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Information on EC 1.14.11.28 - proline 3-hydroxylase

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IUBMB Comments
Requires iron(II) for activity. Unlike the proline hydroxylases involved in collagen biosynthesis [EC 1.14.11.2 (procollagen-proline dioxygenase) and EC 1.14.11.7 (procollagen-proline 3-dioxygenase)], this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme . The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
prolyl 3-hydroxylase 2, c-p3h, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2
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