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BRENDA support

Information on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase

for references in articles please use BRENDA:EC1.14.11.4

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IUBMB Comments

Requires Fe2+ and ascorbate.

The enzyme appears in viruses and cellular organisms

Synonyms
jmjd6, plod2, lysyl hydroxylase, plod1, plod3, lysyl hydroxylase 2, lysyl hydroxylase 3, lysyl hydroxylase 1, procollagen-lysine 2-oxoglutarate 5-dioxygenase 2, procollagen-lysine 2-oxoglutarate 5-dioxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[procollagen]-L-lysine + 2-oxoglutarate + O2 = [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
procollagen hydroxylation and glycosylation
Highest Expressing Human Cell Lines
Cell Line Links Gene Links