Reference on EC 1.14.11.21 - clavaminate synthase
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Townsend, C.A.
New reactions in clavulanic acid biosynthesis
Curr. Opin. Chem. Biol.
6
583-589
2002
Streptomyces clavuligerus
Salowe, S.P.; Marsh, E.N.; Townsend, C.A.
Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis
Biochemistry
29
6499-6508
1990
Streptomyces clavuligerus
Salowe, S.P.; Krol, W.J.; Iwata-Reuyl, D.; Townsend, C.A.
Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction
Biochemistry
30
2281-2292
1991
Streptomyces clavuligerus
Elson, S.W.; Baggaley, K.H.; Holland, S.; Nicholson, N.H.; Sime, J.T.; Woroniecki, S.R.
Studies on the substrate specificity of clavaminic acid synthase and associated enzymes
Bioorg. Med. Chem. Lett.
2
1503-1508
1992
Streptomyces clavuligerus
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Iwata-Reuyl, D.; Basak, A.; Silverman, L.S.; Engle, C.A.; Townsend, C.A.
Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase
J. Nat. Prod.
56
1373-1396
1993
Streptomyces clavuligerus
Janc, J.W.; Egan, L.A.; Townsend, C.A.
Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis
J. Biol. Chem.
270
5399-5404
1995
Streptomyces antibioticus, Streptomyces clavuligerus, Streptomyces antibioticus Tu1718
Busby, R.W.; Chang, M.D.T.; Busby, R.C.; Wimp, J.; Townsend, C.A.
Expression and purification of two isoenzymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification
J. Biol. Chem.
270
4262-4269
1995
Streptomyces clavuligerus
Paradkar, A.S.; Jensen, S.E.
Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
J. Bacteriol.
177
1307-1314
1995
Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585
Busby, R.W.; Townsend, C.A.
A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations
Bioorg. Med. Chem.
4
1059-1064
1996
Streptomyces clavuligerus
Baldwin, J.E.; Adlington, R.M.; Bryans, J.S.; Lloyd, M.D.; Sewell, T.J.; Schofield, C.J.; Baggaley, K.H.; Cassels, R.
Chemo-enzymic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
Tetrahedron
53
7011-7020
1997
Streptomyces clavuligerus
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Zhou, J.; Gunsior, M.; Bachmann, B.O.; Townsend, C.A.; Solomon, E.I.
Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: coupling mechanism of oxidative decarboxylation and hydroxylation
J. Am. Chem. Soc.
120
13539-13540
1998
Streptomyces clavuligerus
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Lloyd, M.D.; Merritt, K.D.; Lee, V.; Sewell, T.J.; Wha-Son, B.; Baldwin, J.E.; Schofield, C.J.; Elson, S.W.; Baggaley, K.H.; Nicholson, N.H.
Product-substrate engineering by bacteria: studies on clavaminate synthase, a trifunctional dioxygenase
Tetrahedron
55
10201-10220
1999
Streptomyces clavuligerus
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Zhang, Z.; Ren, J.; Stammers, D.K.; Baldwin, J.E.; Harlos, K.; Schofield, C.J.
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase
Nat. Struct. Biol.
7
127-133
2000
Streptomyces clavuligerus (Q05581)
Khaleeli, N.; Busby, R.W.; Townsend, C.A.
Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model
Biochemistry
39
8666-8673
2000
Streptomyces clavuligerus
Doan, L.X.; Hassan, A.; Lipscomb, S.J.; Dhanda, A.; Zhang, Z.; Schofield, C.J.
Mutagenesis studies on the iron binding ligands of clavaminic acid synthase
Biochem. Biophys. Res. Commun.
279
240-244
2000
Streptomyces clavuligerus
Zhou, J.; Kelly, W.L.; Bachmann, B.O.; Gunsior, M.; Townsend, C.A.; Solomon, E.I.
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional a-KG-dependent non-heme iron enzyme: correlation with mchanisms and reactivities
J. Am. Chem. Soc.
123
7388-7398
2001
Streptomyces clavuligerus (Q05581)
Zhang, Z.; Ren, J.s.; Harlos, K.; McKinnon, C.H.; Clifton, I.J.; Schofield, C.J.
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements
FEBS Lett.
517
7-12
2002
Streptomyces clavuligerus (Q05581)
Borowski, T.; de Marothy, S.; Broclawik, E.; Schofield, C.J.; Siegbahn, P.E.
Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies
Biochemistry
46
3682-3691
2007
Streptomyces clavuligerus (Q05581)
Chin, H.; Goh, K.; Teo, K.; Chan, M.; Lee, S.; Ong, L.
Predicting the catalytic sites of Streptomyces clavuligerus deacetylcephalosporin C synthase and clavaminate synthase 2
Afr. J. Microbiol. Res.
5
3357-3366
2011
Streptomyces clavuligerus (Q05581), Streptomyces clavuligerus (Q05582)
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Shrestha, B.; Dhakal, D.; Darsandhari, S.; Pandey, R.; Pokhrel, A.; Jnawali, H.; Sohng, J.
Heterologous production of clavulanic acid intermediates in Streptomyces venezuelae
Biotechnol. Bioprocess Eng.
22
359-365
2017
Streptomyces clavuligerus (Q53939)
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