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Disease on EC 1.14.11.33 - DNA oxidative demethylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
Carcinogenesis
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
DNA repair is indispensable for survival after acute inflammation.
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Carcinoma
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Carcinoma in Situ
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Carcinoma, Non-Small-Cell Lung
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
Colitis
DNA repair is indispensable for survival after acute inflammation.
Colonic Neoplasms
DNA repair is indispensable for survival after acute inflammation.
Colorectal Neoplasms
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
dna oxidative demethylase deficiency
Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming?.
Glioblastoma
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Hodgkin Disease
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome.
Intellectual Disability
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
Leukemia
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
Lung Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.
Neoplasm Metastasis
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Association of AlkB homolog 3 expression with tumor recurrence and unfavorable prognosis in hepatocellular carcinoma.
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
DNA repair is indispensable for survival after acute inflammation.
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Unraveling a connection between DNA demethylation repair and cancer.
Prostatic Hyperplasia
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Prostatic Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Squamous Cell Carcinoma of Head and Neck
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
Urinary Bladder Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.