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Information on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase

for references in articles please use BRENDA:EC1.14.11.29

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IUBMB Comments

Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-α, the α subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
egln1, prolyl hydroxylase domain, hph-1, egln2, hif prolyl, hif-ph, hif-prolyl hydroxylase, p4h-tm, prolyl hydroxylase-2, hif hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
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