate + CO2
show the reaction diagram
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